All Relations between Paralysis and mtor
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Wenping Zeng, Canjun Li, Ruikun Wu, Xingguo Yang, Qingyan Wang, Bingqian Lin, Yanan Wei, Hao Li, Ge Shan, Lili Qu, Chunlei Can. Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta. PLoS biology. vol 22. issue 4. 2024-04-23. PMID:38652732. | notably, lyso-chr2 activation induces autophagy through the mtor pathway, promotes aβ clearance in an autophagy-dependent manner in cellular models, and alleviates aβ-induced paralysis in the caenorhabditis elegans model of alzheimer's disease. | 2024-04-23 | 2024-04-26 | caenorhabditis_elegans |
| Yan Xiong, Jessica C Page, Naagarajan Narayanan, Chao Wang, Zhihao Jia, Feng Yue, Xine Shi, Wen Jin, Keping Hu, Meng Deng, Riyi Shi, Tizhong Shan, Gongshe Yang, Shihuan Kuan. Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1. EBioMedicine. vol 24. 2018-06-18. PMID:29032027. | importantly, pharmacological or genetic inhibition of mtor ameliorates inflammation and prevents paralysis. | 2018-06-18 | 2023-08-13 | mouse |
| Jihye Lee, Yijiang Shi, Mario Vega, Yonghui Yang, Joseph Gera, Michael E Jung, Alan Lichtenstei. Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction. Bioorganic & medicinal chemistry letters. vol 27. issue 20. 2017-11-03. PMID:28916338. | since mtorc1 paralysis protects mm cells against deptor knockdown, it indicates that the protein-protein interaction between deptor and mtor is key to mm viability vs death. | 2017-11-03 | 2023-08-13 | Not clear |