| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xin Li, Yu-Hong Fu, Xue-Wei Tong, Yi-Tong Zhang, Yong-Yan Shan, Yu-Xin Xu, Sheng-Dan Pu, Xin-Yuan Ga. RAAS in diabetic retinopathy: mechanisms and therapies. Archives of endocrinology and metabolism. vol 68. 2024-04-23. PMID:38652701. |
recently, it has been found that the upregulation of the renin-angiotensin-aldosterone system (raas) leads to overexpression of angiotensin ii (ang ii), which induces oxidative stress, inflammation, and angiogenesis in the retina. |
2024-04-23 |
2024-04-26 |
Not clear |
| Jing Li, Xiaochen Wang, Jie Bai, Huangzhao Wei, Wenbo Wang, Shuai Wan. Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. Journal of translational medicine. vol 22. issue 1. 2024-02-15. PMID:38360728. |
to see if sirtuin 1 (sirt1) regulates angiotensin ii (ang ii)-induced hypertensive retinopathy and inflammation by modulating nod-like receptor thermal protein domain associated protein 3 (nlrp3) inflammasome activation and the potential protective effects of fucoidan (fo) in mouse retinal vascular endothelial cells (mrecs) and mice retina. |
2024-02-15 |
2024-02-18 |
mouse |
| He Chen, Xin-Yu Zhao, You-Xin Chen, Ting-Ting Den. Angiotensin II is a crucial factor in retinal aneurysm formation. Experimental eye research. vol 213. 2021-12-08. PMID:34757002. |
we found that ang ii infusion induced aneurysm formation in mice retina, which presented as either solitary aneurysms or retinal arterial beading. |
2021-12-08 |
2023-08-13 |
mouse |
| Natarajan Perumal, Lars Straßburger, David P Herzog, Marianne B Müller, Norbert Pfeiffer, Franz H Grus, Caroline Manica. Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery. Redox biology. vol 34. 2021-06-18. PMID:32513477. |
here, we provide the first direct evidence of the alterations of proteome and signalling pathways underlying ang ii-elicited oxidative insult independent of arterial pressure changes in the ophthalmic artery (oa) and retina (r) employing an in vitro experimental model. |
2021-06-18 |
2023-08-13 |
mouse |
| Indrajeetsinh Rana, Varaporn Suphapimol, Jack R Jerome, Dean M Talia, Devy Deliyanti, Jennifer L Wilkinson-Berk. Angiotensin II and aldosterone activate retinal microglia. Experimental eye research. vol 191. 2020-07-24. PMID:31884019. |
two animal models were studied that featured up-regulation of ang ii or aldosterone and included transgenic ren-2 rats which overexpress renin and ang ii in tissues including the retina, and sprague dawley rats with ischemic retinopathy and infused with aldosterone. |
2020-07-24 |
2023-08-13 |
rat |
| Indrajeetsinh Rana, Varaporn Suphapimol, Jack R Jerome, Dean M Talia, Devy Deliyanti, Jennifer L Wilkinson-Berk. Angiotensin II and aldosterone activate retinal microglia. Experimental eye research. vol 191. 2020-07-24. PMID:31884019. |
we hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin ii (ang ii) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ros) as well as pro-angiogenic and pro-inflammatory factors. |
2020-07-24 |
2023-08-13 |
rat |
| Joanna A Phipps, Michael A Dixon, Andrew I Jobling, Anna Y Wang, Ursula Greferath, Kirstan A Vessey, Erica L Fletche. The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease. Experimental eye research. vol 187. 2020-02-28. PMID:31408629. |
as components of the ras are located on the principal neurons, glia and blood vessels of the retina, it is possible that ang ii has a role in regulating communication and function between these three cell types, and therefore the capacity to regulate neurovascular coupling. |
2020-02-28 |
2023-08-13 |
Not clear |
| Germán Domínguez-Vías, Garbiñe Aretxaga-Maza, Isabel Prieto, Juan de Dios Luna, Marc De Gasparo, Manuel Ramírez-Sánche. Diurnal opposite variation between angiotensinase activities in photo-neuro-endocrine tissues of rats. Chronobiology international. vol 34. issue 9. 2018-08-07. PMID:28910547. |
in the present study, we analysed the aspartyl- (aspap) and glutamyl-aminopeptidase (gluap) (aminopeptidase a) activities, the angiotensinases responsible for the metabolism of ang i to ang 2-10 and ang ii to ang iii, respectively, in the retina, anterior hypothalamus and pituitary at different light and dark time-points of a 12:12 h light:dark cycle (7-19 h light), using arylamide derivatives as substrates. |
2018-08-07 |
2023-08-13 |
rat |
| Mohammad Shamsul Ola, Abdullah S Alhomida, Carlos M Ferrario, Sarfaraz Ahma. Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Current medicinal chemistry. vol 24. issue 28. 2017-12-05. PMID:28403787. |
thus, a better understanding of ang ii formation pathways in the diabetic retina will elucidate early molecular mechanism of vision loss. |
2017-12-05 |
2023-08-13 |
human |
