| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ebru Alp, Sibel Doguizi, Fadime Mutlu Icduygu, Egemen Akgun, Mehmet Ali Sekeroglu, Murat Atabey Oze. An analysis of the relationship between ABCC8 and KCNJ11 gene polymorphisms and diabetic retinopathy in Turkish population. Ophthalmic genetics. 2024-02-27. PMID:38411150. |
katp and related genes (kcnj11 and abcc8) play an important role in insulin secretion by glucose-stimulated pancreatic beta cells and the regulation of insulin secretion. |
2024-02-27 |
2024-03-02 |
Not clear |
| Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbon. Case report: Better late than never, but sooner is better: switch from CSII to sulfonylureas in two patients with neonatal diabetes due to KCNJ11 variants. Frontiers in endocrinology. vol 14. 2023-05-30. PMID:37251668. |
after the acute phase, patients with abcc8 or kcnj11 mutations treated with insulin therapy can switch to hypoglycemic sulfonylureas (su). |
2023-05-30 |
2023-08-14 |
Not clear |
| John Grizzanti, William R Moritz, Morgan C Pait, Molly Stanley, Sarah D Kaye, Caitlin M Carroll, Nicholas J Constantino, Lily J Deitelzweig, James A Snipes, Derek Kellar, Emily E Caesar, Ryan J Pettit-Mee, Stephen M Day, Jonathon P Sens, Noelle I Nicol, Jasmeen Dhillon, Maria S Remedi, Drew D Kiraly, Celeste M Karch, Colin G Nichols, David M Holtzman, Shannon L Macaule. KATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer's-related pathology. JCI insight. 2023-05-02. PMID:37129980. |
first, we demonstrate that katp channel subunits, kir6.2/kcnj11 and sur1/abcc8 are expressed on excitatory and inhibitory neurons in the human brain and cortical expression of kcnj11 and abcc8 changes with alzheimer's pathology in humans and mice. |
2023-05-02 |
2023-08-14 |
mouse |
| Chenxi Qin, Lina-Marcela Diaz-Gallo, Bowen Tang, Yunzhang Wang, Thuy-Dung Nguyen, Arvid Harder, Yi Lu, Leonid Padyukov, Johan Askling, Sara Häg. Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. European journal of epidemiology. 2023-04-13. PMID:37052755. |
corresponding ors (95%cis) were 0.83 (0.44-1.55) for genetic variation in the targets of insulin and its analogues (gene: insr), and 1.12 (0.83, 1.49) 1.25 (0.78-2.00) for genetic variation in the sulfonylurea targets (gene: abcc8 and kcnj11). |
2023-04-13 |
2023-08-14 |
Not clear |
| Vishal Musale, R Charlotte Moffett, Bosede Owolabi, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Mechanisms of action of the antidiabetic peptide [S4K]CPF-AM1 in db/db mice. Journal of molecular endocrinology. vol 66. issue 2. 2021-06-16. PMID:33252358. |
genes associated with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c, glp1r, gipr) were significantly upregulated by treatment with [s4k]cpf-am1. |
2021-06-16 |
2023-08-13 |
mouse |
| Vishal Musale, R Charlotte Moffett, J Michael Conlon, Peter R Flatt, Yasser H Abdel-Waha. Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study. Peptides. vol 136. 2021-06-10. PMID:33338546. |
peptide administration resulted in a significant (p < 0.01) increase in islet expression of the gene encoding pdx-1, a major transcription factor in islet cells determining β-cell survival and function, resulting in increased expression of genes involved with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c) together with the genes encoding the incretin receptors glp1r and gipr. |
2021-06-10 |
2023-08-13 |
mouse |
| Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovin. Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals. PloS one. vol 14. issue 11. 2020-03-24. PMID:31703101. |
