| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne R de Kort, Elbert A Joosten, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. Selective Targeting of Serotonin 5-HT1a and 5-HT3 Receptors Attenuates Acute and Long-Term Hypersensitivity Associated With Neonatal Procedural Pain. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-05-16. PMID:35571143. |
selective targeting of serotonin 5-ht1a and 5-ht3 receptors attenuates acute and long-term hypersensitivity associated with neonatal procedural pain. |
2022-05-16 |
2023-08-13 |
human |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry. vol 13. 2022-05-16. PMID:35573352. |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology. 2022-04-13. PMID:35416690. |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-08-13 |
Not clear |
| Brandon L Oliver, McKenna Burdette, Alma E Pahua, Cassandra Cavazos, Cheyenne A Morales, Bryan D Alvarez, Dionisio A Amode. Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice. Behavioural brain research. 2022-04-03. PMID:35367298. |
pharmacological activation of the serotonin (5-ht) 1b and 5-ht1a receptors has been shown to induce ocd-like perseverative circling and locomotor stereotypy in rodents. |
2022-04-03 |
2023-08-13 |
mouse |
| Anurag Chaudhary, Kalpana Singh, Nishant Verma, Sachin Kumar, Deepak Kumar, Prince Prashant Sharm. Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions. Mini reviews in medicinal chemistry. 2022-04-01. PMID:35362382. |
structural modifications at the chromene ring, middle aliphatic portion, and terminal aromatic ring yielded more potential 5-ht1a (5-hydroxytryptamine 1a) receptor affinity and antidiabetic activity. |
2022-04-01 |
2023-08-13 |
Not clear |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets. 2022-03-25. PMID:35331126. |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-08-13 |
Not clear |
| Robert W Garvey, Enza Lacivita, Mauro Niso, Beata Duszyńska, Paul E Harris, Marcello Leopold. Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor. ChemMedChem. 2022-03-14. PMID:35286016. |
design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-ht1a receptor. |
2022-03-14 |
2023-08-13 |
human |
| Robert W Garvey, Enza Lacivita, Mauro Niso, Beata Duszyńska, Paul E Harris, Marcello Leopold. Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor. ChemMedChem. 2022-03-14. PMID:35286016. |
among the 5-ht receptor subtype found in pancreatic islets, serotonin receptor 1a (5-ht 1a ) demonstrates a unique ability to inhibit beta-cell insulin secretion. |
2022-03-14 |
2023-08-13 |
human |
| Rafael Barrientos, Alberto Alatorre, Aldo Oviedo-Chávez, Alfonso Delgado, Nielsine Nielsen, Enrique Querejet. Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats. Experimental brain research. 2022-03-02. PMID:35234992. |
local application of different doses of serotonin and 8-oh-dpat (a specific 5-ht1a receptor agonist) causes a similar response to fluoxetine effects. |
2022-03-02 |
2023-08-13 |
rat |
| Dené A Voisin, Alison Wakeford, Jonathon Nye, Jiyoung Mun, Sara R Jones, Jason Locke, Kim L Huhman, Mark E Wilson, H Elliott Albers, Vasiliki Michopoulo. Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques. Pharmacology, biochemistry, and behavior. 2022-02-27. PMID:35219757. |
fluoxetine, a selective serotonin (5ht) reuptake inhibitor whose actions are mediated in part by the 5ht1a receptor (5ht1ar), has sex- and social status-specific effects on socioemotional behavior and aggressive behavior. |
2022-02-27 |
2023-08-13 |
Not clear |
| Colleen Synan, Carrie Bowen, David J Heal, Christelle Froger-Colléaux, Patrick M Beardsley, Nina Dedic, Seth C Hopkins, Una Campbell, Kenneth S Kobla. Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats. Drug and alcohol dependence. vol 231. 2022-01-16. PMID:35033729. |
ulotaront (sep-363856) is a trace amine-associated receptor 1 (taar1) agonist with 5-hydroxytryptamine type 1a (5-ht1a) agonist activity that is currently in phase 3 clinical development for the treatment of schizophrenia. |
