| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christoph U Correll, Samuele Cortese, Giovanni Croatto, Francesco Monaco, Damir Krinitski, Gonzalo Arrondo, Edoardo G Ostinelli, Caroline Zangani, Michele Fornaro, Andrés Estradé, Paolo Fusar-Poli, Andre F Carvalho, Marco Solm. Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review. World psychiatry : official journal of the World Psychiatric Association (WPA). vol 20. issue 2. 2021-05-27. PMID:34002501. |
based on the meta-analytic evidence, the most convincing efficacy profile emerged for amphetamines, methylphenidate and, to a smaller extent, behavioral therapy in attention-deficit/hyperactivity disorder; aripiprazole, risperidone and several psychosocial interventions in autism; risperidone and behavioral interventions in disruptive behavior disorders; several antipsychotics in schizophrenia spectrum disorders; fluoxetine, the combination of fluoxetine and cognitive behavioral therapy (cbt), and interpersonal therapy in depression; aripiprazole in mania; fluoxetine and group cbt in anxiety disorders; fluoxetine/selective serotonin reuptake inhibitors, cbt, and behavioral therapy with exposure and response prevention in obsessive-compulsive disorder; cbt in post-traumatic stress disorder; imipramine and alarm behavioral intervention in enuresis; behavioral therapy in encopresis; and family therapy in anorexia nervosa. |
2021-05-27 |
2023-08-13 |
Not clear |
| Sara Bertolín, Pino Alonso, Cinto Segalàs, Eva Real, María Alemany-Navarro, Virginia Soria, Susana Jiménez-Murcia, José Manuel Crespo, José M Menchó. First manic/hypomanic episode in obsessive-compulsive disorder patients treated with antidepressants: A systematic review. Journal of psychiatric research. vol 137. 2021-05-20. PMID:33744511. |
high doses of antidepressants, particularly clomipramine and selective serotonin reuptake inhibitors (ssris), are the well-established treatment for obsessive-compulsive disorder (ocd), but manic/hypomanic episodes are potential adverse events associated with this treatment. |
2021-05-20 |
2023-08-13 |
Not clear |
| Michele Protti, Camilla Marasca, Marco Cirrincione, Andrea Cavalli, Roberto Mandrioli, Laura Mercolin. Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites. The Analyst. vol 145. issue 17. 2021-05-14. PMID:32749392. |
the selective serotonin reuptake inhibitors (ssris) fluoxetine and sertraline, chosen as target compounds for this study, are two antidepressants mainly used for major depression, but also for obsessive-compulsive disorder associated with neurodegenerative diseases and for eating disorders. |
2021-05-14 |
2023-08-13 |
Not clear |
| Miriam A Schiele, Christiane Thiel, Magdalena Weidner, Dominique Endres, Michael Zaudig, Götz Berberich, Katharina Domschk. Serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder - Predictor of impaired response to exposure treatment? Journal of psychiatric research. vol 132. 2021-05-14. PMID:33035761. |
serotonin transporter gene promoter hypomethylation in obsessive-compulsive disorder - predictor of impaired response to exposure treatment? |
2021-05-14 |
2023-08-13 |
Not clear |
| Xiaoxiao Zheng, Keith M Kendric. Neural and Molecular Contributions to Pathological Jealousy and a Potential Therapeutic Role for Intranasal Oxytocin. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33959017. |
however, there is increasing interest in a potential role for the neuropeptide oxytocin, which can also modulate dopaminergic and serotonin systems in the brain and has been shown to altered in other psychotic conditions, such as schizophrenia and obsessive compulsive disorder. |
2021-05-08 |
2023-08-13 |
Not clear |
| Lu Lu, Tianran Zhang, Rui Gao, Zongfeng Zhang, Xuan Cao, Yongjun Chen, Ying Liu, Fei Zhang, Yue Zheng, Yan Sun, Yanle Bai, Jianyu Wang, Fabrizio Didonna, Haiyin Zhang, Qing Fa. Mindfulness-based cognitive therapy for obsessive-compulsive disorder: Study protocol for a randomized controlled trial with functional magnetic resonance imaging and a 6-month follow-up. Journal of health psychology. vol 25. issue 13-14. 2021-04-27. PMID:29974808. |
a total of 120 un-medicated chinese obsessive-compulsive disorder patients will be randomized to the mindfulness-based cognitive therapy group, the selective serotonin reuptake inhibitor group or the psycho-education group for 11 sessions in 10 weeks. |
2021-04-27 |
2023-08-13 |
Not clear |
| Jonathon Skurya, Mohammad Jafferany, Gregory J Everet. Habit reversal therapy in the management of body focused repetitive behavior disorders. Dermatologic therapy. vol 33. issue 6. 2021-04-26. PMID:32542916. |
habit reversal therapy has also seen success through augmentation with additional therapies such as mindfulness, or treatment with a selective serotonin reuptake inhibitor in a patient with comorbid obsessive compulsive disorder. |
2021-04-26 |
2023-08-13 |
Not clear |
| Qiang Lu, Chiaki Murakami, Yuki Murakami, Fumi Hoshino, Maho Asami, Takako Usuki, Hiromichi Sakai, Fumio Sakan. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. FEBS letters. vol 594. issue 11. 2021-04-16. PMID:32134507. |
serotonin transporter (sert) is involved in serotonergic system regulation and in the pathophysiology/therapeutics of serotonin-/sert-related diseases such as obsessive-compulsive disorder, depression, autism, and schizophrenia. |
2021-04-16 |
2023-08-13 |
