| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongren Huang, Xue Liu, Liping Wang, Feng Wan. Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes. Biology of sex differences. vol 15. issue 1. 2024-04-23. PMID:38654275. |
the lateral habenula (lhb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiological functions, such as encoding value signals, integrating emotional information, and regulating related behaviors. |
2024-04-23 |
2024-04-26 |
mouse |
| Miseon Kang, Jun-Mo Chung, Jihyun Noh, Jeongyeon Ki. The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model. Neurobiology of stress. vol 27. 2023-09-29. PMID:37771409. |
the lateral habenula (lhb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. |
2023-09-29 |
2023-10-07 |
Not clear |
| Zhiheng Ren, Jiawei Hou, Wenfu Li, Ying Tang, Molin Wang, Ruxuan Ding, Songlin Liu, Yixin Fu, Yunlin Mai, Jianxun Xia, Wanhong Zuo, Li-Hua Zhou, Jiang-Hong Ye, Rao F. LPA1 receptors in the lateral habenula regulate negative affective states associated with alcohol withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-04-14. PMID:37059867. |
recent studies suggest that lhb is involved in a negative emotional state during alcohol withdrawal, which can lead to relapse. |
2023-04-14 |
2023-08-14 |
rat |
| Guang-Ming Zhang, Hong-Yun Wu, Wen-Qiang Cui, Wei Pen. Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence. Frontiers in psychiatry. vol 13. 2022-11-17. PMID:36386995. |
as a crucial relay in brain networks associated with emotion regulation, lhb receives excitatory or inhibitory projections from upstream brain regions related to stress and cognition and interacts with brain regions involved in emotion regulation. |
2022-11-17 |
2023-08-14 |
Not clear |
| Zi-Fan Zhuang, Hong-Yun Wu, Ya-Yi Song, Lei Li, Xia Cui, Jie Yang, Xiang-Qing Xu, Wen-Qiang Cu. N-Methyl D-aspartate receptor subtype 2B/Ca Frontiers in cellular neuroscience. vol 16. 2022-10-03. PMID:36187288. |
the lateral habenula (lhb) plays important roles in the modulation of pain and emotion. |
2022-10-03 |
2023-08-14 |
mouse |
| Jingsheng Gu, Zhijie Hou, Xiaotao Zhou, Qinglei Wang, Yanmei Chen, Jichuan Zhan. Activation of 5-HT Neuroscience letters. 2021-10-26. PMID:34699942. |
lateral habenula (lhb) in a brain area reciprocally connects with raphe nucleus and plays important roles in emotion and depression. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sukanya G Gakare, Shejin S Varghese, Paras P Patni, Samruddhi A Wagh, Rajesh R Ugal. Prevention of glutamate excitotoxicity in lateral habenula alleviates ethanol withdrawal-induced somatic and behavioral effects in ethanol dependent mice. Behavioural brain research. vol 416. 2021-10-05. PMID:34453973. |
recent studies have also implicated the hyperactivity of lhb, adding to the emergence of negative emotional states during withdrawal from addictive drugs. |
2021-10-05 |
2023-08-13 |
mouse |
| Elahe Amohashemi, Parham Reisi, Hojjatallah Alae. Lateral habenula electrical stimulation with different intensities in combination with GABA Neuroscience letters. vol 759. 2021-08-06. PMID:34062194. |
lateral habenula electrical stimulation with different intensities in combination with gaba the lateral habenula (lhb) plays a principal role in response to aversive stimuli and negative emotional states. |
2021-08-06 |
2023-08-13 |
Not clear |
| Zi-Lin Li, Yan Wang, Hua-Wei Zou, Xiao-Yuan Jing, Ying-Juan Liu, Lai-Fu L. GABA(B) receptors within the lateral habenula modulate stress resilience and vulnerability in mice. Physiology & behavior. vol 230. 2021-06-18. PMID:33412189. |
the habenular nuclei, which consist of the medial and lateral sub-regions (mhb and lhb, respectively), have been described as a critical node in emotional regulations. |
2021-06-18 |
2023-08-13 |
mouse |
| Ryan D Shepard, Fereshteh S Nugen. Targeting Endocannabinoid Signaling in the Lateral Habenula as an Intervention to Prevent Mental Illnesses Following Early Life Stress: A Perspective. Frontiers in synaptic neuroscience. vol 13. 2021-06-15. PMID:34122037. |
the lateral habenula (lhb) has been a topic of extensive investigation in mental health disorders due to its prominent role in emotion and mood regulation through modulation of brain reward and motivational neural circuits. |
2021-06-15 |
