| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Kangkan Sarma, Md Habban Akther, Irfan Ahmad, Obaid Afzal, Abdulmalik S A Altamimi, Manal A Alossaimi, Mariusz Jaremko, Abdul-Hamid Emwas, Preety Gauta. Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474590. |
stroma, hypoxia, ph, and immunity-modulating agents conjugated or modified nanocarriers co-administered with pathway-blocking or condition-modulating agents can regulate extracellular matrix (ecm), cancer-associated fibroblasts (caf),tyro3, axl, and mertk receptors (tam) regulation, regulatory t-cell (treg) inhibition, and myeloid-derived suppressor cells (mdsc) inhibition. |
2024-03-13 |
2024-03-15 |
Not clear |
| Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Che. Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression. Transplantation. 2022-05-12. PMID:35546091. |
axl is a member of the tyro3, axl, mertk family and is involved in immune and apoptosis processes in multiple organs. |
2022-05-12 |
2023-08-13 |
Not clear |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Juwen C DuBois, Alex K Ray, Peter Davies, Bridget Shafit-Zagard. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33121494. |
during experimental autoimmune encephalomyelitis (eae), the mrna expression of mertk, gas6, and axl significantly increase, whereas tyro3 and pros1 remain unchanged. |
2021-09-16 |
2023-08-13 |
Not clear |
| Jianfeng Zhuang, Yucong Peng, Chi Gu, Huihui Chen, Zheng Lin, Hang Zhou, Xiao Wu, Jianru Li, Xiaobo Yu, Yang Cao, Hanhai Zeng, Xiongjie Fu, Chaoran Xu, Peiyu Huang, Shenglong Cao, Chun Wang, Feng Yan, Gao Che. Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage. Translational stroke research. vol 12. issue 4. 2021-07-23. PMID:32918259. |
wogonin promoted hematoma clearance and improved neurological recovery after ich by upregulating the expression of axl, mertk, cd36, and lamp2 in perihematomal microglia and bv2 cells. |
2021-07-23 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Candace M Marsters, Faizan Malik, Rena Far, Lata Adnani, Carol Schuurmans, Quentin J Pittman, Deborah M Kurrasc. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell reports. vol 34. issue 1. 2021-06-18. PMID:33406432. |
embryonic microglia interact with hypothalamic radial glia during development and upregulate the tam receptors mertk and axl following an insult. |
2021-06-18 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Candace M Marsters, Faizan Malik, Rena Far, Lata Adnani, Carol Schuurmans, Quentin J Pittman, Deborah M Kurrasc. Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell reports. vol 34. issue 1. 2021-06-18. PMID:33406432. |
mechanistically, the tam receptors mertk and axl were upregulated in microglia following the insult, and annexin v treatment inhibited radial glia breakage and engulfment by microglia. |
2021-06-18 |
2023-08-13 |
Not clear |
| Qian Jiang, Christopher R Stone, Kenneth Elkin, Xiaokun Geng, Yuchuan Din. Immunosuppression and Neuroinflammation in Stroke Pathobiology. Experimental neurobiology. vol 30. issue 2. 2021-05-25. PMID:33972464. |
the release of danger-/damage-associated molecular patterns (damps) activates toll-like receptors (tlrs), contributing to the harmful inflammatory effects of ischemia/reperfusion injury after stroke; the tyro3, axl, and mertk (tam)/gas6 system, however, has been shown to suppress inflammation via downstream signaling molecules that inhibit tlr signaling. |
2021-05-25 |
2023-08-13 |
Not clear |
| Zaofeng Zou, Jingxian Sun, Zheng Kang, Yumeng Wang, Hui Zhao, Keying Zhu, Jun Wan. Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32714402. |
it has been revealed that tam receptor tyrosine kinases (tyro3, axl, and mertk) play pivotal roles in regulating multiple features of microglia, including the phagocytic function and myelin clearance. |
2020-09-28 |
2023-08-13 |
mouse |
| Rainer Akkermann, Andrea Aprico, Ashwyn A Perera, Helena Bujalka, Alistair E Cole, Junhua Xiao, Judith Field, Trevor J Kilpatrick, Michele D Binde. The TAM receptor Tyro3 regulates myelination in the central nervous system. Glia. vol 65. issue 4. 2018-01-12. PMID:28145605. |
we have previously identified that the protein gas6, a ligand for a family of tyrosine kinase receptors known as the tam (tyro3, axl, and mertk) receptors, directly increases oligodendrocyte induced myelination in vitro. |
2018-01-12 |
2023-08-13 |
Not clear |
| Jonathan J Miner, Brian P Daniels, Bimmi Shrestha, Jose L Proenca-Modena, Erin D Lew, Helen M Lazear, Matthew J Gorman, Greg Lemke, Robyn S Klein, Michael S Diamon. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nature medicine. vol 21. issue 12. 2016-05-13. PMID:26523970. |
unexpectedly, mice lacking mertk and/or axl, but not tyro3, exhibited greater vulnerability to infection with neuroinvasive west nile and la crosse encephalitis viruses. |
2016-05-13 |
2023-08-13 |
mouse |
| Ross C Gruber, Alex K Ray, Christopher T Johndrow, Hillary Guzik, Dominika Burek, Pablo García de Frutos, Bridget Shafit-Zagard. Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471571. |
during experimental autoimmune encephalomyelitis (eae), wild-type (wt) mice demonstrate a significant induction of gas6, axl, and mertk but not pros1 or tyro3 mrna. |
2015-02-19 |
2023-08-13 |
mouse |
| Rui Ji, Shifu Tian, Helen J Lu, Qingjun Lu, Yan Zheng, Xiaomin Wang, Jixiang Ding, Qiutang Li, Qingxian L. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. Journal of immunology (Baltimore, Md. : 1950). vol 191. issue 12. 2014-02-18. PMID:24244024. |
il-6 knockout in axl(-/-)mertk(-/-) double-knockout mice overcomes the inflammatory inhibition of neurogenesis, suggesting that il-6 is a major downstream neurotoxic mediator under homeostatic regulation by tam receptors in microglia. |
2014-02-18 |
2023-08-12 |
mouse |
| Fei Ye, Lixia Han, Qingjun Lu, Wanwei Dong, Zhenwen Chen, Hui Shao, Henry J Kaplan, Qiutang Li, Qingxian L. Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 8. 2011-11-15. PMID:21918185. |
the tam family of receptors (tyro3, axl, and mertk) plays an important role in the negative regulation of response of dendritic cells (dcs) and macrophages to pathogenic stimuli, and mice lacking this receptor family develop spontaneous lupus-like systemic autoimmunity against a variety of tissues, including retina. |
2011-11-15 |
2023-08-12 |
mouse |
| Michele D Binder, Junhua Xiao, Dennis Kemper, Gerry Z M Ma, Simon S Murray, Trevor J Kilpatric. Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination. PloS one. vol 6. issue 3. 2011-07-05. PMID:21423702. |
we have identified a family of receptor protein tyrosine kinases, known as the tam receptors (tyro3, axl and mertk), as potentially important in regulating both the oligodendrocyte and immune responses. |
2011-07-05 |
2023-08-12 |
mouse |
| Heather M Seitz, Todd D Camenisch, Greg Lemke, H Shelton Earp, Glenn K Matsushim. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 9. 2007-06-18. PMID:17442946. |
thus, cell and organ type specificity is clearly delineated, with dcs relying on axl and tyro3, retina and thymus requiring mertk, and macrophages exhibiting an interaction that involves all three family members. |
2007-06-18 |
2023-08-12 |
mouse |