| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias Przyklenk, Shreya Karmacharya, Debora Bonasera, Arthur-Lauri Pasanen-Zentz, Stanislav Kmoch, Mats Paulsson, Raimund Wagener, Gianmaria Liccardi, Alvise Schiavinat. ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder. Scientific reports. vol 14. issue 1. 2024-04-24. PMID:38653789. |
we provide novel insights into antxr1's physiological functions and propose gapo syndrome to be reconsidered as a progeroid disorder highlighting an unexpected role for an integrin-like extracellular matrix receptor in human aging. |
2024-04-24 |
2024-04-26 |
human |
| Fan Feng, Bo Cheng, Baixiang Cheng, Yuanbo Jia, Min Zhang, Feng X. ANTXR1 as a Potential Sensor of Extracellular Mechanical Cues. Acta biomaterialia. 2023-01-13. PMID:36638946. |
emerging evidence indicates that anthrax toxin receptor 1 (antxr1), a newly identified cell adhesion molecule, can also sense extracellular mechanical signals such as hydrostatic pressure and extracellular matrix (ecm) rigidity. |
2023-01-13 |
2023-08-14 |
Not clear |
| Mohamed S Abdel-Hamid, Samira Ismail, Maha S Zaki, Ghada M H Abdel-Salam, Ghada A Otaify, Mahmoud Y Issa, Mohamed Abdel-Kader, Marian Girgis, Eman Aboul-Ezz, Inas Mazen, Mona S Aglan, Samia A Temtam. GAPO syndrome in seven new patients: Identification of five novel ANTXR1 mutations including the first large intragenic deletion. American journal of medical genetics. Part A. vol 179. issue 2. 2020-02-06. PMID:30575274. |
our results reinforce the clinical characteristics of the syndrome, expand the mutational spectrum and provide more insights into the role of the antxr1 protein in the regulation of extracellular matrix. |
2020-02-06 |
2023-08-13 |
Not clear |
| Jong Min Baek, Sung Chul Kwak, Kwon-Ha Yoon, Ju-Young Kim, Myeung Su Le. Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function. Biochemical and biophysical research communications. vol 510. issue 2. 2019-11-12. PMID:30686531. |
in addition, genetic manipulation of antxr1 in bone marrow macrophages (bmms) modulated the capillary-like tube formation in huvecs via secretion of two angiogenic factors, matrix metalloproteinase-9 (mmp-9) and vascular endothelial growth factor-a (vegf-a). |
2019-11-12 |
2023-08-13 |
Not clear |
| Jason M Knight, Eunji Kim, Ivan Ivanov, Laurie A Davidson, Jennifer S Goldsby, Meredith A J Hullar, Timothy W Randolph, Andrew M Kaz, Lisa Levy, Johanna W Lampe, Robert S Chapki. Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Physiological genomics. vol 48. issue 9. 2018-01-25. PMID:27401218. |
for example, consistent with a key role of stroma in the crypt niche, mrnas associated with immunoregulatory and inflammatory processes (i.e., cxcl14, antxr1), smooth muscle contraction (cald1), proliferation and apoptosis (glp2r, igfbp3), and modulation of extracellular matrix (mmp2, col3a1, mfap4) were all highly expressed in the stroma. |
2018-01-25 |
2023-08-13 |
human |
| Bjorn R Olsen, Agnes D Berendsen, Tatiana Y Besschetnova, Xuchen Duan, Kai H. Fell-Muir Lecture: Regulatory mechanisms of skeletal and connective tissue development and homeostasis - lessons from studies of human disorders. International journal of experimental pathology. vol 97. issue 4. 2017-07-17. PMID:27581728. |
through controlling vegf-a signalling and extracellular matrix synthesis, antxr1 is emerging as a key regulator of skeletal and connective tissue development and homeostasis. |
2017-07-17 |
2023-08-13 |
mouse |
| Tatiana Y Besschetnova, Takaharu Ichimura, Negin Katebi, Brad St Croix, Joseph V Bonventre, Bjorn R Olse. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix biology : journal of the International Society for Matrix Biology. vol 42. 2016-01-14. PMID:25572963. |
we demonstrate here that the matrix receptor anthrax toxin receptor 1 (antxr1), also known as tumor endothelial marker 8 (tem8), is an essential component of these mechanisms. |
2016-01-14 |
2023-08-13 |
mouse |
| Yavuz Bayram, Davut Pehlivan, Ender Karaca, Tomasz Gambin, Shalini N Jhangiani, Serkan Erdin, Claudia Gonzaga-Jauregui, Wojciech Wiszniewski, Donna Muzny, Nursel H Elcioglu, M Selman Yildirim, Banu Bozkurt, Ayse Gul Zamani, Eric Boerwinkle, Richard A Gibbs, James R Lupsk. Whole exome sequencing identifies three novel mutations in ANTXR1 in families with GAPO syndrome. American journal of medical genetics. Part A. vol 164A. issue 9. 2015-04-20. PMID:25045128. |
our studies expand the allelic spectrum in this rare condition and potentially provide insight into the role of antxr1 in the regulation of the extracellular matrix. |
2015-04-20 |
2023-08-13 |
Not clear |