| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabel Reinisch, Helene Michenthaler, Alba Sulaj, Elisabeth Moyschewitz, Jelena Krstic, Markus Galhuber, Ruonan Xu, Zina Riahi, Tongtong Wang, Nemanja Vujic, Melina Amor, Riccardo Zenezini Chiozzi, Martin Wabitsch, Dagmar Kolb, Anastasia Georgiadi, Lisa Glawitsch, Ellen Heitzer, Tim J Schulz, Michael Schupp, Wenfei Sun, Hua Dong, Adhideb Ghosh, Anne Hoffmann, Dagmar Kratky, Laura C Hinte, Ferdinand von Meyenn, Albert J R Heck, Matthias Blüher, Stephan Herzig, Christian Wolfrum, Andreas Prokesc. Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape. Nature communications. vol 15. issue 1. 2024-02-15. PMID:38360943. |
adipocyte-specific deletion of p53 prevents lam accumulation during if, increases the catabolic state of adipocytes, and enhances systemic metabolic flexibility and insulin sensitivity. |
2024-02-15 |
2024-02-18 |
mouse |
| Samah A El-Nagdy, Yara M Elfakharany, Manal Mohammad Morsy, Marwa M Ahmad, Samaa Salah Abd El-Fatah, Eman El-Sayed Khaya. The role of fenugreek seed extract in alleviating pancreatic toxic effects and altering glucose homeostasis induced by acetamiprid via modulation of oxidative stress, apoptosis, and autophagy. Tissue & cell. vol 86. 2023-11-10. PMID:37948956. |
acmp-treated cells showed a marked reduction in β- cell immune reactivity to insulin, with pronounced p53, and beclin 1 immune expression. |
2023-11-10 |
2023-11-20 |
rat |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
results have shown differentially expressed p53 target genes involved in apoptosis (bax, fas, pmaip1, and casp8), cell cycle (cyclins, cyclin dependent kinases), glucose metabolism and insulin resistance (thbs1), and p53 regulation (mdm2). |
2023-07-19 |
2023-08-14 |
human |
| M Zanjirband, R Hodayi, Z Safaeinejad, M H Nasr-Esfahani, R Ghaedi-Heydar. Evaluation of the p53 pathway in polycystic ovarian syndrome pathogenesis and apoptosis enhancement in human granulosa cells through transcriptome data analysis. Scientific reports. vol 13. issue 1. 2023-07-19. PMID:37468508. |
p53 plays a critical role in the regulation of apoptosis and cell cycle arrest, metabolism and insulin resistance. |
2023-07-19 |
2023-08-14 |
human |
| Raúl Barzalobre-Geronimo, Alejandra Contreras-Ramos, Aaron I Cervantes-Cruz, Miguel Cruz, Fernando Suárez-Sánchez, Jaime Goméz-Zamudio, Guadalupe Diaz-Rosas, Alejandro Ávalos-Rodríguez, Margarita Díaz-Flores, Clara Ortega-Camarill. Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages. Cell biochemistry and biophysics. 2023-07-01. PMID:37392315. |
bax, p53, and insulin were assessed by western blotting, immunofluorescence, and real-time quantitative pcr. |
2023-07-01 |
2023-08-14 |
rat |
| Lexin Shu, Yuming Wang, Wei Huang, Simiao Fan, Junhua Pan, Qingbo Lv, Lin Wang, Yujing Wang, Jinpeng Xu, Haifeng Yan, Yuchao Bai, Yi Wang, Yubo L. Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Tongmai Yangxin Pills in Ameliorating Doxorubicin-Induced Cardiotoxicity. ACS omega. vol 8. issue 20. 2023-05-30. PMID:37251132. |
based on the combined analysis of 71 targets and different metabolites, tmyxps probably played a role in myocardial protection through regulating upstream proteins of the insulin signaling pathway, mapk signaling pathway, and p53 signaling pathway, as well as the regulation of metabolites related to energy metabolism. |
2023-05-30 |
2023-08-14 |
Not clear |
| Ying Deng, Shuai Jiang, Xueguang Lin, Bo Wang, Bo Chen, Jindong Tong, Weijun Shi, Bo Yu, Jingdong Tan. Differential expression profile of miRNAs between stable and vulnerable plaques of carotid artery stenosis patients. Genes & genetic systems. 2023-04-30. PMID:37121730. |
