| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Zhou, Jing Pan, Kai Xu, Chenghui Yan, Jing Yuan, Haixu Song, Yaling Ha. Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster. Scientific reports. vol 14. issue 1. 2024-04-24. PMID:38654053. |
we identified a cell subcluster named c5 that exhibited a close association with mitochondrial malfunction and cellular apoptosis characteristics, and identified slc25a4 as a significant biomarker of c5. |
2024-04-24 |
2024-04-26 |
Not clear |
| Hammad Alam, Vartika Srivastava, Windy Sekgele, Mohmmad Younus Wani, Abdullah Saad Al-Bogami, Julitha Molepo, Aijaz Ahma. Cellular apoptosis and cell cycle arrest as potential therapeutic targets for eugenol derivatives in Candida auris. PloS one. vol 18. issue 6. 2023-06-22. PMID:37343020. |
apoptotic indicators, such as phosphatidylserine externalization, dna fragmentation, mitochondrial depolarization, decreased cytochrome c and oxidase activity and cell death confirmed that c5 caused apoptosis in c. auris isolates. |
2023-06-22 |
2023-08-14 |
Not clear |
| Hao Li, Qingshun Q Li, Yiling Hon. Global gene expression signatures in response to citrate-coated silver nanoparticles exposure. Toxicology. vol 461. 2021-09-20. PMID:34403730. |
kegg pathway analyse showed that the most significantly impacted pathways were c5 isoprenoid, axon guidance, notch, wnt, ras-mapk signalling pathways, lysosome, and apoptosis. |
2021-09-20 |
2023-08-13 |
human |
| Junmiao Wu, Tongfu Yang, Xiaojun Wang, Wenjuan Li, Min Pang, Hongbin Sun, Hong Liang, Feng Yan. Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex. Dalton transactions (Cambridge, England : 2003). vol 50. issue 31. 2021-08-11. PMID:34313274. |
multiple mechanisms underlie the antitumor effect of c5, and they include acting against dna, inducing apoptosis, and inhibiting the activities of anti-apoptotic bcl-xl protein, metalloproteinase mmp2 and topoisomerase ii. |
2021-08-11 |
2023-08-13 |
Not clear |
| Hyo-Jin Kim, Bo-Gyeong Seo, Kwang Dong Kim, Jiyun Yoo, Joon-Hee Lee, Byung-Sun Min, Jeong-Hyung Lee, Cheol Hwangb. C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells. International journal of molecular sciences. vol 21. issue 4. 2020-11-20. PMID:32075108. |
in this study, it was found that c5 (3β-acetyl-nor-erythrophlamide), a compound of cassaine diterpene amine from erythrophleum fordii, induced cell apoptosis in a variety of types of cancer cells. |
2020-11-20 |
2023-08-13 |
human |
| Hyo-Jin Kim, Bo-Gyeong Seo, Kwang Dong Kim, Jiyun Yoo, Joon-Hee Lee, Byung-Sun Min, Jeong-Hyung Lee, Cheol Hwangb. C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells. International journal of molecular sciences. vol 21. issue 4. 2020-11-20. PMID:32075108. |
it was also found that treatment of cancer cells with a caspase-8 inhibitor significantly suppressed c5-induced apoptosis; however, treatment with caspase-9 inhibitors did not affect c5-induced apoptosis, suggesting that c5 may induce apoptosis via the extrinsic pathway by activating caspase-8. |
2020-11-20 |
2023-08-13 |
human |
| Hyo-Jin Kim, Bo-Gyeong Seo, Kwang Dong Kim, Jiyun Yoo, Joon-Hee Lee, Byung-Sun Min, Jeong-Hyung Lee, Cheol Hwangb. C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells. International journal of molecular sciences. vol 21. issue 4. 2020-11-20. PMID:32075108. |
c5, a cassaine diterpenoid amine, induces apoptosis via the extrinsic pathways in human lung cancer cells and human lymphoma cells. |
2020-11-20 |
2023-08-13 |
human |
| Hyo-Jin Kim, Bo-Gyeong Seo, Kwang Dong Kim, Jiyun Yoo, Joon-Hee Lee, Byung-Sun Min, Jeong-Hyung Lee, Cheol Hwangb. C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells. International journal of molecular sciences. vol 21. issue 4. 2020-11-20. PMID:32075108. |
in conclusion, c5 could be utilized as a new useful lead compound for the development of an anti-cancer agent that has the goal of apoptosis. |
2020-11-20 |
2023-08-13 |
human |
| Hyo-Jin Kim, Bo-Gyeong Seo, Kwang Dong Kim, Jiyun Yoo, Joon-Hee Lee, Byung-Sun Min, Jeong-Hyung Lee, Cheol Hwangb. C5, A Cassaine Diterpenoid Amine, Induces Apoptosis via the Extrinsic Pathways in Human Lung Cancer Cells and Human Lymphoma Cells. International journal of molecular sciences. vol 21. issue 4. 2020-11-20. PMID:32075108. |
induction of apoptosis in cancer cells by c5 was inversely related to the level of bcl-2 expression. |
2020-11-20 |
2023-08-13 |
human |
| Ping Yu, Jungang Deng, Jinhua Cai, Zhenlei Zhang, Juzheng Zhang, Muhammad Hamid Khan, Hong Liang, Feng Yan. Anticancer and biological properties of a Zn-2,6-diacetylpyridine bis(thiosemicarbazone) complex. Metallomics : integrated biometal science. vol 11. issue 8. 2020-06-22. PMID:31267119. |
we subsequently determined the multiple anticancer mechanisms of c5 to t-24 cells, including inhibiting the activity of topoisomerase i (topo i), blocking the cell cycle in the s phase, and inducing apoptosis and autophagy in t-24 cells. |
