| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Xi Zhang, Ying Li, Jun Chun Tang, Kai Qing Li, Juan Juan Shen, Chang Liu, Yong Hua Jiang, Zi Ping Zhang, Yi Lei Wang, Peng Fei Zo. SARM suppresses TRIF, TRAF3, and IRF3/7 mediated antiviral signaling in large yellow croaker Frontiers in immunology. vol 13. 2023-01-30. PMID:36713393. |
sarm suppresses trif, traf3, and irf3/7 mediated antiviral signaling in large yellow croaker as a tir domain-containing molecular, sterile α-and armadillo motif-containing protein (sarm) acts as an adaptor in toll-like receptor (tlr) signaling, and also plays important roles in mediating apoptosis and neuronal injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yu Gong, Lin Zou, Dongzhi Cen, Wei Chao, Dunjin Che. Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis. Inflammation. vol 39. issue 6. 2017-04-04. PMID:27590237. |
sterile α and heat/armadillo motif-containing protein (sarm) is implicated in the regulation of immune cell apoptosis. |
2017-04-04 |
2023-08-13 |
mouse |
| Yu Gong, Lin Zou, Dongzhi Cen, Wei Chao, Dunjin Che. Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis. Inflammation. vol 39. issue 6. 2017-04-04. PMID:27590237. |
conclusions these findings suggest that sarm is a potential regulator of sepsis-induced splenocyte apoptosis. |
2017-04-04 |
2023-08-13 |
mouse |
| Yu Gong, Lin Zou, Dongzhi Cen, Wei Chao, Dunjin Che. Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis. Inflammation. vol 39. issue 6. 2017-04-04. PMID:27590237. |
moreover, the attenuation of sarm expression synchronized with splenocyte apoptosis, as evidenced by increased caspase 3 cleavage and atp depletion. |
2017-04-04 |
2023-08-13 |
mouse |
| Porkodi Panneerselvam, Jeak Ling Din. Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development. International reviews of immunology. vol 34. issue 5. 2016-06-30. PMID:26268046. |
recent studies have highlighted the significant functional role of sarm in mediating apoptosis and antiviral innate immune response. |
2016-06-30 |
2023-08-13 |
Not clear |
| Porkodi Panneerselvam, Jeak Ling Din. Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development. International reviews of immunology. vol 34. issue 5. 2016-06-30. PMID:26268046. |
beyond tlr signaling—the role of sarm in antiviral immune defense, apoptosis & development. |
2016-06-30 |
2023-08-13 |
Not clear |
| Chad R Sethman, Jacek Hawige. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PloS one. vol 8. issue 7. 2014-08-21. PMID:23923041. |
these findings indicate an important link between the innate immunity adaptor sarm and stabilization of nuclear lamins during inflammation-driven apoptosis in human cells. |
2014-08-21 |
2023-08-12 |
human |
| Chad R Sethman, Jacek Hawige. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PloS one. vol 8. issue 7. 2014-08-21. PMID:23923041. |
sterile alpha and armadillo-motif containing protein (sarm), a highly conserved and structurally unique member of the myd88 family of toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis. |
2014-08-21 |
2023-08-12 |
human |
| Shalini Sethurathinam, Laishram Pradeepkumar Singh, Porkodi Panneerselvam, Bernadette Byrne, Jeak Ling Din. UXT plays dual opposing roles on SARM-induced apoptosis. FEBS letters. vol 587. issue 20. 2013-11-22. PMID:24021647. |
we found that the uxt isoforms elicit dual opposing regulatory effects on sarm-induced apoptosis; while uxt v1, co-expressed with sarm, caused a reduction in caspase 8 activity, uxt v2 strongly increased caspase 8 activity and enhanced sarm-induced apoptosis by activating the extrinsic pathway and depolarizing the mitochondria. |
2013-11-22 |
2023-08-12 |
Not clear |
| Shalini Sethurathinam, Laishram Pradeepkumar Singh, Porkodi Panneerselvam, Bernadette Byrne, Jeak Ling Din. UXT plays dual opposing roles on SARM-induced apoptosis. FEBS letters. vol 587. issue 20. 2013-11-22. PMID:24021647. |
since sarm is a tlr adaptor which induces intrinsic apoptosis following immune activation, we were prompted to query whether uxt and sarm might co-regulate apoptosis. |
2013-11-22 |
2023-08-12 |
Not clear |
| P Panneerselvam, L P Singh, V Selvarajan, W J Chng, S B Ng, N S Tan, B Ho, J Chen, J L Din. T-cell death following immune activation is mediated by mitochondria-localized SARM. Cell death and differentiation. vol 20. issue 3. 2013-08-15. PMID:23175186. |
mechanistically, sarm mediates intrinsic apoptosis via b cell lymphoma-2 (bcl-2) family members. |
2013-08-15 |
2023-08-12 |
Not clear |
| P Panneerselvam, L P Singh, V Selvarajan, W J Chng, S B Ng, N S Tan, B Ho, J Chen, J L Din. T-cell death following immune activation is mediated by mitochondria-localized SARM. Cell death and differentiation. vol 20. issue 3. 2013-08-15. PMID:23175186. |
the mitochondria-localized sarm triggers intrinsic apoptosis by generating reactive oxygen species and depolarizing the mitochondrial potential. |
2013-08-15 |
2023-08-12 |
Not clear |
| Porkodi Panneerselvam, Laishram Pradeepkumar Singh, Bow Ho, Jianzhu Chen, Jeak Ling Din. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. The Biochemical journal. vol 442. issue 2. 2012-04-09. PMID:22145856. |
the fifth and the most well-conserved member of the tlr (toll-like receptor) adaptor, sarm (sterile α- and heat/armadillo-motif-containing protein), has been reported to be an important mediator of apoptosis. |
2012-04-09 |
2023-08-12 |
Not clear |
| William J Kaiser, Margaret K Offerman. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 8. 2005-05-17. PMID:15814722. |
in this study, we investigated the control of apoptosis by the tir domain-containing adapter proteins myd88, tir-domain containing adapter protein (tirap), tir-domain-containing adapter-inducing ifn-beta (trif), trif-related adapter molecule (tram), and sterile alpha motifs and beta-catenin/armadillo repeats (sarm). |
2005-05-17 |
2023-08-12 |
Not clear |