| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Jiezhao Lin, Yuanfang Sun, Bin Xia, Yihan Wang, Changnan Xie, Jinfeng Wang, Jinwei Hu, Lixin Zh. Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury. Neuroscience bulletin. 2024-04-09. PMID:38592581. |
overexpression of mertk upregulated tight junction proteins (tjs), reducing bscb permeability and subsequently inhibiting inflammation and apoptosis. |
2024-04-09 |
2024-04-11 |
Not clear |
| Aaron Silva-Sanchez, Selene Meza-Perez, Mingyong Liu, Sara L Stone, Leopoldo Flores-Romo, Eric Ubil, Frances E Lund, Alexander F Rosenberg, Troy D Randal. Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. Science immunology. vol 8. issue 84. 2023-06-16. PMID:37327322. |
activation of regulatory dendritic cells by mertk coincides with a temporal wave of apoptosis in neonatal lungs. |
2023-06-16 |
2023-08-14 |
Not clear |
| Maaike Schilperoort, David Ngai, Marina Katerelos, David A Power, Ira Taba. PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages. Nature metabolism. 2023-02-16. PMID:36797420. |
mice transplanted with activation-defective pfkfb2 bone marrow and then subjected to dexamethasone-induced thymocyte apoptosis exhibit impaired thymic efferocytosis, increased thymic necrosis, and lower expression of the efferocytosis receptors mertk and lrp1 on thymic macrophages compared with wild-type control mice. |
2023-02-16 |
2023-08-14 |
mouse |
| Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Che. Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression. Transplantation. 2022-05-12. PMID:35546091. |
axl is a member of the tyro3, axl, mertk family and is involved in immune and apoptosis processes in multiple organs. |
2022-05-12 |
2023-08-13 |
Not clear |
| Divya Sekar, Christina Dillmann, Evelyn Sirait-Fischer, Annika F Fink, Aleksandra Zivkovic, Natalie Baum, Elisabeth Strack, Stephan Klatt, Sven Zukunft, Stefan Wallner, Arnaud Descot, Catherine Olesch, Priscila da Silva, Andreas von Knethen, Tobias Schmid, Sabine Grösch, Rajkumar Savai, Nerea Ferreirós, Ingrid Fleming, Sourav Ghosh, Carla V Rothlin, Holger Stark, Hind Medyouf, Bernhard Brüne, Andreas Weiger. Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation. Cancer research. vol 82. issue 8. 2022-04-15. PMID:35425959. |
ptdss1-deficient tumor cells exposed less ps during apoptosis, which was recognized by the ps receptor mertk. |
2022-04-15 |
2023-08-13 |
mouse |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Lu Qingxian, Li Qiutang, Lu Qingju. Regulation of phagocytosis by TAM receptors and their ligands. Frontiers in biology. vol 5. issue 3. 2021-10-20. PMID:21057587. |
mutations in the mertk single gene or in different combinations of the double or triple gene mutations in the same cell cause complete or partial impairment in phagocytosis of their preys; and as a result, either the normal apoptotic cells cannot be efficiently removed or the tissue neighbor cells die by apoptosis. |
2021-10-20 |
2023-08-12 |
Not clear |
| Ayako Sayama, Keiko Okado, Mayu Yamaguchi, Naozumi Samata, Masako Imaoka, Kiyonori Kai, Kazuhiko Mor. The Impact of the Timing of Dosing on the Severity of UNC569-Induced Ultrastructural Changes in the Mouse Retina. Toxicologic pathology. vol 48. issue 5. 2021-05-26. PMID:32538308. |
these results suggest that the timing of the dosing in relation to the physiological mertk phosphorylation affected the severity of changes in the rpe, leading to the apoptosis of the photoreceptor cells. |
2021-05-26 |
2023-08-13 |
mouse |
| Katherine A Minson, Catherine C Smith, Deborah DeRyckere, Clara Libbrecht, Alisa B Lee-Sherick, Madeline G Huey, Elisabeth A Lasater, Gregory D Kirkpatrick, Michael A Stashko, Weihe Zhang, Craig T Jordan, Dmitri Kireev, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Neil P Shah, Douglas K Graha. The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI insight. vol 1. issue 3. 2019-11-20. PMID:27158668. |
mrx-2843 treatment induces apoptosis and inhibits colony formation in aml cell lines and primary patient samples expressing mertk and/or flt3-itd, with a wide therapeutic window compared with that of normal human cord blood cells. |
2019-11-20 |
2023-08-13 |
human |
