| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinghua Gui, Tamsin J Samuels, Katarina Z A Grobicki, Felipe Karam Teixeir. Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation. Cell reports. vol 42. issue 3. 2023-03-04. PMID:36870055. |
using the drosophila adult female germline stem cell and larval neuroblast systems, we show that mei-p26 and brat, two drosophila trim-nhl paralogs, are responsible for uncoupling ribi and protein synthesis during differentiation. |
2023-03-04 |
2023-08-14 |
drosophila_melanogaster |
| Elizabeth D Larson, Hideyuki Komori, Zoe A Fitzpatrick, Samuel D Krabbenhoft, Cheng-Yu Lee, Melissa Harriso. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. G3 (Bethesda, Md.). 2022-07-25. PMID:35876878. |
brat also regulates zelda levels in the larval neuroblast lineage. |
2022-07-25 |
2023-08-14 |
drosophila_melanogaster |
| Hideyuki Komori, Qi Xiao, Brooke M McCartney, Cheng-Yu Le. Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development (Cambridge, England). vol 141. issue 1. 2014-03-11. PMID:24257623. |
by contrast, reducing arm activity in immature inps suppresses supernumerary neuroblast formation in brat mutant brains. |
2014-03-11 |
2023-08-12 |
drosophila_melanogaster |
| Hideyuki Komori, Qi Xiao, Brooke M McCartney, Cheng-Yu Le. Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development (Cambridge, England). vol 141. issue 1. 2014-03-11. PMID:24257623. |
during asymmetric division of a type ii neural stem cell (neuroblast) in the drosophila larval brain, the brain tumor (brat) protein segregates unequally into the immature intermediate neural progenitor (inp), where it specifies inp identity by attenuating the function of the self-renewal factor klumpfuss (klu), but the mechanisms are not understood. |
2014-03-11 |
2023-08-12 |
drosophila_melanogaster |
| Hideyuki Komori, Qi Xiao, Brooke M McCartney, Cheng-Yu Le. Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development (Cambridge, England). vol 141. issue 1. 2014-03-11. PMID:24257623. |
aberrantly increasing arm activity in immature inps further exacerbates the defects in the specification of inp identity and enhances the supernumerary neuroblast mutant phenotype in brat mutant brains. |
2014-03-11 |
2023-08-12 |
drosophila_melanogaster |
| Heinrich Reicher. Drosophila neural stem cells: cell cycle control of self-renewal, differentiation, and termination in brain development. Results and problems in cell differentiation. vol 53. 2011-08-25. PMID:21630158. |
neuroblasts in the developing fly brain generate neurons through repeated series of asymmetrical cell divisions, which balance self-renewal of the neuroblast with generation of differentiated progeny through the segregation of cell fate determinants such as numb, prospero, and brat to the neural progeny. |
2011-08-25 |
2023-08-12 |
drosophila_melanogaster |
| Sarah K Bowman, Vivien Rolland, Joerg Betschinger, Kaolin A Kinsey, Gregory Emery, Juergen A Knoblic. The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Developmental cell. vol 14. issue 4. 2008-05-19. PMID:18342578. |
the tumor suppressors brat and numb regulate transit-amplifying neuroblast lineages in drosophila. |
2008-05-19 |
2023-08-12 |
drosophila_melanogaster |
| Cheng-Yu Lee, Brian D Wilkinson, Sarah E Siegrist, Robin P Wharton, Chris Q Do. Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Developmental cell. vol 10. issue 4. 2006-05-16. PMID:16549393. |
in brat mutants, another miranda cargo protein (prospero) is not partitioned into gmcs, gmcs fail to downregulate neuroblast gene expression, and there is a massive increase in neuroblast numbers. |
2006-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Cheng-Yu Lee, Brian D Wilkinson, Sarah E Siegrist, Robin P Wharton, Chris Q Do. Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Developmental cell. vol 10. issue 4. 2006-05-16. PMID:16549393. |
brat is a miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. |
2006-05-16 |
2023-08-12 |
drosophila_melanogaster |
| Cheng-Yu Lee, Brian D Wilkinson, Sarah E Siegrist, Robin P Wharton, Chris Q Do. Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Developmental cell. vol 10. issue 4. 2006-05-16. PMID:16549393. |
we conclude that brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation. |
2006-05-16 |
2023-08-12 |
drosophila_melanogaster |