2023-08-13 |
Not clear |
| Xin Liu, Kai-Xiang Zhou, Nan-Nan Yin, Chun-Kui Zhang, Ming-Hong Shi, Hong-Yun Zhang, Dong-Mei Wang, Zi-Jun Xu, Jing-Dong Zhang, Jin-Lian Li, Mei-Qing Wan. Malocclusion Generates Anxiety-Like Behavior Through a Putative Lateral Habenula-Mesencephalic Trigeminal Nucleus Pathway. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31427925. |
the lateral habenula (lhb) is involved in emotional modulation and has direct projections to the vme. |
2020-09-29 |
2023-08-13 |
rat |
| Dorine Tan, Alvaro Nuno-Perez, Manuel Mameli, Frank J Mey. Cocaine withdrawal reduces GABA The European journal of neuroscience. vol 50. issue 3. 2020-06-30. PMID:30118546. |
cocaine withdrawal reduces gaba lateral habenula (lhb) hyperactivity plays a pivotal role in the emergence of negative emotional states, including those occurring during withdrawal from addictive drugs. |
2020-06-30 |
2023-08-13 |
Not clear |
| Hailan Hu, Yihui Cui, Yan Yan. Circuits and functions of the lateral habenula in health and in disease. Nature reviews. Neuroscience. vol 21. issue 5. 2020-05-11. PMID:32269316. |
recently, exciting progress has been made in identifying the molecular and cellular mechanisms in the lhb that underlie negative emotional state in animal models of drug withdrawal and major depression. |
2020-05-11 |
2023-08-13 |
Not clear |
| Youichirou Ootsuka, Mazher Mohammed, William W Blessin. Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28642586. |
in conscious animals, lesioning the lhb attenuated emotional bat thermogenesis, suggesting that the lhb is part of the central circuitry mediating emotional hyperthermia. |
2018-12-31 |
2023-08-13 |
Not clear |
| Youichirou Ootsuka, Mazher Mohammed, William W Blessin. Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé. Scientific reports. vol 7. issue 1. 2018-12-31. PMID:28642586. |
we have now investigated whether the lhb mediates bat thermogenesis elicited by emotional stress, and whether the lhb modulates thermoregulatory sympathetic outflow via the rostral medullary raphé, a key integrative lower brainstem sympathetic control centre. |
2018-12-31 |
2023-08-13 |
Not clear |
| Victor Mathis, Brigitte Cosquer, Alexandra Barbelivien, Karine Herbeaux, Béatrice Bothorel, Dominique Sage-Ciocca, Vincent-Joseph Poirel, Chantal Mathis, Lucas Lecourtie. The lateral habenula interacts with the hypothalamo-pituitary adrenal axis response upon stressful cognitive demand in rats. Behavioural brain research. vol 341. 2018-09-04. PMID:29248667. |
the lateral habenula (lhb) is involved in emotional and cognitive behaviors. |
2018-09-04 |
2023-08-13 |
rat |
| Jiangping Chan, Xin Guan, Yiling Ni, Lilu Luo, Liqiang Yang, Pengyue Zhang, Jichuan Zhang, Yanmei Che. Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats. Behavioural brain research. vol 321. 2017-11-29. PMID:28025067. |
the lateral habenula (lhb) plays an important role in emotion and cognition. |
2017-11-29 |
2023-08-13 |
rat |
| Mihee Song, Yong Sang Jo, Yeon-Kyung Lee, June-Seek Cho. Lesions of the lateral habenula facilitate active avoidance learning and threat extinction. Behavioural brain research. vol 318. 2017-11-06. PMID:27732891. |
the lateral habenula (lhb) is an epithalamic brain structure that provides strong projections to midbrain monoaminergic systems that are involved in motivation, emotion, and reinforcement learning. |
2017-11-06 |
2023-08-13 |
rat |
| Jinyu Xiao, Meiying Song, Fengdan Li, Xiaofeng Liu, Alinur Anwar, Hua Zha. Effects of GABA microinjection into dorsal raphe nucleus on behavior and activity of lateral habenular neurons in mice. Experimental neurology. vol 298. issue Pt A. 2017-11-06. PMID:28843542. |
the observed decrease in lhb activity is probably due to the presence of a negative feedback loop between the drn and the lhb, which may play a role in maintaining emotional homeostasis. |
2017-11-06 |
2023-08-13 |
mouse |
| Victor Mathis, Brigitte Cosquer, Martino Avallone, Jean-Christophe Cassel, Lucas Lecourtie. Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25971591. |
they further suggest a dichotomy between the role of glutamatergic and other inputs to the lhb in hippocampus-dependent memory processing, as well as in emotional aspects of goal-directed behaviors. |
2016-08-02 |
2023-08-13 |
rat |