| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akihiro Hasumi, Hideyuki Maed. Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug. Journal of cannabis research vol 5 issue 1 2023 36871008 |
recent behavioral studies in rats have reported that cbd mediates serotonin (5-ht1a) receptor action to improve motor dysfunction induced by dopamine (d2) receptor blockade. |
2023-03-04 |
2023-03-06 |
rat |
| Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research vol issue 2023 36858318 |
vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. |
2023-03-01 |
2023-03-06 |
rat |
| David B Finlay, Warwick Mackie, Hunter D J Webb, Lucy R Thomsen, Mhairi Nimick, Rhonda J Rosengren, Julie A Marusich, Michelle Glass, Jenny L Wile. The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus, signalling effects, or metabolism. Pharmacology, biochemistry, and behavior vol issue 2023 36805861 |
a characteristic of amb-fubinaca use in new zealand has included the observation that forensic samples (from autopsies) and drugs seized by police have often been found to contain para-fluorophenylpiperazine (pfpp), a relatively little-characterised piperazine analogue that has been suggested to act through 5ht1a serotonin receptors. |
2023-02-22 |
2023-03-06 |
rat |
| Ragini, Sakshi, Ashok Saini, Indra Man. Endocytosis and signaling of 5-HT1A receptor. Progress in molecular biology and translational science vol 196 issue 2023 36813354 |
5-ht binds to its receptor 5-ht1a to initiate gtp exchange at the gi/o protein, which activates the receptor g protein complex. |
2023-02-22 |
2023-03-06 |
Not clear |
| Pattath Narayanan Suresh Kumar, Rohith Suresh, Vikas Meno. An Open-Label Rater-Blinded Randomized Trial of Vilazodone versus Escitalopram in Major Depression. Indian journal of psychological medicine vol 45 issue 1 2023 36778613 |
vilazodone, a novel selective serotonin reuptake inhibitor and 5-ht1a partial agonist, was approved in 2011 for treatment for major depression. |
2023-02-13 |
2023-03-06 |
Not clear |
| Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences vol 24 issue 3 2023 36769290 |
expression patterns of serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a during human fetal lung development. |
2023-02-11 |
2023-03-06 |
human |
| Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences vol 24 issue 3 2023 36769290 |
we analyzed the expression of the serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a at four different stages of fetal lung development from 12 to 40 weeks of gestation, divided into four groups: the pseudoglandular stage (12-16th week of development; |
2023-02-11 |
2023-03-06 |
human |
| Ching-Yi Lin, Kevin Li, Rajaa Thalluri, Yu-Shang Le. Upregulated 5-HT1A receptor regulation of lower urinary tract function in rats following complete spinal cord injury. Journal of neurotrauma vol issue 2023 36762948 |
here, we investigate the expression levels of the serotonin 1a (5-ht1a) receptor in segments both rostral and caudal to the injured site, as well as the effects of blocking 5-ht1a receptor on micturition using pharmacological interventions in spinally-intact rats or t8 complete sci rats. |
2023-02-10 |
2023-03-06 |
rat |
| Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology vol 13 issue 2023 36588734 |
fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. |
2023-01-02 |
2023-01-30 |
Not clear |
| Jo\\xc3\\xa3o P F Kurita, Anderson H F F Le\\xc3\\xa3o, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, D\\xc3\\xa9bora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience vol issue 2022 36548050 |
the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. |
2022-12-22 |
2023-01-30 |
rat |
| Martin Kubitschke, Monika M\\xc3\\xbcller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Gro\\xc3\\x9f, Pascal Gnei\\xc3\\x9fe, Niklas Meyer, J Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Massec. Next generation genetically encoded fluorescent sensors for serotonin. Nature communications vol 13 issue 1 2022 36473867 |
we developed a family of genetically encoded serotonin (5-ht) sensors (sdarken) on the basis of the native 5-ht1a receptor and circularly permuted gfp. |
2022-12-06 |
2023-01-30 |
Not clear |
| Carla V Arga\\xc3\\xb1araz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England) vol issue 2022 36458556 |
this refinement of drn inputs is not accompanied by changes in 5-ht1a receptor-mediated inhibition over 5-ht neurons. |
2022-12-02 |
2023-01-30 |
mouse |
| Jeanette Tour, Angelica Sandstr\\xc3\\xb6m, Diana Kadetoff, Martin Schalling, Eva Kose. The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls. PloS one vol 17 issue 11 2022 36342939 |
all subjects were genotyped for relevant functional polymorphisms in the genes coding for the \xce\xbc-opioid receptor (oprm1, rs1799971), the serotonin transporter (5-htt, 5-httlpr/rs25531) and the serotonin 1a receptor (5-ht1a, rs6295). |
2022-11-07 |
2023-01-30 |
human |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.) vol issue 2022 36333646 |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-\xce\xb2, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-01-30 |
mouse |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimar\\xc3\\xa3es, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology vol issue 2022 36334768 |
in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. |
2022-11-05 |
2023-01-30 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research vol issue 2022 36272053 |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-01-30 |
Not clear |
| Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E Bartlet. Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice. Molecular psychiatry vol issue 2022 36195637 |
we have previously shown using the "drinking-in-the-dark" model in mice that the stimulation of the serotonin receptor 1a (5-ht |
2022-10-04 |
2023-01-30 |
mouse |
| Bernardo Lopez-Torres, Irma Ares, Marta Mart\\xc3\\xadnez, Jorge-Enrique Maximiliano, Mar\\xc3\\xada-Rosa Mart\\xc3\\xadnez-Larra\\xc3\\xb1aga, Arturo Anad\\xc3\\xb3n, Mar\\xc3\\xada-Ar\\xc3\\xa1nzazu Mart\\xc3\\xadne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol issue 2022 36126889 |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-01-30 |
rat |
| Doo Ri Park, Chang Hwan Yeo, Jee Eun Yoon, Eun Young Hong, Bo Ram Choi, Yoon Jae Lee, In-Hyuk H. Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 153 issue 2022 36076523 |
ps restored vaginal epithelium thickness, by increasing the expression of estrogen receptors er\xce\xb1 (esr1) and er\xce\xb2 (esr2), and increased serotonin concentration by reducing serotonin receptor 1\xc2\xa0a (5-ht1a) and glucocorticoid receptor (gr) expression. |
2022-09-09 |
2023-01-30 |
mouse |
| Andr\\xc3\\xa9a V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Concei\\xc3\\xa7\\xc3\\xa3o, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease vol issue 2022 35951206 |
when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. |
2022-08-11 |
2023-01-30 |
mouse |