| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madia Lozupone, Vittorio Dibello, Antonio Daniele, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panz. How can we manage progressive supranuclear palsy syndrome with pharmacotherapy? Expert opinion on pharmacotherapy. 2024-04-23. PMID:38653731. |
tauopathies are a spectrum of clinicopathological neurodegenerative disorders with increased aggregates included in glia and/or neurons of hyperphosphorylated insoluble tau protein, a microtubule-associated protein. |
2024-04-23 |
2024-04-26 |
Not clear |
| Laura Vidal-Palencia, Cristina Font, Agustín Rebollada-Merino, Gabriel Santpere, Pol Andrés-Benito, Isidro Ferrer, Martí Pumarol. Primary Feline Tauopathy: Clinical, Morphological, Immunohistochemical, and Genetic Studies. Animals : an open access journal from MDPI. vol 13. issue 18. 2023-09-28. PMID:37760385. |
tauopathies are a group of neurodegenerative diseases characterized by the pathological aggregation of hyperphosphorylated tau in neurons and glia. |
2023-09-28 |
2023-10-07 |
cat |
| Francesco Panza, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Roberta Stallone, Nicoletta Cirillo, Christian Damiani, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vincenzo Solfrizzi, Madia Lozupon. Clinical Development of Passive Tau-Based Immunotherapeutics for Treating Primary and Secondary Tauopathies. Expert opinion on investigational drugs. 2023-07-05. PMID:37405389. |
tauopathies are clinicopathological entities with increased and pathological deposition in glia and/or neurons of hyperphosphorylated aggregates of the microtubule-binding protein tau. |
2023-07-05 |
2023-08-14 |
Not clear |
| Connor Langworth-Green, Saisha Patel, Zane Jaunmuktane, Edwin Jabbari, Huw Morris, Maria Thom, Andrew Lees, John Hardy, Michael Zandi, Karen Duf. Chronic effects of inflammation on tauopathies. The Lancet. Neurology. vol 22. issue 5. 2023-04-14. PMID:37059510. |
tauopathies are a heterogeneous group of neurodegenerative disorders that are characterised by the aggregation of the microtubule-associated protein tau into filamentous inclusions within neurons and glia. |
2023-04-14 |
2023-08-14 |
Not clear |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-08-14 |
Not clear |
| Marta Caamaño-Moreno, Ricardo Gargin. Tauopathies: the role of tau in cellular crosstalk and synaptic dysfunctions. Neuroscience. 2022-03-10. PMID:35272005. |
in this way, this review shows how tau inclusions in glia influence the synaptic dysfunctions that result in the cognitive symptoms characteristic of tauopathies. |
2022-03-10 |
2023-08-13 |
Not clear |
| Aviva M Tolkovsky, Maria Grazia Spillantin. Tau aggregation and its relation to selected forms of neuronal cell death. Essays in biochemistry. 2021-12-13. PMID:34897457. |
although alzheimer's disease (ad) is the most prevalent tauopathy, tauopathies comprise an array of over 30 diseases in which the cytoplasmic protein tau aggregates in neurons, and also, in some diseases, in glia. |
2021-12-13 |
2023-08-13 |
Not clear |
| M Catarina Silva, Stephen J Haggart. Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255694. |
tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (mapt) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. |
2021-03-05 |
2023-08-13 |
Not clear |
| Justyna Zareba-Paslawska, Kalicharan Patra, Luca Kluzer, Tamas Revesz, Per Svenningsso. Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice. Frontiers in neurology. vol 11. 2021-02-02. PMID:33519674. |
the aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies. |
2021-02-02 |
2023-08-13 |
mouse |
| b' Elisabetta Lauretti, Ozlem Dincer, Domenico Pratic\\xc3\\xb. Regional and temporal miRNAs expression profile in a transgenic mouse model of tauopathy: implication for its pathogenesis. Molecular psychiatry. 2021-01-26. PMID:31988432.' |
studies have shown that the expression level of different micrornas (mirnas) is altered in neurodegenerative disorders including tauopathies, a group of diseases pathologically defined by accumulation of tau protein in neurons and glia cells. |
2021-01-26 |
2023-08-13 |
mouse |
