| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cláudio Rodrigues Rezende Costa, Rym Chalgoumi, Amina Baker, Clément Guillou, Paulo Marcio Yamaguti, Victor Simancas Escorcia, Lilia Abbad, Bruna Rabelo Amorin, Caroline Lourenço de Lima, Vidjea Cannaya, Mourad Benassarou, Ariane Berdal, Christos Chatziantoniou, Olivier Cases, Pascal Cosette, Renata Kozyraki, Ana Carolina Aceved. Gingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis. Scientific reports. vol 14. issue 1. 2024-04-25. PMID:38664418. |
rns is caused by loss-of-function disease-causative variants of the fam20c gene that encodes a kinase that phosphorylates most of the secreted proteins found in the body fluids and extracellular matrix. |
2024-04-25 |
2024-04-28 |
Not clear |
| Qing-Qing Li, Meng Guo, Guang-Huan He, Kai-Hua Xi, Mei-Yi Zhou, Rong-Yi Shi, Guo-Qiang Che. VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane. Oncogene. 2024-04-23. PMID:38654108. |
reciprocally, deficiency of nrdp1 in vecs (ecnrdp1) results in increased secretion of fam20c, which induces degradation of extracellular matrix and disrupts integrity of vascular basement membrane, thus driving tumor metastatic dissemination. |
2024-04-23 |
2024-04-26 |
mouse |
| Changchun Dong, Bikash Lamichhane, Hajime Yamazaki, Brent Vasquez, Jingya Wang, Yongxu Zhang, Jian Q Feng, Henry C Margolis, Elia Beniash, Xiaofang Wan. The phosphorylation of serine Matrix biology : journal of the International Society for Matrix Biology. 2022-07-12. PMID:35820561. |
as one of the major enamel matrix proteins (emps), enamelin (enam) has three serines located in ser-x-glu (s-x-e) motifs, which are potential phosphorylation sites for the golgi casein kinase fam20c. |
2022-07-12 |
2023-08-14 |
Not clear |
| Maria Dzamukova, Tobias M Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L Vincent, Max Löhnin. Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth. Nature communications. vol 13. issue 1. 2022-06-01. PMID:35650194. |
fam20c, the major kinase of the secreted phosphoproteome, phosphorylates dentin matrix protein 1, previously identified as a key factor in bone mineralization. |
2022-06-01 |
2023-08-13 |
Not clear |
| Jing Feng, Jinping Zhou, Lin Zhao, Xinpeng Wang, Danyu Ma, Baoqing Xu, Feilai Xie, Xingfeng Qi, Gang Chen, Hu Zhao, Junxin W. Fam20C Overexpression Predicts Poor Outcomes and is a Diagnostic Biomarker in Lower-Grade Glioma. Frontiers in genetics. vol 12. 2021-12-31. PMID:34970298. |
gene set enrichment analysis also revealed the potential signaling pathways associated with fam20c gene expression in lgg; these pathways were mainly enriched in extracellular matrix receptor interactions, cell adhesion, cell apoptosis, notch signaling, cell cycle, etc. |
2021-12-31 |
2023-08-13 |
Not clear |
| Ju-Hsien Lin, I-Ping Lin, Yoshio Ohyama, Hanna Mochida, Akira Kudo, Masaru Kaku, Yoshiyuki Mochid. FAM20C directly binds to and phosphorylates Periostin. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:33051588. |
immunolocalization of fam20c was observed in periodontal ligament (pdl) extracellular matrix where that of periostin was also immunostained in murine periodontal tissues. |
2021-01-13 |
2023-08-13 |
mouse |
| Ju-Hsien Lin, I-Ping Lin, Yoshio Ohyama, Hanna Mochida, Akira Kudo, Masaru Kaku, Yoshiyuki Mochid. FAM20C directly binds to and phosphorylates Periostin. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:33051588. |
however, there has been no report that any extracellular matrix molecules expressed in periodontal tissues are indeed substrates of fam20c. |
2021-01-13 |
2023-08-13 |
mouse |
| Michael P Whyte, William H McAlister, Michael D Fallon, Mary Ella Pierpont, Vinieth N Bijanki, Shenghui Duan, Ghada A Otaify, William S Sly, Steven Mum. Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 32. issue 4. 2017-07-28. PMID:27862258. |
in 2007, the etiology emerged as loss-of-function mutation of fam20c that encodes family with sequence similarity 20, member c. fam20c is highly expressed in embryonic calcified tissues and encodes a kinase (dentin matrix protein 4) for most of the secreted phosphoproteome including fgf23, osteopontin, and other regulators of skeletal mineralization. |
2017-07-28 |
2023-08-13 |
Not clear |
| Giorgio Cozza, Mauro Salvi, Vincent S Tagliabracci, Lorenzo A Pinn. Fam20C is under the control of sphingolipid signaling in human cell lines. The FEBS journal. vol 284. issue 8. 2017-05-23. PMID:28236661. |
fam20c, also termed dmp-4 (dentin matrix protein 4) and g-ck (golgi casein kinase) is an atypical protein kinase committed with the phosphorylation of casein and a plethora of other secreted proteins. |
2017-05-23 |
2023-08-13 |
human |
| P Ma, W Yan, Y Tian, J He, S J Brookes, X Wan. The Importance of Serine Phosphorylation of Ameloblastin on Enamel Formation. Journal of dental research. vol 95. issue 12. 2017-05-17. PMID:27470066. |
