| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
mouse serum albumin induces neuronal apoptosis and tauopathies. |
2024-04-23 |
2024-04-26 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |
| Etsuko Oshima, Takeshi Ishihara, Osamu Yokota, Hanae Nakashima-Yasuda, Shigeto Nagao, Chikako Ikeda, Jun Naohara, Seishi Terada, Yosuke Uchitom. Accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 6. 2014-06-05. PMID:23574527. |
accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies. |
2014-06-05 |
2023-08-12 |
mouse |
| Daniel Feurstein, Kerstin Stemmer, Julia Kleinteich, Tobias Speicher, Daniel R Dietric. Microcystin congener- and concentration-dependent induction of murine neuron apoptosis and neurite degeneration. Toxicological sciences : an official journal of the Society of Toxicology. vol 124. issue 2. 2012-05-16. PMID:21934130. |
the concentration- and congener-dependent mechanisms observed suggest that low concentrations of mc-lf and mc-lw can induce subtle neurodegenerative effects, reminiscent of alzheimer's disease type human tauopathies, and thus should be taken more seriously with regard to potential human health effects than the apical cytotoxicity (apoptosis or necrosis) demonstrated at high mc concentrations. |
2012-05-16 |
2023-08-12 |
human |
| Aikaterini Rousaki, Yoshinari Miyata, Umesh K Jinwal, Chad A Dickey, Jason E Gestwicki, Erik R P Zuiderwe. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology. vol 411. issue 3. 2011-10-03. PMID:21708173. |
however, they also have the ability to inhibit tumor apoptosis and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by tauopathies, including alzheimer's disease. |
2011-10-03 |
2023-08-12 |
human |
| Yi Wen, Shao-Hua Yang, Ran Liu, Evelyn J Perez, Anne Marie Brun-Zinkernagel, Peter Koulen, James W Simpkin. Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17113760. |
here we show that after transient cerebral ischemia, hyperphosphorylated tau accumulates in neurons of the cerebral cortex in the ischemic area, forms filaments similar to those present in human neurodegenerative tauopathies and colocalizes with markers of apoptosis. |
2007-04-26 |
2023-08-12 |
mouse |
| Yi Wen, Shaohua Yang, Ran Liu, James W Simpkin. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353210. |
the hyperphosphorylated tau presents a conformation similar to those present in human tauopathies, and colocalizes largely with signs of apoptosis. |
2006-03-23 |
2023-08-12 |
human |
| Z Zhao, L Ho, J Suh, W Qin, H Pyo, P Pompl, H Ksiezak-Reding, G M Pasinett. A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis. Molecular and cellular neurosciences. vol 24. issue 2. 2004-01-23. PMID:14572459. |
in exploring the causative role of the most common pro(301)-to-leu (taup301l) tau missense mutation associated with neurodegenerative tauopathies, we examined taup301l-mediated apoptotic cell death and the expression of a cluster of genes involved in the inhibition of apoptosis (iaps) in human neuroblastoma sh-sy5y cells. |
2004-01-23 |
2023-08-12 |
human |
| I Ferrer, M Barrachina, B Pui. Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. Acta neuropathologica. vol 104. issue 6. 2003-02-12. PMID:12410379. |
moreover, the elevated number of tau-containing cells stained with anti-gsk-3beta-p antibodies suggests a partial inactivation of the kinase, or sequestration of the phosphorylated form, which may contribute to the regulation of the cascade of tau hyperphosphorylation in tauopathies, and to protect tau-containing cells from apoptosis. |
2003-02-12 |
2023-08-12 |
Not clear |