| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Zhang Liwen, Jiang Song, Jingsong Shi, Xiaodong Xu, Ling Wang, Zhai Xiuwen, Qin Hou, Qin Weisong, Zhaohong Che. TYRO3 protects podocyte via JNK/c-jun-P53 pathway. Archives of biochemistry and biophysics. 2023-03-22. PMID:36948351. |
moreover, knockdown of tyro3 expression with sirna induced podocytes apoptosis and cytoskeleton rearrangement. |
2023-03-22 |
2023-08-14 |
zebrafish |
| Kazushi Hara, Yosuke Horikoshi, Masaki Morimoto, Kazuhiro Nakaso, Teppei Sunaguchi, Tatsuyuki Kurashiki, Yuji Nakayama, Takehiko Hanaki, Manabu Yamamoto, Teruhisa Sakamoto, Yoshiyuki Fujiwara, Tatsuya Matsur. TYRO3 promotes chemoresistance via increased LC3 expression in pancreatic cancer. Translational oncology. vol 28. 2022-12-28. PMID:36577166. |
tyro3 knockdown decreased cell viability and enhanced apoptosis following treatment of pc cells with gemcitabine and 5-fluorouracil (5-fu). |
2022-12-28 |
2023-08-14 |
mouse |
| Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Che. Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression. Transplantation. 2022-05-12. PMID:35546091. |
axl is a member of the tyro3, axl, mertk family and is involved in immune and apoptosis processes in multiple organs. |
2022-05-12 |
2023-08-13 |
Not clear |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Hae Dong Kim, Eun Jung Park, Eun Kyoung Choi, Seuk Young Song, Kwang-Lae Hoe, Dong-Uk Ki. G-749 Promotes Receptor Tyrosine Kinase TYRO3 Degradation and Induces Apoptosis in Both Colon Cancer Cell Lines and Xenograft Mouse Models. Frontiers in pharmacology. vol 12. 2021-11-02. PMID:34721022. |
g-749 promotes receptor tyrosine kinase tyro3 degradation and induces apoptosis in both colon cancer cell lines and xenograft mouse models. |
2021-11-02 |
2023-08-13 |
mouse |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
axl, a member of the tam (tyro3, axl, mer) receptor tyrosine kinase family, plays critical roles in cell growth, proliferation, apoptosis, and migration. |
2021-03-29 |
2023-08-13 |
Not clear |
| Nour Al Kafri, Sassan Hafiz. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis. Cancers. vol 11. issue 12. 2020-09-28. PMID:31766614. |
in addition, pros1 protected cancer cells from acute apoptosis induced by staurosporine, as well as additionally, long-term serum starvation-induced apoptosis in mgh-u3 cells (tyro3 only), which reflects its additional coupling to akt signalling in these cells. |
2020-09-28 |
2023-08-13 |
human |
| Florent Dufour, Linda Silina, Hélène Neyret-Kahn, Aura Moreno-Vega, Clémentine Krucker, Narjesse Karboul, Marion Dorland-Galliot, Pascale Maillé, Elodie Chapeaublanc, Yves Allory, Nicolas Stransky, Hélène Haegel, Thierry Menguy, Vanessa Duong, François Radvanyi, Isabelle Bernard-Pierro. TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer. British journal of cancer. vol 120. issue 5. 2019-12-10. PMID:30765874. |
tyro3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer. |
2019-12-10 |
2023-08-13 |
Not clear |
| Cheng Huang, Yu-Ling Huang, Chia-Chi Wang, Yi-Ling Pan, Yu-Heng Lai, Hsiu-Chen Huan. Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells. Journal of agricultural and food chemistry. vol 67. issue 10. 2019-03-22. PMID:30789269. |
ampelopsins a and c induce apoptosis and metastasis through downregulating axl, tyro3, and fyn expressions in mda-mb-231 breast cancer cells. |
2019-03-22 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Shoutian Zhu, Heiko Wurdak, Yan Wang, Anna Galkin, Haiyan Tao, Jie Li, Costas A Lyssiotis, Feng Yan, Buu P Tu, Loren Miraglia, John Walker, Fanxiang Sun, Anthony Orth, Peter G Schultz, Xu W. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 40. 2010-01-15. PMID:19805117. |
furthermore, tyro3 knockdown represses cellular proliferation and colony formation in melanoma cells, and sensitizes them to chemotherapeutic agent-induced apoptosis; tyro3 knockdown in melanoma cells also inhibits tumorigenesis in vivo. |
2010-01-15 |
2023-08-12 |
human |
| Angela Pierce, Brian Bliesner, Mei Xu, Sheila Nielsen-Preiss, Greg Lemke, Stuart Tobet, Margaret E Wierma. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Molecular endocrinology (Baltimore, Md.). vol 22. issue 11. 2009-06-11. PMID:18787040. |
studies using caspase 3 cleavage as a marker of apoptosis showed that axl(-/-), tyro3(-/-) double-knockout mice had increased cell death in the nose and dorsal forebrain, supporting the underlying mechanism of cell loss. |
2009-06-11 |
2023-08-12 |
mouse |