fam20c is a newly identified kinase on the secretory pathway responsible for the phosphorylation of serine residues in the ser-x-glu/pser motifs in several enamel matrix proteins. |
2017-05-17 |
2023-08-13 |
mouse |
| Kaori Oya, Ken Ishida, Tomoki Nishida, Sunao Sato, Mitsunobu Kishino, Katsutoshi Hirose, Yuzo Ogawa, Kazunori Ikebe, Fumio Takeshige, Hidehiro Yasuda, Toshihisa Komori, Satoru Toyosaw. Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization. Histochemistry and cell biology. vol 147. issue 3. 2017-04-25. PMID:27614627. |
immunohistochemical analysis of dentin matrix protein 1 (dmp1) phosphorylation by fam20c in bone: implications for the induction of biomineralization. |
2017-04-25 |
2023-08-13 |
rat |
| Jixin Cui, Junyu Xiao, Vincent S Tagliabracci, Jianzhong Wen, Meghdad Rahdar, Jack E Dixo. A secretory kinase complex regulates extracellular protein phosphorylation. eLife. vol 4. 2016-01-14. PMID:25789606. |
here we show that fam20a potentiates fam20c kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro and in cells. |
2016-01-14 |
2023-08-13 |
Not clear |
| Vincent S Tagliabracci, Sandra E Wiley, Xiao Guo, Lisa N Kinch, Eric Durrant, Jianzhong Wen, Junyu Xiao, Jixin Cui, Kim B Nguyen, James L Engel, Joshua J Coon, Nick Grishin, Lorenzo A Pinna, David J Pagliarini, Jack E Dixo. A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. vol 161. issue 7. 2015-08-31. PMID:26091039. |
fam20c is a kinase that phosphorylates s-x-e/ps motifs on proteins in milk and in the extracellular matrix of bones and teeth. |
2015-08-31 |
2023-08-13 |
human |
| Yuka Kinoshita, Michiko Hori, Manabu Taguchi, Seiji Fukumot. Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia. Bone. vol 67. 2015-05-12. PMID:25026495. |
we analyzed 6 mutant fam20c proteins (t268m, p328s, r408w, d451n, d478a, and r549w) for their distributions, kinase activities, and effects on dentin matrix protein (dmp1) promoter activity. |
2015-05-12 |
2023-08-13 |
mouse |
| Xiaofang Wang, Jingya Wang, Baozhi Yuan, Yongbo Lu, Jian Q Feng, Chunlin Qi. Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connective tissue research. vol 55. issue 4. 2015-02-20. PMID:24874551. |
fam20c is a kinase phosphorylating the small-integrin-binding ligand, n-linked glycoproteins (siblings), a group of extracellular matrix proteins that are essential for bone and dentin formation. |
2015-02-20 |
2023-08-13 |
mouse |
| Andrea Venerando, Maria Ruzzene, Lorenzo A Pinn. Casein kinase: the triple meaning of a misnomer. The Biochemical journal. vol 460. issue 2. 2014-07-06. PMID:24825444. |
these fall into three main classes: two of them, later renamed as protein kinases ck1 (casein kinase 1, also known as cki) and ck2 (also known as ckii), are pleiotropic members of the kinome functionally unrelated to casein, whereas g-ck, or genuine casein kinase, responsible for the phosphorylation of casein in the golgi apparatus of the lactating mammary gland, has only been identified recently with fam20c [family with sequence similarity 20c; also known as dmp-4 (dentin matrix protein-4)], a member of the four-jointed family of atypical protein kinases, being responsible for the phosphorylation of many secreted proteins. |
2014-07-06 |
2023-08-13 |
human |
| Shih-Kai Wang, Andrew C Samann, Jan C-C Hu, James P Simme. FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 28. issue 12. 2014-06-25. PMID:23703840. |
western blots detected fam20c in the eoe extracts but not in the enamel matrix. |
2014-06-25 |
2023-08-12 |
mouse |
| Shih-Kai Wang, Andrew C Samann, Jan C-C Hu, James P Simme. FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 28. issue 12. 2014-06-25. PMID:23703840. |
to see if such mechanisms are possible in the formation of dental enamel, we tested the hypothesis that fam20c is secreted by ameloblasts and accumulates in the enamel extracellular matrix during tooth development. |
2014-06-25 |
2023-08-12 |
mouse |
| Shih-Kai Wang, Andrew C Samann, Jan C-C Hu, James P Simme. FAM20C functions intracellularly within both ameloblasts and odontoblasts in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 28. issue 12. 2014-06-25. PMID:23703840. |
we conclude that fam20c is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts. |
2014-06-25 |
2023-08-12 |
mouse |
| Melanie Fradin, C Stoetzel, J Muller, M Koob, D Christmann, C Debry, M Kohler, M Isnard, D Astruc, P Desprez, C Zorres, E Flori, H Dollfus, B Dora. Osteosclerotic bone dysplasia in siblings with a Fam20C mutation. Clinical genetics. vol 80. issue 2. 2011-11-08. PMID:20825432. |
fam20c codes for the human homolog of dmp4, a dentin matrix protein highly expressed in odontoblasts and moderately in bone. |
2011-11-08 |
2023-08-12 |
human |