| Mohammad Shamsul Ola, Abdullah S Alhomida, Carlos M Ferrario, Sarfaraz Ahma. Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Current medicinal chemistry. vol 24. issue 28. 2017-12-05. PMID:28403787. |
angiotensin ii (ang ii), an active component of the ras is increased in diabetic retina, and may play a significant role in neurovascular damage leading to the progression of dr. |
2017-12-05 |
2023-08-13 |
human |
| Zhenhao Lin, Yunjie Ni, Lianglei Hou, Lijuan Song, Yihao Wu, Huanhuan Hu, Juhong Zhang, Deye Yan. [Telmisartan reduces retina vessel endothelial cell apoptosis via upregulating retinal ACE2-Ang-(1-7)-Mas axis in spontaneous hypertensive rats]. Zhonghua xin xue guan bing za zhi. vol 43. issue 7. 2016-07-06. PMID:26420325. |
to investigate the effects of angiotensin ii (ang ii) antagonist telmisartan on retina vessel endothelial cell apoptosis and its impact on the ace2-ang-(1-7)-mas axis in spontaneous hypertensive rats (shr). |
2016-07-06 |
2023-08-13 |
rat |
| Tuhina Prasad, Amrisha Verma, Qiuhong L. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. Molecular vision. vol 20. 2015-06-26. PMID:25352750. |
we have recently shown that increased expression of ace2 and angiotensin (1-7) [ang (1-7)], two components of the protective axis of the ras, in the retina via adeno-associated virus (aav)-mediated gene delivery, conferred protection against diabetes-induced retinopathy. |
2015-06-26 |
2023-08-13 |
mouse |
| Antonia G Miller, Genevieve Tan, Katrina J Binger, Raelene J Pickering, Merlin C Thomas, Ram H Nagaraj, Mark E Cooper, Jennifer L Wilkinson-Berk. Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function. Diabetes. vol 59. issue 12. 2010-12-30. PMID:20852029. |
we hypothesized that, in retina, angiotensin ii (ang ii) downregulates glo-i, which leads to an increase in methylglyoxal-age formation. |
2010-12-30 |
2023-08-12 |
Not clear |
| Vladimir M Milenkovic, Marisa Brockmann, Christian Meyer, Michael Desch, Frank Schweda, Armin Kurtz, Vladimir Todorov, Olaf Straus. Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli. American journal of physiology. Renal physiology. vol 299. issue 2. 2010-09-03. PMID:20519377. |
in sections of the mouse retina, the ang ii receptor at(1) was found in the rpe and localized at the blood side of the epithelium. |
2010-09-03 |
2023-08-12 |
mouse |
| Vladimir M Milenkovic, Marisa Brockmann, Christian Meyer, Michael Desch, Frank Schweda, Armin Kurtz, Vladimir Todorov, Olaf Straus. Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli. American journal of physiology. Renal physiology. vol 299. issue 2. 2010-09-03. PMID:20519377. |
systemic infusion of ang ii led to a decrease in the renin expression in the kidney and in the retina and rpe. |
2010-09-03 |
2023-08-12 |
mouse |
| L E Downie, K Vessey, A Miller, M M Ward, M J Pianta, A J Vingrys, J L Wilkinson-Berka, E L Fletche. Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina. Neuroscience. vol 161. issue 1. 2009-09-21. PMID:19298848. |
the differential pattern of expression of these receptors across these cell types is similar to that observed in the brain and suggests that a similar functional role for ang ii may also exist within the retina. |
2009-09-21 |
2023-08-12 |
rat |
| Jeong Hun Kim, Jin Hyoung Kim, Young Suk Yu, Chang Sik Cho, Kyu-Won Ki. Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 3. 2009-03-23. PMID:19107135. |
moreover, inhibition of ang ii by perindopril attenuated increased vascular permeability of diabetic retina accompanied by recovery of tight junction proteins in retinal vessels. |
2009-03-23 |
2023-08-12 |
Not clear |
| Joanna A Phipps, Allen C Clermont, Sukanto Sinha, Tamie J Chilcote, Sven-Erik Bursell, Edward P Feene. Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability. Hypertension (Dallas, Tex. : 1979). vol 53. issue 2. 2009-02-13. PMID:19124682. |
we found that plasma kallikrein levels are increased in the retina of rats with ang ii-stimulated hypertension and that intravitreal injection of either plasma kallikrein or bradykinin is sufficient to increase rvp. |
2009-02-13 |
2023-08-12 |
rat |
| Ping Chen, Austin M Guo, Paul A Edwards, Gary Trick, A Guillermo Scicl. Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 4. 2007-11-27. PMID:17652361. |
in addition, incubation of dihydroethidium-loaded retina sections with ang ii caused marked increase in superoxide formation. |
2007-11-27 |
2023-08-12 |
rat |
| Preenie deS Senanayake, Judy Drazba, Karen Shadrach, Amy Milsted, Elisabeth Rungger-Brandle, Kazutoshi Nishiyama, Shin-Ichiro Miura, Sadashiva Karnik, Jonathan E Sears, Joe G Hollyfiel. Angiotensin II and its receptor subtypes in the human retina. Investigative ophthalmology & visual science. vol 48. issue 7. 2007-08-23. PMID:17591902. |
to quantify and evaluate the distribution of angiotensin ii (ang ii) and its receptors in the human retina. |
2007-08-23 |
2023-08-12 |
human |