this indicated that the target genes of the identified demirnas were mainly enriched in protein phosphorylation, transcription, nitrogen compound metabolism, endocytosis and autophagy, and related to signaling pathways of hippo, mapk, insulin, tgf-β, foxo, ampk and p53. |
2023-04-30 |
2023-08-14 |
Not clear |
| Debabrata Mait. Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics. ChemMedChem. 2022-11-01. PMID:36317359. |
in this minireview, we discussed selected peptidomimetic-based approaches for the modulation of important amyloid proteins (islet amyloid polypeptide, amyloid beta, α-synuclein, mutant p53, and insulin) aggregation. |
2022-11-01 |
2023-08-14 |
Not clear |
| Jiayao Feng, Shuting Qiu, Shipeng Zhou, Yue Tan, Yan Bai, Hua Cao, Jiao Guo, Zhengquan S. mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012464. |
this paper will explore the mechanisms by which mtor regulates lipid metabolism (srebps), insulin resistance (foxo1, lipin1), oxidative stress (pig3, p53, jnk), intestinal microbiota (tlrs), autophagy, inflammation, genetic polymorphisms, and epigenetics in nafld. |
2022-08-26 |
2023-08-14 |
Not clear |
| Paulina Estrella-Ibarra, Andrés Cruz-Hernández, Ana Karen Torres-Arreola, Francisco Campos-Maldonado, Adriana Jheny Rodríguez-Mendez, Olga Patricia García-Obregón, Juan Carlos Solís-Sáinz, María Del Carmen Aburto-Fernández, Ricardo M Lerma-Alvarado, Pablo García-Solí. Low miR-222 expression in human visceral adipose tissue is associated with insulin resistance and PTEN and p53 mRNA levels. Endokrynologia Polska. 2022-08-16. PMID:35971931. |
low mir-222 expression in human visceral adipose tissue is associated with insulin resistance and pten and p53 mrna levels. |
2022-08-16 |
2023-08-14 |
human |
| Paulina Estrella-Ibarra, Andrés Cruz-Hernández, Ana Karen Torres-Arreola, Francisco Campos-Maldonado, Adriana Jheny Rodríguez-Mendez, Olga Patricia García-Obregón, Juan Carlos Solís-Sáinz, María Del Carmen Aburto-Fernández, Ricardo M Lerma-Alvarado, Pablo García-Solí. Low miR-222 expression in human visceral adipose tissue is associated with insulin resistance and PTEN and p53 mRNA levels. Endokrynologia Polska. 2022-08-16. PMID:35971931. |
the aim of this is study was to analyse the expression of mir-193b, mir-378, mir-let7-d, and mir-222 in human visceral adipose tissue (vat), as well as their association with obesity, insulin resistance (ir), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (pten), and tumour protein 53 (p53). |
2022-08-16 |
2023-08-14 |
human |
| Jyun-Yi Li, Wei-Ru Huang, Tsai-Ling Liao, Brent L Nielsen, Hung-Jen Li. Oncolytic Avian Reovirus p17-Modulated Inhibition of mTORC1 by Enhancement of Endogenous mTORC1 Inhibitors Binding to mTORC1 To Disrupt Its Assembly and Accumulation on Lysosomes. Journal of virology. 2022-08-10. PMID:35946936. |
these effects could be reversed in the presence of insulin or depletion of p53. |
2022-08-10 |
2023-08-14 |
Not clear |
| Moritz Oster, Markus Galhuber, Jelena Krstic, Julia S Steinhoff, Georgia Lenihan-Geels, Sascha Wulff, Marie F Kiefer, Konstantin M Petricek, Sylvia J Wowro, Roberto E Flores, Na Yang, Chen Li, Yueming Meng, Isabel Reinisch, Manuela Sommerfeld, Stefan Weger, Hansjörg Habisch, Tobias Madl, Tim J Schulz, Andreas Prokesch, Michael Schup. Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis. The Journal of biological chemistry. 2022-07-22. PMID:35868560. |
we show that this repression is relieved by inactivation of foxo1 by insulin, which likely mediates the upregulation of p53 expression upon refeeding. |
2022-07-22 |
2023-08-14 |
mouse |
