| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna M Jermakowicz, Alison M Kurimchak, Katherine J Johnson, Florence Bourgain-Guglielmetti, Simon Kaeppeli, Maurizio Affer, Hari Pradhyumnan, Robert K Suter, Winston Walters, Maria Cepero, James S Duncan, Nagi G Aya. RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma. Scientific reports. vol 14. issue 1. 2024-04-23. PMID:38654040. |
to identify the temporal order of resistance mechanisms in gbm we performed quantitative proteomics using multiplex-inhibitor bead mass spectrometry and demonstrated that intrinsic resistance to bet inhibitors in gbm treatment occurs rapidly within hours and involves the fibroblast growth factor receptor 1 (fgfr1) protein. |
2024-04-23 |
2024-04-26 |
Not clear |
| Chieh-Jen Wu, Yu-He Li, Hsin-Hung Che. Paricalcitol improved cardiac hypertrophy and fibrosis through upregulation of fibroblast growth factor-23 and downregulation of transforming growth factor-beta in a rat model of isoproterenol-induced cardiomyopathy. The Chinese journal of physiology. vol 66. issue 5. 2023-11-06. PMID:37929341. |
injection of paricalcitol could reduce collagen and transforming growth factor-beta 1 (tgf-β1) levels while activating fibroblast growth factor receptor 1 (fgfr1) and fibroblast growth factor-23 (fgf23) without the help of klotho, thereby reducing myocardial hypertrophy and fibrosis. |
2023-11-06 |
2023-11-08 |
rat |
| Ericka Patricia da Silva, Geórgia da Silva Feltran, Sérgio Alexandre Alcântara Dos Santos, Rodrigo Cardoso de Oliveira, Rahyza I F Assis, Luis Antônio Justulin Junior, Denise Carleto Andia, Willian F Zambuzzi, Alexandra Latini, Rodrigo A Foganholi da Silv. Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus. Brain research. 2023-01-12. PMID:36634900. |
however, transcriptional regulation mediated by dna methylation was observed only for the osteokine receptors, fgfr1(fibroblast growth factor receptor 1) in the striatum and gpr158 (g protein-coupled receptor 158) in the hippocampus. |
2023-01-12 |
2023-08-14 |
rat |
| Kang Qian, Xiaoyan Bao, Yixian Li, Pengzhen Wang, Qian Guo, Peng Yang, Shuting Xu, Fazhi Yu, Ran Meng, Yunlong Cheng, Dongyu Sheng, Jinxu Cao, Minjun Xu, Jing Wu, Tianying Wang, Yonghui Wang, Qiong Xie, Wei Lu, Qizhi Zhan. Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer's Disease. ACS nano. 2022-07-15. PMID:35839463. |
meanwhile, based on fibroblast growth factor receptor 1(fgfr1) overexpression in both the blood-brain barrier and cholinergic neuron, an fgfr1 ligand-fgl peptide was modified on the nanosystem (fgl-np(cit)/hnss) to achieve 4.8-fold enhanced accumulation in brain with preferred distribution into cholinergic neurons in the diseased region. |
2022-07-15 |
2023-08-14 |
mouse |
| Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Ha. Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis. Cellular and molecular life sciences : CMLS. vol 79. issue 6. 2022-05-13. PMID:35562616. |
we then revealed that downregulated astrocytic fibroblast growth factor 2 (fgf2) and nuclear fibroblast growth factor receptor 1 (fgfr1) of neurons are key pathogenic factors for reducing glutamatergic synaptogenesis. |
2022-05-13 |
2023-08-13 |
mouse |
| Shuting Zheng, Jianfen Wu, Shenghan Xiang, Yuwei Zang, Dan Kong, Xiping Wei, Wenxiu Sun, Wei L. An fgf21-like gene from swamp eel (Monopterus albus): Recombinant expression and its potential roles in glucose and lipid homeostasis. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2022-02-21. PMID:35189343. |
furthermore, rfgf21 significantly upregulated the mrna expression levels of peroxisome proliferators-activated receptor alpha (pparα), β-klotho, fibroblast growth factor receptor 1 (fgfr1), phosphoenolpyruvate carboxykinase (pepck), glucose transporter 1 (glut1), and glucose transporter 4 (glut4) in t1dm mouse livers. |
