| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenping Zeng, Canjun Li, Ruikun Wu, Xingguo Yang, Qingyan Wang, Bingqian Lin, Yanan Wei, Hao Li, Ge Shan, Lili Qu, Chunlei Can. Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta. PLoS biology. vol 22. issue 4. 2024-04-23. PMID:38652732. |
notably, lyso-chr2 activation induces autophagy through the mtor pathway, promotes aβ clearance in an autophagy-dependent manner in cellular models, and alleviates aβ-induced paralysis in the caenorhabditis elegans model of alzheimer's disease. |
2024-04-23 |
2024-04-26 |
caenorhabditis_elegans |
| Zong-Ping Zhang, Xue Bai, Wen-Bo Cui, Xiao-Han Chen, Xu Liu, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei, Dong-Sheng Wan. Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743309. |
diterpenoid caesalmin c delays aβ-induced paralysis symptoms via the daf-16 pathway in alzheimer's disease (ad) is the most prevalent neurodegenerative disease in the world. |
2022-06-24 |
2023-08-14 |
Not clear |
| Michael P Kurnellas, Chris M Adams, Raymond A Sobel, Lawrence Steinman, Jonathan B Rothbar. Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Science translational medicine. vol 5. issue 179. 2013-09-30. PMID:23552370. |
our previous work established that amyloidogenic peptides from the small heat shock protein αb crystallin (hspb5) and from amyloid β fibrils, characteristic of alzheimer's disease, were therapeutic in experimental autoimmune encephalomyelitis (eae), reflecting aspects of the pathology of ms. to understand the molecular basis for the therapeutic effect, we showed a set of amyloidogenic peptides composed of six amino acids, including those from tau, amyloid β a4, major prion protein (prp), hspb5, amylin, serum amyloid p, and insulin b chain, to be anti-inflammatory and capable of reducing serological levels of interleukin-6 and attenuating paralysis in eae. |
2013-09-30 |
2023-08-12 |
Not clear |
| Peichuan Zhang, Meredith Judy, Seung-Jae Lee, Cynthia Kenyo. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell metabolism. vol 17. issue 1. 2013-06-24. PMID:23312285. |
daf-16, and probably mdt-15, could act cell nonautonomously in the endoderm to ameliorate the paralysis caused by expressing alzheimer's aβ protein in muscles. |
2013-06-24 |
2023-08-12 |
caenorhabditis_elegans |
| Ricardo Nitrin. The cure of one of the most frequent types of dementia: a historical parallel. Alzheimer disease and associated disorders. vol 19. issue 3. 2006-01-10. PMID:16118533. |
the hypothesis of the syphilitic origin of general paralysis of the insane instigated heated debates during the 19th century, even surpassing those between proponents of the amyloid cascade versus the tau protein hypotheses for alzheimer disease. |
2006-01-10 |
2023-08-12 |
Not clear |
| J C Morris, M Cole, B Q Banker, D Wrigh. Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Annals of neurology. vol 16. issue 4. 1984-12-19. PMID:6497355. |
complete neuropathological examination of four patients reveals findings typical for pick's disease (asymmetrical focal cerebral atrophy), alzheimer's disease (profuse neuritic plaques), and paralysis agitans (neuronal depigmentation, depletion, and lewy body formation in substantia nigra) in addition to a striking but nonspecific spongiform degeneration of superficial cortical layers. |
1984-12-19 |
2023-08-12 |
Not clear |
| T Arendt, V Bigl, A Arendt, A Tennsted. Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease. Acta neuropathologica. vol 61. issue 2. 1983-12-17. PMID:6637393. |
loss of neurons in the nucleus basalis of meynert in alzheimer's disease, paralysis agitans and korsakoff's disease. |
1983-12-17 |
2023-08-12 |
Not clear |
| T Arendt, V Bigl, A Arendt, A Tennsted. Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's Disease. Acta neuropathologica. vol 61. issue 2. 1983-12-17. PMID:6637393. |
the results demonstrate a loss of neurons in the nucleus basalis of meynert in alzheimer's disease (70%), paralysis agitans (77%), and korsakoff's disease (47%) but no marked reduction of neurons in postencephalitic parkinsonism, huntington's disease, chronic alcoholism without dementia, schizophrenia and infantile brain damage. |
1983-12-17 |
2023-08-12 |
Not clear |