in addition to universal effects, 4 clusters of functionally related genes with a subject-specific differential expression were distinguished, including genes relevant to insulin production (hnf1b, hnf1a, hnf4a, gck, ins, neurod1, pax4, pdx1, abcc8, kcnj11) and cholesterol homeostasis (apob, ldlr, pcsk9). |
2020-03-24 |
2023-08-13 |
Not clear |
| T Koblas, I Leontovyc, S Loukotová, F Saude. Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor. Folia biologica. vol 65. issue 3. 2020-03-09. PMID:31638558. |
upon the reprogramming, ipcs formed 4.6 ± 1.2 % of the total cells and expressed typical markers (insulin, glucokinase, abcc8, kcnj11, slc2a2, slc30a8) and transcription factors (pdx1, neurod1, mafa, nkx2.2, nkx6.1, pax4, pax6) needed for the proper function of pancreatic β-cells. |
2020-03-09 |
2023-08-13 |
human |
| Lisa R Letourneau, Siri Atma W Greele. Congenital forms of diabetes: the beta-cell and beyond. Current opinion in genetics & development. vol 50. 2019-03-08. PMID:29454299. |
ongoing follow-up of patients with kcnj11 and abcc8 mutations has supported the safety and efficacy of sulfonylureas, as well as the use of insulin pumps and continuous glucose monitors in infants with insulin-requiring forms of monogenic diabetes. |
2019-03-08 |
2023-08-13 |
Not clear |
| Sonya Galcheva, Sara Al-Khawaga, Khalid Hussai. Diagnosis and management of hyperinsulinaemic hypoglycaemia. Best practice & research. Clinical endocrinology & metabolism. vol 32. issue 4. 2018-12-11. PMID:30086874. |
recent advances in genetics have linked congenital hh to mutations in 14 different genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1, ppm2, cacna1d, foxa2). |
2018-12-11 |
2023-08-13 |
Not clear |
| Hüseyin Demirbilek, Khalid Hussai. Congenital Hyperinsulinism: Diagnosis and Treatment Update. Journal of clinical research in pediatric endocrinology. vol 9. issue Suppl 2. 2018-08-06. PMID:29280746. |
mutations in 12 different key genes (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1 and pmm2) that are involved in the regulation of insulin secretion from pancreatic β-cells have been described to be responsible for the underlying molecular mechanisms leading to congenital hh. |
2018-08-06 |
2023-08-13 |
Not clear |
| Opeolu O Ojo, Dinesh K Srinivasan, Bosede O Owolabi, Mary K McGahon, R Charlotte Moffett, Tim M Curtis, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance. Biological chemistry. vol 397. issue 8. 2017-06-15. PMID:26966929. |
peptide administration resulted in up-regulation of key functional genes in islets involved insulin secretion (abcc8, kcnj11, cacna1c and slc2a2) and in skeletal muscle involved with insulin action (insr, irs1, pdk1, pik3ca, and slc2a4). |
2017-06-15 |
2023-08-13 |
mouse |
| Valerio Costa, Antonio Federico, Carla Pollastro, Carmela Ziviello, Simona Cataldi, Pietro Formisano, Alfredo Ciccodicol. Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes. International journal of molecular sciences. vol 17. issue 7. 2017-03-15. PMID:27347941. |
inter-individual variability is principally due to single nucleotide polymorphisms, and differential drug responsiveness has been correlated to alteration in genes involved in drug metabolism (cyp2c9) or insulin signaling (irs1, abcc8, kcnj11 and pparg). |
2017-03-15 |
2023-08-13 |
Not clear |
| Shunyao Liao, Yunqiang Liu, Xiaojuan Chen, Yuande Tan, Jie Mei, Wenzhong Song, Lu Gan, Hailian Wang, Shi Yin, Xianjue Dong, Shu Chi, Shaoping Den. The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women. Reproductive sciences (Thousand Oaks, Calif.). vol 22. issue 11. 2016-10-05. PMID:25878199. |
