| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Jawad Fares, Zeina Bou Diab, Sanaa Nabha, Youssef Fare. Neurogenesis in the adult hippocampus: history, regulation, and prospective roles. The International journal of neuroscience. vol 129. issue 6. 2019-08-12. PMID:30433866. |
abbreviations ahn adult hippocampal neurogenesis akt protein kinase b bmp bone morphogenic protein brdu bromodeoxyuridine cns central nervous system dg dentate gyrus disc1 disrupted-in-schizophrenia 1 fgf-2 fibroblast growth factor 2 gaba gamma-aminobutyric acid mbd1 methyl-cpg-binding domain protein 1 mecp2 methyl-cpg-binding protein 2 mtor mammalian target of rapamycin nscs neural stem cells ob olfactory bulb; p21: cyclin-dependent kinase inhibitor 1 rbpj recombination signal binding protein for immunoglobulin kappa j region rms rostral migratory stream sgz subgranular zone shh sonic hedgehog sox2 sry (sex determining region y)-box 2 svz subventricular zone wnt3 wingless-type mouse mammary tumor virus. |
2019-08-12 |
2023-08-13 |
mouse |
| Kin-Hoe Chow, Dong-Mi Shin, Molly H Jenkins, Emily E Miller, David J Shih, Seungbum Choi, Benjamin E Low, Vivek Philip, Brad Rybinski, Roderick T Bronson, Michael D Taylor, Kyuson Yu. Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. Cancer research. vol 74. issue 17. 2015-03-17. PMID:25136069. |
notably, tics from different subtypes were differentially sensitive to shh or akt pathway inhibitors, highlighting new mechanisms of resistance to targeted therapies. |
2015-03-17 |
2023-08-13 |
mouse |
| Minzhao Huang, Su-Ni Tang, Ghanshyam Upadhyay, Justin L Marsh, Christopher P Jackman, Rakesh K Srivastava, Sharmila Shanka. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. Cancer letters. vol 353. issue 1. 2014-11-04. PMID:25050737. |
taken together, our data show that the rottlerin induces apoptosis and inhibits pancreatic cancer growth by targeting akt, notch and shh signaling pathways, and provide a new therapeutic approach with translational potential for humans. |
2014-11-04 |
2023-08-13 |
mouse |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Boban M Erovic, Dae Kim, Clarissa Cassol, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Prognostic and predictive markers in medullary thyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23150029. |
we therefore examined morphologic features of aggressive behavior and the expression of 41 proteins involved in apoptosis, cell cycle, angiogenesis, inflammation, cell adhesion, tumor-specific markers, and wnt, shh, and akt pathways using tissue microarray from 23 patients with medullary thyroid carcinoma. |
2013-05-23 |
2023-08-12 |
Not clear |