| Thomas A Werfel, David L Elion, Bushra Rahman, Donna J Hicks, Violeta Sanchez, Paula I Gonzales-Ericsson, Mellissa J Nixon, Jamaal L James, Justin M Balko, Peggy A Scherle, Holly K Koblish, Rebecca S Coo. Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1. Cancer research. vol 79. issue 1. 2019-10-21. PMID:30413412. |
treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through mertk and ido1. |
2019-10-21 |
2023-08-13 |
Not clear |
| Ayako Sayama, Keiko Okado, Koichi Nakamura, Tatsuya Kawaguchi, Takuma Iguchi, Toshihiko Makino, Koichi Yabe, Kiyonori Kai, Kazuhiko Mor. UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice. Toxicologic pathology. vol 46. issue 2. 2018-12-11. PMID:29310530. |
these results suggest that mertk inhibition impaired phagocytic function of the retina, leading to accumulation of shed pos within the pos layer and increasing phagosomes and phagolysosomes in the rpe to delay pos renewal, resulting in apoptosis of photoreceptor cells. |
2018-12-11 |
2023-08-13 |
mouse |
| Giovanni Musso, Maurizio Cassader, Franco De Michieli, Elena Paschetta, Silvia Pinach, Francesca Saba, Daria Bongiovanni, Luciana Framarin, Mara Berrutti, Nicola Leone, Stefania Corvisieri, Renato Parente, Federica Molinaro, Antonio Sircana, Simona Bo, Roberto Gambin. MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat. Human molecular genetics. vol 26. issue 9. 2017-10-17. PMID:28334911. |
despite comparable fastign and postprandial lipid profiles, mertk a-allele carriers showed lower resistin and mcp-1 responses, milder mnc nf-κb activation, and a higher postprandial adiponectin response to fat, which predicted tissue insulin resistance hepatocyte apoptosis and liver histology. |
2017-10-17 |
2023-08-13 |
human |
| Lakshmi Mundkur, Rupak Mukhopadhyay, Sonia Samson, Meenakshi Varma, Dnyaneswar Kale, Daxin Chen, Sneha Shivaprasad, Hemapriya Sivanandan, Vinod Soman, Xinjie Lu, Vijay V Kakka. Mucosal tolerance to a combination of ApoB and HSP60 peptides controls plaque progression and stabilizes vulnerable plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J mice. PloS one. vol 8. issue 3. 2013-09-06. PMID:23505495. |
tolerance with continued hypercholesterolemia resulted in 60.8% reduction in necrotic core area suggesting plaque stabilization, which was supported by reduction in apoptosis and increased efferocytosis demonstrated by greater expression of receptor tyrosine kinase mer (mertk) in the plaque. |
2013-09-06 |
2023-08-12 |
mouse |
| Y Wang, G Moncayo, P Morin, G Xue, M Grzmil, M M Lino, V Clément-Schatlo, S Frank, A Merlo, B A Hemming. Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme. Oncogene. vol 32. issue 7. 2013-04-12. PMID:22469987. |
finally, dna damage robustly triggers the upregulation and phosphorylation of mertk, which protects cells from apoptosis. |
2013-04-12 |
2023-08-12 |
Not clear |
| Melissa Sandahl, Debra M Hunter, Karen E Strunk, H Shelton Earp, Rebecca S Coo. Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation. BMC developmental biology. vol 10. 2011-04-14. PMID:21192804. |
mertk expression, apoptosis and the accumulation of apoptotic debris were examined in histological sections of mertk-deficient, axl/tyro3-deficient, and wild-type mammary glands harvested at specific time points during lactation and synchronized involution. |
2011-04-14 |
2023-08-12 |
mouse |
| Angeliki Kazeros, Ben-Gary Harvey, Brendan J Carolan, Holly Vanni, Anja Krause, Ronald G Crysta. Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. American journal of respiratory cell and molecular biology. vol 39. issue 6. 2008-11-28. PMID:18587056. |
this up-regulation of mertk may reflect an increased demand for removal of apoptotic cells in smokers, an observation with implications for the development of chronic obstructive pulmonary disease, a disorder associated with dysregulated apoptosis of lung parenchymal cells. |
2008-11-28 |
2023-08-12 |
human |
| Jill C Todt, Bin Hu, Jeffrey L Curti. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. Journal of leukocyte biology. vol 84. issue 2. 2008-09-04. PMID:18511575. |
we induced apoptosis in murine thymocytes by dexamethasone and used western blotting and immunoprecipitation to analyze the interaction of mertk and sr-a in the j774a.1 (j774) murine mø cell line and in peritoneal mø of wild-type mice and sr-a-/- mice. |
2008-09-04 |
2023-08-12 |
mouse |