2022-01-16 |
2023-08-13 |
rat |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology. 2022-01-11. PMID:35016263. |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-01-11 |
2023-08-13 |
rat |
| De-Wei Yang, Jie Su. [Correlation of lifelong premature ejaculation with 5-HT system gene polymorphism]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 8. 2021-12-16. PMID:34914250. |
the pathogenesis of lpe has not been clarified, but it is believed to be related to the regulation of 5-ht and the 5-ht1a and 5-ht2c receptors from the perspective of the theory of 5-ht system neurotransmitter disorder. |
2021-12-16 |
2023-08-13 |
Not clear |
| De-Wei Yang, Jie Su. [Correlation of lifelong premature ejaculation with 5-HT system gene polymorphism]. Zhonghua nan ke xue = National journal of andrology. vol 27. issue 8. 2021-12-16. PMID:34914250. |
current studies indicate that the 5-ht transporter gene-linked polymorphic region (5-httlpr), 5-ht1a receptor gene polymorphism and 5-ht2c receptor gene polymorphism may be associated with the development of and drug effect on lpe. |
2021-12-16 |
2023-08-13 |
Not clear |
| Christoph U Correll, Kenneth S Koblan, Seth C Hopkins, Yan Li, Heather Dworak, Robert Goldman, Antony Loebe. Safety and effectiveness of ulotaront (SEP-363856) in schizophrenia: results of a 6-month, open-label extension study. NPJ schizophrenia. vol 7. issue 1. 2021-12-10. PMID:34887427. |
ulotaront, a trace amine-associated receptor 1 (taar1) and serotonin 5-ht1a receptors agonist, has demonstrated efficacy in the treatment of patients with an acute exacerbation of schizophrenia in a 4-week, double-blind, placebo-controlled study. |
2021-12-10 |
2023-08-13 |
Not clear |
| Munazzah Tasleem, Abdulwahed Alrehaily, Tahani M Almeleebia, Mohammad Y Alshahrani, Irfan Ahmad, Mohammed Asiri, Nadiyah M Alabdallah, Mohd Saee. Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments. Current issues in molecular biology. vol 43. issue 3. 2021-12-10. PMID:34889886. |
conformational changes and fluctuations occurring during wild type and mutant serotonergic receptor, 5-hydroxytryptamine receptors 1a (5ht1a) and yohimbine were assessed by molecular dynamics md simulation studies. |
2021-12-10 |
2023-08-13 |
Not clear |
| Xinxin Jiang, Peirong Liang, Ke Wang, Jun Jia, Xiaomin Wan. Serotonin 1A receptor agonist modulation of motor deficits and cortical oscillations by NMDA receptor interaction in parkinsonian rats. Neuropharmacology. vol 203. 2021-12-03. PMID:34785162. |
although serotonin 1a (5-ht1a) receptor agonists are widely used as the additive compound to reduce l-dopa-induced dyskinesia in parkinson's disease (pd), few studies focused on the effect and mechanism of 5-ht1a receptor agonist on the motor symptoms of pd. |
2021-12-03 |
2023-08-13 |
rat |
| S K Spoelstra, R Bruggeman, H Knegterin. [An antipsychotic without dopamine receptor blockade?] Tijdschrift voor psychiatrie. vol 63. issue 11. 2021-12-02. PMID:34851520. |
sep-363856 is a trace amine-associated receptor 1 (taar1) agonist and a serotonin 5-ht1a agonist with potential antipsychotic properties. |
2021-12-02 |
2023-08-13 |
Not clear |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-ht1a, gaba, glutamate receptor expression in the rat prefrontal cortex. |
2021-11-29 |
2023-08-13 |
rat |
| Tabinda Salman, Rushda Afroz, Shazia Nawaz, Khalid Mahmood, Darakhshan J Haleem, Shamshad Zarin. Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex. Biochimie. vol 191. 2021-11-29. PMID:34454977. |
to understand neurochemical mechanisms and receptors involved in memory enhancing and impairing effects of mpd, the present study concerns the effects of these doses of mpd on serotonin, 5-ht1a, gaba, and nmda receptor mrna expression in the prefrontal cortex (pfc). |
2021-11-29 |
2023-08-13 |
rat |