by adjusting for maternal age, bmi, and the related interactions, the genetic variants in abcc8, cdkal1, cdkn2a, hnf1b, kcnj11, and mtnr1b were detected to impact gestational insulin signaling through heterogeneous mechanisms; however, compared with that in nonpregnant metabolism, the genetic effects seem to be eminently and heavily influenced by maternal age and bmi, indicating possible particular mechanisms underlying gestational metabolism and diabetic pathogenesis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Omer Babiker, Sarah E Flanagan, Sian Ellard, Hesham Al Girim, Khalid Hussain, Senthil Senniappa. Protein-induced hyperinsulinaemic hypoglycaemia due to a homozygous HADH mutation in three siblings of a Saudi family. Journal of pediatric endocrinology & metabolism : JPEM. vol 28. issue 9-10. 2016-06-17. PMID:25915078. |
hyperinsulinaemic hypoglycaemia (hh) is caused by mutations in the key genes involved in regulation of insulin secretion from the pancreatic β-cells and mutations in abcc8 and kcnj11 are the most common causes of hh. |
2016-06-17 |
2023-08-13 |
Not clear |
| Klára Roženková, Maria Güemes, Pratik Shah, Khalid Hussai. The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia. Journal of clinical research in pediatric endocrinology. vol 7. issue 2. 2016-05-23. PMID:26316429. |
recent advances in genetics have linked chi to mutations in 9 genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a and hnf1a). |
2016-05-23 |
2023-08-13 |
Not clear |
| Carla Pollastro, Carmela Ziviello, Valerio Costa, Alfredo Ciccodicol. Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies? PPAR research. vol 2015. 2015-07-10. PMID:26161088. |
here, we review the relationship between drug responsiveness and polymorphisms in genes involved in drug metabolism (cyp2c9) and insulin signaling (abcc8, kcnj11, and pparg). |
2015-07-10 |
2023-08-13 |
Not clear |
| Suresh Jahnavi, Varadarajan Poovazhagi, Sekar Kanthimathi, Kandasamy Balamurugan, Dhanasekaran Bodhini, Jaivinder Yadav, Vandana Jain, Rajesh Khadgawat, Mahuya Sikdar, Ayurchelvan Bhavatharini, Ashok Kumar Das, Tanvir Kaur, Viswanathan Mohan, Venkatesan Radh. Novel ABCC8 (SUR1) gene mutations in Asian Indian children with congenital hyperinsulinemic hypoglycemia. Annals of human genetics. vol 78. issue 5. 2015-04-08. PMID:25117148. |
congenital hyperinsulinemic hypoglycemia (hi) is a heterogeneous genetic disorder of insulin secretion characterized by persistent hypoglycemia, most commonly associated with inactivating mutations of the β-cell atp-sensitive k(+) channel (k(atp) channel) genes abcc8 (encoding sur1) and kcnj11(encoding kir6.2). |
2015-04-08 |
2023-08-13 |
Not clear |
| Pratik Shah, Huseyin Demirbilek, Khalid Hussai. Persistent hyperinsulinaemic hypoglycaemia in infancy. Seminars in pediatric surgery. vol 23. issue 2. 2015-01-29. PMID:24931352. |
the molecular basis of phhi involves defects in key genes (abcc8, kcnj11, gck, slc16a1, hadh, ucp2, hnf4a and glud1) that regulate insulin secretion. |
2015-01-29 |
2023-08-13 |
Not clear |
| Yanmei Sang, Zidi Xu, Min Liu, Jie Yan, Yujun Wu, Cheng Zhu, Guichen N. Mutational analysis of ABCC8, KCNJ11, GLUD1, HNF4A and GCK genes in 30 Chinese patients with congenital hyperinsulinism. Endocrine journal. vol 61. issue 9. 2015-01-23. PMID:25008049. |
all exons of the adenosine triphosphate (atp)-sensitive potassium channel (katp channel) genes kcnj11 and abcc8, the hepatocyte nuclear factor 4 α (hnf4a) gene, and the glucokinase (gck) gene as well as exons 6 and 7 and 10-12 of the glutamate dehydrogenase 1 (glud1) gene were amplified from genomic dna and directly sequenced. |
2015-01-23 |
2023-08-13 |
human |