| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alyssa H Zhu, Talia M Nir, Shayan Javid, Julio E Villalon-Reina, Amanda L Rodrigue, Lachlan T Strike, Greig I de Zubicaray, Katie L McMahon, Margaret J Wright, Sarah E Medland, John E Blangero, David C Glahn, Peter Kochunov, Asta K Håberg, Paul M Thompson, Neda Jahansha. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. bioRxiv : the preprint server for biology. 2024-03-11. PMID:38463962. |
we found significant associations between apoe4 and fa in wm regions associated with neurodegenerative disease even in healthy individuals across the lifespan, with regional age-by-genotype interactions. |
2024-03-11 |
2024-03-14 |
human |
| Alejandra Figueroa-Vargas, Begoña Góngora, María Francisca Alonso, Alonso Ortega, Patricio Soto-Fernández, Lucía Z-Rivera, Sebastián Ramírez, Francisca González, Paula Muñoz Venturelli, Pablo Billek. The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial. Trials. vol 25. issue 1. 2024-02-23. PMID:38395980. |
therefore, tacs could potentially boost wm in patients with neurodegenerative diseases. |
2024-02-23 |
2024-02-26 |
Not clear |
| Megha Murthy, Gemma Shireby, Yasuo Miki, Emmanuelle Viré, Tammaryn Lashley, Thomas T Warner, Jonathan Mill, Conceição Bettencour. Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue. Neuropathology and applied neurobiology. 2022-12-21. PMID:36542090. |
despite white matter (wm) changes often being observed in neurodegenerative diseases, no study has investigated epigenetic ageing in white matter. |
2022-12-21 |
2023-08-14 |
Not clear |
| Zhengfeng Lai, Luca Cerny Oliveira, Runlin Guo, Wenda Xu, Zin Hu, Kelsey Mifflin, Charles Decarli, Sen-Ching Cheung, Chen-Nee Chuah, Brittany N Dugge. BrainSec: Automated Brain Tissue Segmentation Pipeline for Scalable Neuropathological Analysis. IEEE access : practical innovations, open solutions. vol 10. 2022-09-26. PMID:36157332. |
as neurodegenerative disease pathological hallmarks have been reported in both grey matter (gm) and white matter (wm) with different density distributions, automating the segmentation process of gm/wm would be extremely advantageous for aiding in neuropathologic deep phenotyping. |
2022-09-26 |
2023-08-14 |
Not clear |
| Tyler D Dexter, Daniel Palmer, Ahmed M Hashad, Lisa M Saksida, Tim J Busse. Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction. Frontiers in neuroscience. vol 16. 2022-06-03. PMID:35655752. |
working memory is a fundamental cognitive process for decision-making and is a hallmark impairment in a variety of neuropsychiatric and neurodegenerative diseases. |
2022-06-03 |
2023-08-14 |
mouse |
| Nicholas A Upright, Mark G Baxte. Effects of nicotinic antagonists on working memory performance in young rhesus monkeys. Neurobiology of learning and memory. vol 184. 2021-10-08. PMID:34425219. |
these findings suggest there are some limitations on using systemic nicotinic antagonists to probe the involvement of nicotinic receptors in aspects of dlpfc-dependent working memory function, necessitating alternative strategies to understand the role of this system in cognitive deficits seen in aging and neurodegenerative disease. |
2021-10-08 |
2023-08-13 |
monkey |
| Qian Wang, Xiaoxia Qu, Weiwei Chen, Huaizhou Wang, Caiyun Huang, Ting Li, Ningli Wang, Junfang Xia. Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 4. 2021-07-16. PMID:32580669. |
primary open-angle glaucoma (poag) has been suggested to be a neurodegenerative disease associated with altered cerebral vascular hemodynamics and widespread disruption of neuronal activity within the visual, working memory, attention and executive networks. |
2021-07-16 |
2023-08-13 |
human |
| Isidro Ferrer, Pol Andrés-Benito, Maria Victoria Zelaya, Maria Elena Erro Aguirre, Margarita Carmona, Karina Ausín, Mercedes Lachén-Montes, Joaquín Fernández-Irigoyen, Enrique Santamaría, José Antonio Del Ri. Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta neuropathologica. vol 139. issue 4. 2021-05-17. PMID:31907603. |
globular glial tauopathy (ggt) is a progressive neurodegenerative disease involving the grey matter and white matter (wm) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, oligomeric 4rtau in neurons and in glial cells forming typical globular astrocyte and oligodendrocyte inclusions (gais and gois, respectively) and coiled bodies. |
2021-05-17 |
2023-08-13 |
mouse |
| Vincent Huynh, Philipp Staempfli, Robin Luetolf, Roger Luechinger, Armin Curt, Spyros Kollias, Michèle Hubli, Lars Michel. Investigation of Cerebral White Matter Changes After Spinal Cord Injury With a Measure of Fiber Density. Frontiers in neurology. vol 12. 2021-03-12. PMID:33692736. |
future dti studies may benefit from utilizing this novel marker to investigate complex large wm tracts in patient cohorts with varying presentations of sci or neurodegenerative diseases. |
2021-03-12 |
2023-08-13 |
Not clear |
| Nassir U Al-Khishman, Qi Qi, Austyn D Roseborough, Alexander Levit, Brian L Allman, Udunna C Anazodo, Matthew S Fox, Shawn N Whitehead, Jonathan D Thiesse. TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. EJNMMI research. vol 10. issue 1. 2020-10-16. PMID:32990808. |
accurate and sensitive imaging biomarkers are required to study the progression of white matter (wm) inflammation in neurodegenerative diseases. |
