All Relations between serotonin and 5-ht receptor 1a

Publication Sentence Publish Date Extraction Date Species
Martin Kubitschke, Monika Müller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Groß, Pascal Gneiße, Niklas Meyer, J Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Massec. Next generation genetically encoded fluorescent sensors for serotonin. Nature communications. vol 13. issue 1. 2022-12-06. PMID:36473867. we developed a family of genetically encoded serotonin (5-ht) sensors (sdarken) on the basis of the native 5-ht1a receptor and circularly permuted gfp. 2022-12-06 2023-08-14 Not clear
Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. this refinement of drn inputs is not accompanied by changes in 5-ht1a receptor-mediated inhibition over 5-ht neurons. 2022-12-02 2023-08-14 mouse
Jeanette Tour, Angelica Sandström, Diana Kadetoff, Martin Schalling, Eva Kose. The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls. PloS one. vol 17. issue 11. 2022-11-07. PMID:36342939. all subjects were genotyped for relevant functional polymorphisms in the genes coding for the μ-opioid receptor (oprm1, rs1799971), the serotonin transporter (5-htt, 5-httlpr/rs25531) and the serotonin 1a receptor (5-ht1a, rs6295). 2022-11-07 2023-08-14 human
Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. 2022-11-05 2023-08-14 mouse
Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. 2022-11-05 2023-08-14 human
Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. 2022-10-22 2023-08-14 Not clear
Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E Bartlet. Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice. Molecular psychiatry. 2022-10-04. PMID:36195637. we have previously shown using the "drinking-in-the-dark" model in mice that the stimulation of the serotonin receptor 1a (5-ht 2022-10-04 2023-08-14 mouse
Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). 2022-09-20 2023-08-14 rat
Doo Ri Park, Chang Hwan Yeo, Jee Eun Yoon, Eun Young Hong, Bo Ram Choi, Yoon Jae Lee, In-Hyuk H. Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076523. ps restored vaginal epithelium thickness, by increasing the expression of estrogen receptors erα (esr1) and erβ (esr2), and increased serotonin concentration by reducing serotonin receptor 1 a (5-ht1a) and glucocorticoid receptor (gr) expression. 2022-09-09 2023-08-14 mouse
Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. 2022-08-11 2023-08-14 mouse
Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. therefore, our findings suggest that in an ad mouse model, t3 supplementation promotes improvements in depression-like behavior, through the modulation of the serotonergic related genes involved in the transmission mediated by 5ht1a receptors and serotonin reuptake, and attenuated disease progression. 2022-08-11 2023-08-14 mouse
I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. 2022-07-17 2023-08-14 zebrafish
Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR. vol 15. 2022-06-27. PMID:35757086. to determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-ht) in the striatum, expression of serotonin-1a (5-ht1a) auto-receptor in the raphe nuclei and circulating levels of leptin and corticosterone were determined in female wistar rats kept on excessive food restriction schedule. 2022-06-27 2023-08-14 rat
Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR. vol 15. 2022-06-27. PMID:35757086. these changes in 5-ht metabolism and 5-ht1a auto-receptor expression were more profound in dr animals as compare to trf animals. 2022-06-27 2023-08-14 rat
Mohit Chauhan, Rebecca Parry, William V Bob. Vilazodone for Major Depression in Adults: Pharmacological Profile and an Updated Review for Clinical Practice. Neuropsychiatric disease and treatment. vol 18. 2022-06-21. PMID:35726313. hypothesized differences in efficacy and adverse effects between other antidepressants and vilazodone based on its multimodal mechanism of action (combining serotonin reuptake inhibition with serotonin 5-ht1a partial agonist effects) have not been comprehensively demonstrated in clinical studies and its effectiveness as a continuation- or maintenance-phase therapeutic is not yet established. 2022-06-21 2023-08-14 Not clear
Roberto Laureano-Melo, Raoni Conceição Dos-Santos, Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Claudio da Silva Almeida, Luís Carlos Reis, Bruno Guimarães Marinho, Gisele Giannocco, Ahmed Rg, Wellington da Silva Côrte. Neonatal D-fenfluramine Treatment Promotes Long-Term Behavioral Changes in Adult Mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-06-19. PMID:35718760. the programmed animals had a decrease in 5ht1a, serotonin transporter (sert), and brain-derived neurotrophic factor (bdnf) expression in the mesencephalic raphe region. 2022-06-19 2023-08-14 mouse
Filipa Viegas, Tiago Ferreira, Cláudia Campo. Using Cariprazine to Ameliorate Negative Symptoms and Metabolic Side Effects of Clozapine and Paliperidone - Clinical Cases. Neuropsychiatric disease and treatment. vol 18. 2022-06-17. PMID:35712695. it presents distinct pharmacodynamic properties, such as d3/d2 partial agonism, preferential binding to d3 receptors, antagonism at the serotonin 5-ht2a and 5-ht2b receptors, partial agonism at 5-ht1a receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). 2022-06-17 2023-08-14 Not clear
Magdalena Jastrzębska-Więsek, Anna Wesołowska, Marcin Kołaczkowski, Mark A Varney, Adrian Newman-Tancredi, RonanY Depoorter. The selective 5-HT1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat. Behavioural pharmacology. 2022-06-13. PMID:35695543. befiradol/f13640) is a highly selective, potent and efficacious serotonin 5-ht1a agonist. 2022-06-13 2023-08-14 rat
Yusuf Oloruntoyin Ayipo, Waleed A Alananzeh, Sani Najib Yahayaa, Mohd Nizam Mord. Molecular Modelling and Virtual Screening to Identify New Piperazine Derivatives as Potent Human 5-HT1A Antagonists and Reuptake Inhibitors. Combinatorial chemistry & high throughput screening. 2022-05-25. PMID:35611784. serotonin/5-ht antagonist and reuptake inhibitors (saris) ameliorate depression by increasing the terminal 5-ht through the activation of somatodendritic 5-ht1a autoreceptors. 2022-05-25 2023-08-13 human
Anne R de Kort, Elbert A Joosten, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-05-16. PMID:35571143. selective targeting of serotonin 5-ht1a and 5-ht3 receptors attenuates acute and long-term hypersensitivity associated with neonatal procedural pain. 2022-05-16 2023-08-13 human