| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Li. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection. Signal transduction and targeted therapy. vol 9. issue 1. 2024-04-24. PMID:38654010. |
in the current study, we utilized islet organoids derived from human embryonic stem cells (hescs), animal models and covid-19 patients to discover that fibroblast growth factor 7 (fgf7) enhances ace2 expression within the islets, facilitating sars-cov-2 infection and resulting in impaired insulin secretion. |
2024-04-24 |
2024-04-26 |
human |
| Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Li. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection. Signal transduction and targeted therapy. vol 9. issue 1. 2024-04-24. PMID:38654010. |
finally, animal experiments indicated that sars-cov-2 infection increased pancreatic fgf7 levels, resulting in a reduction of insulin concentrations in situ. |
2024-04-24 |
2024-04-26 |
human |
| R Sekiguchi, M M Mehlferber, K Matsumoto, S Wan. Efficient Gene Knockout in Salivary Gland Epithelial Explant Cultures. Journal of dental research. 2022-11-11. PMID:36366748. |
we further show that salivary epithelial explants can grow and branch with fgf7 alone, while supplementing with insulin, transferrin, and selenium (its) enhances growth and branching. |
2022-11-11 |
2023-08-14 |
mouse |
| Yukihiro Seiji, Takaaki Ito, Yasuko Nakamura, Yuko Nakaishi-Fukuchi, Akira Matsuo, Naruki Sato, Hiroyuki Nogaw. Alveolus-like organoid from isolated tip epithelium of embryonic mouse lung. Human cell. vol 32. issue 2. 2019-04-26. PMID:30635859. |
the lung-tip epithelium isolated using dispase treatment was embedded in low-growth factor matrigel, cultured in dmem/f12 medium containing 0.1% bovine serum albumin, supplemented with insulin, transferrin, and selenium (its), with or without fibroblast growth factor 7 (fgf7), and were observed for 14 days. |
2019-04-26 |
2023-08-13 |
mouse |
| Xiaofang Xu, Victoria L Browning, Jon S Odoric. Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells. Mechanisms of development. vol 128. issue 7-10. 2012-03-19. PMID:21855631. |
further differentiation occurs after ebs are embedded in matrigel and cultured in serum-free media containing insulin, transferrin, selenium, fgf7, nicotinamide, islet neogenesis associated peptide (ingap) and exendin-4, a long acting glp-1 agonist. |
2012-03-19 |
2023-08-12 |
human |
| J M Shannon, S A Gebb, L D Nielse. Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme-free culture. Development (Cambridge, England). vol 126. issue 8. 1999-06-01. PMID:10079230. |
deletion studies showed that serum, insulin, cholera toxin, and fgf7 were necessary for maximum growth. |
1999-06-01 |
2023-08-12 |
rat |
| J M Shannon, S A Gebb, L D Nielse. Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme-free culture. Development (Cambridge, England). vol 126. issue 8. 1999-06-01. PMID:10079230. |
day-13 embryonic rat tracheal epithelium was separated from its mesenchyme, enrobed in growth factor-reduced matrigel, and cultured for up to 7 days in medium containing charcoal-stripped serum, insulin, epidermal growth factor, hepatocyte growth factor, cholera toxin, fibroblast growth factor 1 (fgf1), and keratinocyte growth factor (fgf7). |
1999-06-01 |
2023-08-12 |
rat |