2020-10-16 |
2023-08-13 |
rat |
| Denise R LaBelle, Bern G Lee, Justin B Mille. Dissociation of Executive and Attentional Elements of the Digit Span Task in a Population of Older Adults: A Latent Class Analysis. Assessment. vol 26. issue 7. 2020-10-15. PMID:28621146. |
the digit span task is commonly used by clinicians to parse attentional and executive components of working memory; however, the interrelatedness of these constructs in the context of advanced age and neurodegenerative disease remains an area of active investigation. |
2020-10-15 |
2023-08-13 |
Not clear |
| Tobias R Baumeister, Jowon L Kim, Maria Zhu, Martin J McKeow. White matter myelin profiles linked to clinical subtypes of Parkinson's disease. Journal of magnetic resonance imaging : JMRI. vol 50. issue 1. 2020-09-22. PMID:30444020. |
white matter (wm) microstructural integrity is important for effective brain functioning and alterations have been shown in many neurodegenerative diseases. |
2020-09-22 |
2023-08-13 |
Not clear |
| Silke M Mueller, María García Arias, Gema Mejuto Vázquez, Johannes Schiebener, Matthias Brand, Elisa Wegman. Decision support in patients with mild Alzheimer's disease. Journal of clinical and experimental neuropsychology. vol 41. issue 5. 2020-07-20. PMID:30835634. |
however, previous studies reported a reduction of this competence in patients with neurodegenerative diseases such as alzheimer's disease, which is explained by impairments of executive functions such as cognitive flexibility or working memory. |
2020-07-20 |
2023-08-13 |
human |
| José Bourbon-Teles, Sonya Bells, Derek K Jones, Elizabeth Coulthard, Anne Rosser, Claudia Metzler-Baddele. Myelin Breakdown in Human Huntington's Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer. Neuroscience. vol 403. 2019-07-08. PMID:28579146. |
huntington's disease (hd) leads to white matter (wm) degeneration that may be due to an early breakdown in axon myelination but in vivo imaging correlates of demyelination remain relatively unexplored in hd compared to other neurodegenerative diseases. |
2019-07-08 |
2023-08-13 |
human |
| Wenwen Bai, Tiaotiao Liu, Mengmeng Dou, Mi Xia, Jun Lu, Xin Tia. Repetitive Transcranial Magnetic Stimulation Reverses Aβ1-42-induced Dysfunction in Gamma Oscillation during Working Memory. Current Alzheimer research. vol 15. issue 6. 2019-05-13. PMID:29318972. |
alzheimer's disease (ad) is a neurodegenerative disease that gradually induces cognitive deficits in the elderly and working memory impairment is typically observed in ad. |
2019-05-13 |
2023-08-13 |
Not clear |
| Sudeshna Das, K P Mishra, Lilly Ganju, S B Sing. Intranasally delivered small interfering RNA-mediated suppression of scavenger receptor Mac-1 attenuates microglial phenotype switching and working memory impairment following hypoxia. Neuropharmacology. vol 137. 2019-02-20. PMID:29738851. |
the novel findings of this study for the very first time, unmasked the role of mac-1 receptor in neurodegenerative disease progression under hypoxic condition and at the same time indicated the potential therapeutic value of this non-invasive sirna delivery approach for treating working memory loss. |
2019-02-20 |
2023-08-13 |
mouse |
| Guangxiang Chen, Baiwan Zhou, Hongyan Zhu, Weihong Kuang, Feng Bi, Hua Ai, Zhongwei Gu, Xiaoqi Huang, Su Lui, Qiyong Gon. White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies. Progress in neuro-psychopharmacology & biological psychiatry. vol 83. 2019-01-03. PMID:29330136. |
this study provides a thorough profile of wm volume loss in als and robust evidence that als is a multisystem neurodegenerative disease that involves a variety of subcortical wm tracts extending beyond motor cortex involvement. |
2019-01-03 |
2023-08-13 |
Not clear |
| Céline Charroud, Emmanuelle Le Bars, Jérémy Deverdun, Jason Steffener, François Molino, Meriem Abdennour, Florence Portet, Alain Bonafe, Yaakov Stern, Karen Ritchie, Tasnime N Akbaraly, Nicolas Menjot de Champfleu. Working memory performance is related to intrinsic resting state functional connectivity changes in community-dwelling elderly cohort. Neurobiology of learning and memory. vol 132. 2018-01-31. PMID:27234057. |
characterization of normal age-related changes in resting state brain networks associated with working memory performance is a major prerequisite for studying neurodegenerative diseases. |
2018-01-31 |
2023-08-13 |
human |
| Sudeshna Das, K P Mishra, Lilly Ganju, S B Sing. Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment. Journal of neuroimmunology. vol 313. 2017-11-29. PMID:29146293. |
over activation of glial cell derived innate immune factors induces neuro-inflammation that results in neurodegenerative disease, like working memory impairment. |
2017-11-29 |
2023-08-13 |
mouse |
| Katharine E Stahon, Chinthasagar Bastian, Shelby Griffith, Grahame J Kidd, Sylvain Brunet, Selva Balta. Age-Related Changes in Axonal and Mitochondrial Ultrastructure and Function in White Matter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 39. 2017-08-22. PMID:27683897. |
despite these age-related modifications, axon function is sustained in aging wm, which suggests that age-dependent changes do not lead to irreversible functional decline under normal conditions, as is observed in neurodegenerative diseases. |
2017-08-22 |
2023-08-13 |
mouse |