| Moritz Oster, Markus Galhuber, Jelena Krstic, Julia S Steinhoff, Georgia Lenihan-Geels, Sascha Wulff, Marie F Kiefer, Konstantin M Petricek, Sylvia J Wowro, Roberto E Flores, Na Yang, Chen Li, Yueming Meng, Isabel Reinisch, Manuela Sommerfeld, Stefan Weger, Hansjörg Habisch, Tobias Madl, Tim J Schulz, Andreas Prokesch, Michael Schup. Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis. The Journal of biological chemistry. 2022-07-22. PMID:35868560. |
strikingly, we find that high fat diet-induced insulin resistance with persistent foxo1 activation not only blunted the regulation of p53 but also the induction of p53 target genes like p21 during fasting, indicating overlapping effects of both foxo1 and p53 on target gene expression in a context-dependent manner. |
2022-07-22 |
2023-08-14 |
mouse |
| Moritz Oster, Markus Galhuber, Jelena Krstic, Julia S Steinhoff, Georgia Lenihan-Geels, Sascha Wulff, Marie F Kiefer, Konstantin M Petricek, Sylvia J Wowro, Roberto E Flores, Na Yang, Chen Li, Yueming Meng, Isabel Reinisch, Manuela Sommerfeld, Stefan Weger, Hansjörg Habisch, Tobias Madl, Tim J Schulz, Andreas Prokesch, Michael Schup. Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis. The Journal of biological chemistry. 2022-07-22. PMID:35868560. |
thus, we conclude that p53 acutely controls glycogen storage in the liver and is linked to insulin signaling via foxo1, which has important implications for our understanding of the hepatic adaptation to nutrient availability. |
2022-07-22 |
2023-08-14 |
mouse |
| Sahdeo Prasad, Rajiv Lal. Zinc-curcumin based complexes in health and diseases: An approach in chemopreventive and therapeutic improvement. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 73. 2022-07-03. PMID:35780653. |
these protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. |
2022-07-03 |
2023-08-14 |
Not clear |
| Hardiyanti Syarif, Rani Sauriasari, Famila Takhwifa, Tiara Anindith. Absence of Association Between Serum Mutant p53 with HbA1c and Insulin in Brain Tumor Patients with Type 2 Diabetes Mellitus. Current diabetes reviews. 2022-05-22. PMID:35598233. |
absence of association between serum mutant p53 with hba1c and insulin in brain tumor patients with type 2 diabetes mellitus. |
2022-05-22 |
2023-08-13 |
human |
| Hardiyanti Syarif, Rani Sauriasari, Famila Takhwifa, Tiara Anindith. Absence of Association Between Serum Mutant p53 with HbA1c and Insulin in Brain Tumor Patients with Type 2 Diabetes Mellitus. Current diabetes reviews. 2022-05-22. PMID:35598233. |
this study aim to determine the prevalence of type 2 diabetes mellitus (t2dm) in primary brain tumor (bt) subjects and to assess the relationship between mutant p53 serum and hba1c and insulin. |
2022-05-22 |
2023-08-13 |
human |
| Farzana Kabir, Mohd Nazmul Hasan Ap. Multi-omics analysis predicts fibronectin 1 as a prognostic biomarker in glioblastoma multiforme. Genomics. 2022-05-05. PMID:35513291. |
alongside, kyoto encyclopedia of genes and genomes (kegg) and reactome pathway analyses described the involvement of the degs with various crucial contributing pathways (pi3k-akt signaling pathway, p53 signaling pathway, insulin secretion, etc.) |
2022-05-05 |
2023-08-13 |
Not clear |
| Yongtao Li, Wenshan Bian, Yang Jiang, Danyang Liu, Lei She. hMSCs Migrate under the Chemotaxis of CXCL-13 and Enhance Islet B Cell Activity through p-AKT Signaling Pathway in High-Glucose Environment. Journal of healthcare engineering. vol 2022. 2022-01-17. PMID:35035844. |
the results of western blot showed that the expression of p53 was significantly decreased in the coculture group, and the glucose stimulated insulin secretion test showed that insulin secretion was significantly increased. |
2022-01-17 |
2023-08-13 |
human |