2020-06-22 |
2023-08-13 |
human |
| Pengfei Zhang, Caifeng Bi, Sara M Schmitt, Xin Li, Yuhua Fan, Nan Zhang, Q Ping Do. Metal-based 2,3-indolinedione derivatives as proteasome inhibitors and inducers of apoptosis in human cancer cells. International journal of molecular medicine. vol 34. issue 3. 2015-03-30. PMID:25017797. |
the results revealed that the complexes, c1, c3 and c5, but not their counterparts, c2, c4 and c6, inhibited the chymotrypsin-like activity of the human cancer cellular 26s proteasome; in addition, these complexes promoted the accumulation of the proteasome target protein, bax, inhibited cell growth and induced apoptosis in a concentration- and time-dependent manner due to their unique structures. |
2015-03-30 |
2023-08-13 |
human |
| Gabriela V Levy, Laura M Tasso, Silvia A Longhi, Hernán García Rivello, Ville Kytö, Pekka Saukko, Mariano J Levin, Karina A Góme. Antibodies against the Trypanosoma cruzi ribosomal P proteins induce apoptosis in HL-1 cardiac cells. International journal for parasitology. vol 41. issue 6. 2011-08-02. PMID:21255576. |
in this study, we report that a monoclonal ab against the r13 peptide, called mab 17.2, and its single-chain fv fragment (scfv), c5, caused apoptosis of murine adult cardiac hl-1 cells, and this effect was inhibited by pre-incubation with the β-blocker, propranolol. |
2011-08-02 |
2023-08-12 |
Not clear |
| S-M Hwang, J Li, N-Y Koo, S-Y Choi, S J Lee, S-B Oh, R Castro, J-S Kim, K Par. Role of purinergic receptor in alpha fodrin degradation in Par C5 cells. Journal of dental research. vol 88. issue 10. 2009-11-02. PMID:19783801. |
the following experiments utilized par c5 cells to examine the role of p2x7 receptor (p2x7r) in apoptosis, particularly in the cleavage and release of alpha-fodrin, an apparent ss autoantigen. |
2009-11-02 |
2023-08-12 |
Not clear |
| Jyh-Ming Chow, Guan-Cheng Huang, Shing-Chuan Shen, Chin-Yen Wu, Cheng-Wei Lin, Yen-Chou Che. Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. Journal of cellular biochemistry. vol 103. issue 5. 2008-07-16. PMID:17955493. |
results suggested that oh at c5 and c7 is essential for both the apoptosis-inducing activity of flavonoids, and oh at c8 may contribute to apoptosis induction ability. |
2008-07-16 |
2023-08-12 |
human |
| Cornelia Cudrici, Teodora Niculescu, Florin Niculescu, Moon L Shin, Horea Ru. Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement. Journal of rehabilitation research and development. vol 43. issue 1. 2007-09-20. PMID:16847778. |
by inducing eae in c5-deficient mice, we showed that complement c5 promotes axon preservation and new myelin formation, which protect olgs from apoptosis. |
2007-09-20 |
2023-08-12 |
mouse |
| Ani J Fleisig, Edward D Verrie. Pexelizumab -- a C5 complement inhibitor for use in both acute myocardial infarction and cardiac surgery with cardiopulmonary bypass. Expert opinion on biological therapy. vol 5. issue 6. 2006-09-28. PMID:15952913. |
in animal models c5 inhibition has been found to significantly reduce myocardial infarct size and decrease cellular necrosis and apoptosis. |
2006-09-28 |
2023-08-12 |
Not clear |
| Ching Huai Ko, Shing-Chuan Shen, Chun-Sen Hsu, Yen-Chou Che. Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochemical pharmacology. vol 69. issue 6. 2005-04-12. PMID:15748703. |
results of sar studies showed that the presence of oh at c3', c4', and c5' is important for the apoptosis-inducing activities of me, and that me induces apoptosis in another leukemia cell line, jurkat cells, but not in primary human polymorphonuclear (pmn) cells or in murine peritoneal macrophages (pms). |
2005-04-12 |
2023-08-12 |
human |
| Teodora Niculescu, Susanna Weerth, Florin Niculescu, Cornelia Cudrici, Violeta Rus, Cedric S Raine, Moon L Shin, Horea Ru. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 9. 2004-08-17. PMID:15100315. |
in this study, we investigated the role of c5 in apoptosis in myelin-induced eae. |
2004-08-17 |
2023-08-12 |
mouse |
| Teodora Niculescu, Susanna Weerth, Florin Niculescu, Cornelia Cudrici, Violeta Rus, Cedric S Raine, Moon L Shin, Horea Ru. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 9. 2004-08-17. PMID:15100315. |
effects of complement c5 on apoptosis in experimental autoimmune encephalomyelitis. |
2004-08-17 |
2023-08-12 |
mouse |
| Teodora Niculescu, Susanna Weerth, Florin Niculescu, Cornelia Cudrici, Violeta Rus, Cedric S Raine, Moon L Shin, Horea Ru. Effects of complement C5 on apoptosis in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 9. 2004-08-17. PMID:15100315. |
together, these findings are consistent with the role of c5, possibly by forming the membrane attack complex, in limiting olg apoptosis in eae, thus promoting remyelination during recovery. |
2004-08-17 |
2023-08-12 |
mouse |