mouse |
| Kally C O'Reilly, Michelle Connor, Jamie Pierson, Lauren C Shuffrey, Randy D Blakely, Susanne E Ahmari, Jeremy Veenstra-VanderWeel. Serotonin 5-HT Psychopharmacology. vol 238. issue 4. 2021-03-30. PMID:33511450. |
furthermore, elevated whole-blood 5-ht has also been described in patients with pediatric obsessive-compulsive disorder. |
2021-03-30 |
2023-08-13 |
Not clear |
| Ronan Depoortere, Laurent Bardin, Agnès L Auclair, Liesbeth A Bruins Slot, Adrian Newman-Tancred. Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists. Pharmacology. vol 106. issue 1-2. 2021-03-22. PMID:32950991. |
obsessive compulsive disorder (ocd) is a psychiatric disorder characterized by excessive and repetitive thoughts and gestures, mainly treated pharmacologically with selective serotonin reuptake inhibitors (ssris). |
2021-03-22 |
2023-08-13 |
mouse |
| Jeffrey A Mills, Jeffrey R Straw. Antidepressant Tolerability in Pediatric Anxiety and Obsessive-Compulsive Disorders: A Bayesian Hierarchical Modeling Meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry. vol 59. issue 11. 2021-03-18. PMID:31682918. |
to compare adverse events (aes), suicidality, and ae-related discontinuation in double-blind, placebo-controlled trials of pediatric patients with obsessive-compulsive disorder (ocd) and anxiety disorders treated with selective serotonin reuptake inhibitors (ssris) or serotonin-norepinephrine reuptake inhibitors (snris). |
2021-03-18 |
2023-08-13 |
Not clear |
| Minah Kim, Wi Hoon Jung, Geumsook Shim, Jun Soo Kwo. The effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive-compulsive disorder. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244182. |
the effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive-compulsive disorder. |
2021-03-15 |
2023-08-13 |
Not clear |
| Minah Kim, Wi Hoon Jung, Geumsook Shim, Jun Soo Kwo. The effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive-compulsive disorder. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244182. |
whether brain network connectivity during goal-directed planning in patients with obsessive-compulsive disorder (ocd) is abnormal and restored by treatment with selective serotonin reuptake inhibitors (ssris) remains unknown. |
2021-03-15 |
2023-08-13 |
Not clear |
| Tulika Shukla, Ravi Kumar Nadella, Reshma Jabeen Taj M J, Suhas Ganesh, Gerald Nestadt, Meera Purushottam, Sanjeev Jain, Y C Janardhan Reddy, Biju Viswanat. Association of SLC1A1 gene polymorphism with obsessive compulsive disorder in a sample from southern India. Experimental and clinical psychopharmacology. vol 28. issue 6. 2021-03-12. PMID:31985241. |
the glutamate transporter gene slc1a1 has been shown to have an association with obsessive-compulsive disorder (ocd), and serotonin reuptake inhibitor (sri) treatment response. |
2021-03-12 |
2023-08-13 |
human |
| Gabriela M Ferreira, Lucy Albertella, Maria Eduarda Moreira-de-Oliveira, Marcelo Piquet-Pessôa, Murat Yücel, Rico S C Lee, Karina B Batista, Gabriela B de Menezes, Leonardo F Fontenell. Fear driven compulsive behaviour is associated with worse long-term outcome in obsessive-compulsive disorder. Human psychopharmacology. vol 35. issue 1. 2021-02-05. PMID:31961460. |
in this retrospective study of patients with obsessive-compulsive disorder (ocd), we assessed the relationship between different motivational drivers of compulsive behaviours and the response to naturalistic treatments (based mostly on high dose serotonin reuptake inhibitors [sris]). |
2021-02-05 |
2023-08-13 |
Not clear |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
effect of escitalopram on serum gdnf and bdnf levels and 5-ht level of brain tissue of obsessive-compulsive disorder rats. |
2021-01-22 |
2023-08-13 |
rat |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
the present study aims to discuss the effect of escitalopram in glial cell line-derived neurotrophic factor (gdnf), brain-derived neurotrophic factor (bdnf) levels, and 5-hydroxytryptamine (5-ht) in obsessive-compulsive disorder rats. |
2021-01-22 |
2023-08-13 |
rat |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
escitalopram could increase gdnf and bdnf levels and 5-ht content in serum and brain tissue in obsessive-compulsive disorder rats, which contributes to a function on the treatment of obsessive-compulsive disorder. |
2021-01-22 |
2023-08-13 |
rat |
| Murat Coskun, Ali Karayagmurl. Aripiprazole Treatment for Obsessive Compulsive Disorder in 2 Young Subjects Who Could Not Tolerate Selective Serotonin Reuptake Inhibitors (SSRIs). Journal of clinical psychopharmacology. vol 40. issue 3. 2021-01-13. PMID:32332471. |
aripiprazole treatment for obsessive compulsive disorder in 2 young subjects who could not tolerate selective serotonin reuptake inhibitors (ssris). |
2021-01-13 |
2023-08-13 |
human |
| Christine Lochner, Samuel R Chamberlain, Martin Kidd, Lian Taljaard, Naomi A Fineberg, Trevor W Robbins, Dan J Stei. The effects of acute serotonin challenge on executive planning in patients with obsessive-compulsive disorder (OCD), their first-degree relatives, and healthy controls. Psychopharmacology. vol 237. issue 10. 2021-01-12. PMID:32638035. |
the effects of acute serotonin challenge on executive planning in patients with obsessive-compulsive disorder (ocd), their first-degree relatives, and healthy controls. |
2021-01-12 |
2023-08-13 |
Not clear |