| Sneha Narasimhan, Lakshmi Changolkar, Dawn M Riddle, Alexandra Kats, Anna Stieber, Sarah A Weitzman, Bin Zhang, Zhiyong Li, Erik D Roberson, John Q Trojanowski, Virginia M Y Le. Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of experimental medicine. vol 217. issue 2. 2020-09-09. PMID:31826239. |
tauopathies are characterized by abnormal accumulation of tau protein in neurons and glia. |
2020-09-09 |
2023-08-13 |
mouse |
| Dah-Eun Chloe Chung, Yari Carlomagno, Casey N Cook, Karen Jansen-West, Lillian Daughrity, Laura J Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W Dickson, Leonard Petrucell. Tau exhibits unique seeding properties in globular glial tauopathy. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30845985. |
tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. |
2020-03-30 |
2023-08-13 |
Not clear |
| Jürgen Götz, Glenda Halliday, Rebecca M Nisbe. Molecular Pathogenesis of the Tauopathies. Annual review of pathology. vol 14. 2020-03-04. PMID:30355155. |
the tauopathies constitute a group of diseases that have tau inclusions in neurons or glia as their common denominator. |
2020-03-04 |
2023-08-13 |
Not clear |
| Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J James, Pyry Koivula, John Q Trojanowski, Amos B Smith, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30404654. |
alzheimer's disease (ad) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. |
2019-04-12 |
2023-08-13 |
mouse |
| Mansi R Khanna, Jane Kovalevich, Virginia M-Y Lee, John Q Trojanowski, Kurt R Brunde. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 12. issue 10. 2017-10-30. PMID:27751442. |
tau is normally a microtubule (mt)-associated protein that appears to play an important role in ensuring proper axonal transport, but in tauopathies tau becomes hyperphosphorylated and disengages from mts, with consequent misfolding and deposition into inclusions that mainly affect neurons but also glia. |
2017-10-30 |
2023-08-13 |
Not clear |
| Jennifer S Yokoyama, Celeste M Karch, Chun C Fan, Luke W Bonham, Naomi Kouri, Owen A Ross, Rosa Rademakers, Jungsu Kim, Yunpeng Wang, Günter U Höglinger, Ulrich Müller, Raffaele Ferrari, John Hardy, Parastoo Momeni, Leo P Sugrue, Christopher P Hess, A James Barkovich, Adam L Boxer, William W Seeley, Gil D Rabinovici, Howard J Rosen, Bruce L Miller, Nicholas J Schmansky, Bruce Fischl, Bradley T Hyman, Dennis W Dickson, Gerard D Schellenberg, Ole A Andreassen, Anders M Dale, Rahul S Desika. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28271184. |
corticobasal degeneration (cbd), progressive supranuclear palsy (psp) and a subset of frontotemporal dementia (ftd) are neurodegenerative disorders characterized by tau inclusions in neurons and glia (tauopathies). |
2017-04-20 |
2023-08-13 |
human |
| Pawel Tacik, Monica Sanchez-Contreras, Rosa Rademakers, Dennis W Dickson, Zbigniew K Wszole. Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories. Neuro-degenerative diseases. vol 16. issue 1-2. 2016-09-20. PMID:26550830. |
tauopathies are a group of neurodegenerative disorders characterized by the pathological accumulation of hyperphosphorylated and insoluble tau protein within neurons and glia. |
2016-09-20 |
2023-08-13 |
Not clear |
| Bess Frost, Jürgen Götz, Mel B Fean. Connecting the dots between tau dysfunction and neurodegeneration. Trends in cell biology. vol 25. issue 1. 2015-08-17. PMID:25172552. |
tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. |
2015-08-17 |
2023-08-13 |
Not clear |
| Takahiko Tokud. [Differential diagnosis of corticobasal syndrome (CBS) and its biomarkers]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291870. |
abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and cbd is thus considered one of the tauopathies. |
2015-04-13 |
2023-08-12 |
Not clear |
| Takahiko Tokud. [Biomarkers for the differential diagnosis of corticobasal syndrome]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 1. 2013-09-03. PMID:23300103. |
abnormal accumulations of the microtubule-associated tau protein are found in both neurons and glia, and cbd is thus considered one of the tauopathies. |
2013-09-03 |
2023-08-12 |
Not clear |