All Relations between insulin and kcnj11

Publication Sentence Publish Date Extraction Date Species
Ebru Alp, Sibel Doguizi, Fadime Mutlu Icduygu, Egemen Akgun, Mehmet Ali Sekeroglu, Murat Atabey Oze. An analysis of the relationship between ABCC8 and KCNJ11 gene polymorphisms and diabetic retinopathy in Turkish population. Ophthalmic genetics. 2024-02-27. PMID:38411150. katp and related genes (kcnj11 and abcc8) play an important role in insulin secretion by glucose-stimulated pancreatic beta cells and the regulation of insulin secretion. 2024-02-27 2024-03-02 Not clear
Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersle. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of diabetes investigation. 2023-08-21. PMID:37602910. the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (su)-treated kcnj11 permanent neonatal diabetes. 2023-08-21 2023-09-07 human
Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbon. Case report: Better late than never, but sooner is better: switch from CSII to sulfonylureas in two patients with neonatal diabetes due to KCNJ11 variants. Frontiers in endocrinology. vol 14. 2023-05-30. PMID:37251668. after the acute phase, patients with abcc8 or kcnj11 mutations treated with insulin therapy can switch to hypoglycemic sulfonylureas (su). 2023-05-30 2023-08-14 Not clear
Bishal Thapaliya, Bhaskar Ray, Britny Farahdel, Pranav Suresh, Ram Sapkota, Bharath Holla, Jayant Mahadevan, Jiayu Chen, Nilakshi Vaidya, Nora Perrone-Bizzozero, Vivek Benegal, Gunter Schumann, Vince Calhoun, Jingyu Li. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. Research square. 2023-05-03. PMID:37131621. gene set analysis found significant enrichment in regions of chr11p15 and chr3q26, in the function of potassium channels and insulin secretion, particularly kv3, kir-6.2, sur potassium channels encoded by the kcnc1, kcnj11, and abccc8 genes, respectively, in chr11p15. 2023-05-03 2023-08-14 Not clear
Chenxi Qin, Lina-Marcela Diaz-Gallo, Bowen Tang, Yunzhang Wang, Thuy-Dung Nguyen, Arvid Harder, Yi Lu, Leonid Padyukov, Johan Askling, Sara Häg. Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. European journal of epidemiology. 2023-04-13. PMID:37052755. corresponding ors (95%cis) were 0.83 (0.44-1.55) for genetic variation in the targets of insulin and its analogues (gene: insr), and 1.12 (0.83, 1.49) 1.25 (0.78-2.00) for genetic variation in the sulfonylurea targets (gene: abcc8 and kcnj11). 2023-04-13 2023-08-14 Not clear
Bishal Thapaliya, Bhaskar Ray, Britny Farahdel, Pranav Suresh, Ram Sapkota, Bharath Holla, Jayant Mahadevan, Jiayu Chen, Nilakshi Vaidya, Nora Perrone-Bizzozero, Vivek Benegal, Gunter Schumann, Vince D Calhoun, Jingyu Li. Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression. medRxiv : the preprint server for health sciences. 2023-02-17. PMID:36798402. gene set analysis on the common genes mapped from top promising snps of both meta and mega analyses found significant enrichment in regions of chr11p15 and chr3q26, in the function of potassium channels and insulin secretion, in particular kv3, kir-6.2, sur potassium channels encoded by the kcnc1, kcnj11, and abccc8 genes respectively, in chr11p15. 2023-02-17 2023-08-14 Not clear
Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Maryam Tohidi, Mehdi Hedayati, Fereidoun Azizi, Maryam S Daneshpou. Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case-control study and meta-analysis. Scientific reports. vol 12. issue 1. 2022-12-01. PMID:36456687. due to the central role in insulin secretion, the potassium inwardly-rectifying channel subfamily j member 11 (kcnj11) gene is one of the essential genes for type 2 diabetes (t2d) predisposition. 2022-12-01 2023-08-14 Not clear
Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Maryam Tohidi, Mehdi Hedayati, Fereidoun Azizi, Maryam S Daneshpou. Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case-control study and meta-analysis. Scientific reports. vol 12. issue 1. 2022-12-01. PMID:36456687. we found that the tested variants of kcnj11 have not contributed to t2d incidence in iranian adults, consistent with similar insulin secretion levels among individuals with different genotypes. 2022-12-01 2023-08-14 Not clear
Ji Ho Yun, Min-Gyu Yoo, Ji Young Park, Hye-Ja Lee, Sang Ick Par. Association between KCNJ11 rs5219 variant and alcohol consumption on the effect of insulin secretion in a community-based Korean cohort: a 12-year follow-up study. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:33633334. association between kcnj11 rs5219 variant and alcohol consumption on the effect of insulin secretion in a community-based korean cohort: a 12-year follow-up study. 2021-11-19 2023-08-13 human
Ji Ho Yun, Min-Gyu Yoo, Ji Young Park, Hye-Ja Lee, Sang Ick Par. Association between KCNJ11 rs5219 variant and alcohol consumption on the effect of insulin secretion in a community-based Korean cohort: a 12-year follow-up study. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:33633334. genotype association analyses of the baseline data showed that alcohol consumption is associated with the decreases of blood insulin levels and insulin secretion in participants with the kcnj11 rs5219 risk allele. 2021-11-19 2023-08-13 human
