All Relations between cox1 and Nicotine
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Jinghao Yang, Shuo Li, Yao Jiang, Jiaqi Li, Xiaolong Yua. Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals. Ecotoxicology and environmental safety. vol 277. 2024-04-23. PMID:38653025. | moreover, prostaglandin e2 (pge2) inhibited the apoptosis of gcs and facilitated follicular maturation, and nicotine appeared to inhibit pge2 secretion by freezing the expression of cyclooxygenase 1 (cox1), which was the rate-limiting and essential enzyme for pge2 synthesis. | 2024-04-23 | 2024-04-26 | Not clear |
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Jinghao Yang, Shuo Li, Yao Jiang, Jiaqi Li, Xiaolong Yua. Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals. Ecotoxicology and environmental safety. vol 277. 2024-04-23. PMID:38653025. | epigenetically, the nicotine was observed to diminish the histone h3 lysine 9 acetylation (h3k9ac) level and compact the chromatin accessibility in -1776/-1499 bp region of cox1 by evoking the expression of hdac3, with the deactivated cas9-hdac3/sgrna system. | 2024-04-23 | 2024-04-26 | Not clear |