Ji Ho Yun, Min-Gyu Yoo, Ji Young Park, Hye-Ja Lee, Sang Ick Par. Association between KCNJ11 rs5219 variant and alcohol consumption on the effect of insulin secretion in a community-based Korean cohort: a 12-year follow-up study. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:33633334. furthermore, 12-year' follow-up results showed that alcohol consumption synergistically decreases insulin secretion in participants with kcnj11 rs5219 risk alleles. 2021-11-19 2023-08-13 human
Shigeru Suzuki, Tokuo Mukai, Takahide Kokumai, Akiko Furuya, Yusuke Tanahashi, Hiroshi Azum. Sufficient increment of sulfonylurea without reintroduction of insulin ameliorates pubertal deterioration of glycaemic control in KCNJ11 neonatal diabetes treated with long-term sulfonylurea. Diabetologia. vol 63. issue 8. 2021-08-11. PMID:32448915. sufficient increment of sulfonylurea without reintroduction of insulin ameliorates pubertal deterioration of glycaemic control in kcnj11 neonatal diabetes treated with long-term sulfonylurea. 2021-08-11 2023-08-13 Not clear
Vishal Musale, R Charlotte Moffett, Bosede Owolabi, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Mechanisms of action of the antidiabetic peptide [S4K]CPF-AM1 in db/db mice. Journal of molecular endocrinology. vol 66. issue 2. 2021-06-16. PMID:33252358. genes associated with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c, glp1r, gipr) were significantly upregulated by treatment with [s4k]cpf-am1. 2021-06-16 2023-08-13 mouse
Vishal Musale, R Charlotte Moffett, J Michael Conlon, Peter R Flatt, Yasser H Abdel-Waha. Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study. Peptides. vol 136. 2021-06-10. PMID:33338546. peptide administration resulted in a significant (p < 0.01) increase in islet expression of the gene encoding pdx-1, a major transcription factor in islet cells determining β-cell survival and function, resulting in increased expression of genes involved with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c) together with the genes encoding the incretin receptors glp1r and gipr. 2021-06-10 2023-08-13 mouse
Sulaiman Hajji, Khaled Aljenaee, Aoife Garrahy, Maria Byrn. Successful transition from insulin to sulfonylurea, on second attempt, in a 24-year-old female with neonatal diabetes secondary to KCNJ11 gene mutation. BMJ case reports. vol 14. issue 4. 2021-05-14. PMID:33837025. successful transition from insulin to sulfonylurea, on second attempt, in a 24-year-old female with neonatal diabetes secondary to kcnj11 gene mutation. 2021-05-14 2023-08-13 Not clear
Imran Ali Khan, Kiran Kumar Vattam, Parveen Jahan, Kamal Kiran Mukkavali, Qurratulain Hasan, Pragna Ra. Correlation between Genes & diseases. vol 2. issue 3. 2020-10-01. PMID:30258870. the kcnq1 and kcnj11 gene encode potassium channels, which mediate insulin secretion from pancreatic β-cells, and 2020-10-01 2023-08-13 Not clear
Jong Seo Yoon, Kyu Jung Park, Young Bae Sohn, Hae Sang Lee, Jin Soon Hwan. Successful switching from insulin to sulfonylurea in a 3-month-old infant with diabetes due to p.G53D mutation in KCNJ11. Annals of pediatric endocrinology & metabolism. vol 23. issue 3. 2020-10-01. PMID:30286572. successful switching from insulin to sulfonylurea in a 3-month-old infant with diabetes due to p.g53d mutation in kcnj11. 2020-10-01 2023-08-13 Not clear
Jong Seo Yoon, Kyu Jung Park, Young Bae Sohn, Hae Sang Lee, Jin Soon Hwan. Successful switching from insulin to sulfonylurea in a 3-month-old infant with diabetes due to p.G53D mutation in KCNJ11. Annals of pediatric endocrinology & metabolism. vol 23. issue 3. 2020-10-01. PMID:30286572. in this report, we present a case of permanent neonatal diabetes caused by a mutation in the kcnj11 gene that was successfully treated via early switching of insulin to sulfonylurea treatment. 2020-10-01 2023-08-13 Not clear
Ting Chen, Dandan Zhang, Zhenjiang Bai, Shuiyan Wu, Haiying Wu, Rongrong Xie, Ying Li, Fengyun Wang, Xiuli Chen, Hui Sun, Xiaoyan Wang, Linqi Che. Successful Treatment of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Status in an Infant with KCNJ11-Related Neonatal Diabetes Mellitus via Continuous Renal Replacement Therapy. Diabetes therapy : research, treatment and education of diabetes and related disorders. vol 9. issue 5. 2020-09-30. PMID:30094785. the gene analysis revealed a de novo mutation (c.602g > a (p.r201h)) of the kcnj11 gene, and oral glibenclamide successfully replaced insulin treatment in the patient. 2020-09-30 2023-08-13 Not clear
Zhang-Ren Chen, Fa-Zhong He, Mou-Ze Liu, Jin-Lei Hu, Heng Xu, Hong-Hao Zhou, Wei Zhan. MIR4532 gene variant rs60432575 influences the expression of KCNJ11 and the sulfonylureas-stimulated insulin secretion. Endocrine. vol 63. issue 3. 2020-04-27. PMID:30242599. mir4532 gene variant rs60432575 influences the expression of kcnj11 and the sulfonylureas-stimulated insulin secretion. 2020-04-27 2023-08-13 Not clear