2022-02-21 |
2023-08-13 |
mouse |
| Anna Junga, Ivo Siņicins, Aigars Pētersons, Māra Pilman. Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2021-12-17. PMID:34915763. |
megaureter tissues of 14 children were stained with hematoxylin and eosin as well as with immunohistochemistry for protein gene product 9.5, nerve growth factor receptor, transforming growth factor beta 1 (tgfβ1), fibroblast growth factor receptor 1 (fgfr1), matrix metalloproteinase 2 (mmp-2), angiotensin 2 receptor type 2, and sonic hedgehog (shh) protein. |
2021-12-17 |
2023-08-13 |
Not clear |
| Keith C S Sia, Ling Zhong, Chelsea Mayoh, Murray D Norris, Michelle Haber, Glenn M Marshall, Mark J Raftery, Richard B Loc. Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in Molecular cancer research : MCR. vol 18. issue 12. 2021-09-27. PMID:32801162. |
interestingly, tslp also increased p-tyr of insulin growth factor 1 receptor (igf1r) and fibroblast growth factor receptor 1 (fgfr1), both of which can be targeted with small-molecule inhibitors. |
2021-09-27 |
2023-08-13 |
Not clear |
| Shlok Jindal, S Chockalingam, Siddhartha Sankar Ghosh, Gopinath Packirisam. Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics. Translational research : the journal of laboratory and clinical medicine. vol 235. 2021-08-13. PMID:33582245. |
asodn, antisense oligodeoxynucleotides; bmps, bone morphogenetic proteins; bmscs, bone marrow stem cells; bg, bioglass; cx, connexin; cxre, connexin-responsive elements; cocr nps, cobalt-chromium nanoparticles; cgamp, cyclic guanosine monophosphate-adenosine monophosphate; camp, cyclic adenosine monophosphate; erk1/2, extracellular signal-regulated kinase 1/2; emt, epithelial-mesenchymal transition; epa, eicosapentaenoic acids; fgfr1, fibroblast growth factor receptor 1; frap, fluorescence recovery after photobleaching; 5-fu, 5-fluorouracil; gj, gap junction; gjic, gap junctional intercellular communication; hgprtase, hypoxanthine phosphoribosyltransferase; hsv-tk, herpes virus thymidine kinase; hsa, human serum albumin; ha, hyaluronic acid; hdac, histone deacetylase; iri, ischemia reperfusion injury; il-6, interleukin-6; il-8, interleukin-8; ionps, iron-oxide nanoparticles; jnk, c-jun n-terminal kinase; lamp, local activation of molecular fluorescent probe; mscs, mesenchymal stem cells; mmp, matrix metalloproteinase; mi, myocardial infarction; mapk, mitogen-activated protein kinase; nf-κb, nuclear factor kappa b; no, nitric oxide; pkc, protein kinase c; qds, quantum dots; roi, region of interest; rgo, reduced graphene oxide; sirna, small interfering rna; tgf-β1, transforming growth factor-β1; tnf-α, tumor necrosis factor-α; ucn, upconversion nanoparticles; vegf, vascular endothelial growth factor. |
2021-08-13 |
2023-08-13 |
human |
| Aiping Li, Jing Tian, Jianwen Yang, Xiang Ren, Zhiwen Zhou, Wensheng Zho. Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470768. |
weight measurement, sucrose preference test, open-field test and forced swim test were performed to evaluate the behavioral changes, and then western blot and real-time quantitative pcr were used to detect the expression level of fgf9, fibroblast growth factor receptor 1 (fgfr1) and receptor 3 (fgfr3) in the dentate gyrus of rat hippocampus. |
2021-06-18 |
2023-08-13 |
rat |
| Calixto-Hope G Lucas, Rohit Gupta, Pamela Doo, Julieann C Lee, Cathryn R Cadwell, Biswarathan Ramani, Jeffrey W Hofmann, Emily A Sloan, Bette K Kleinschmidt-DeMasters, Han S Lee, Matthew D Wood, Marjorie Grafe, Donald Born, Hannes Vogel, Shahriar Salamat, Diane Puccetti, David Scharnhorst, David Samuel, Tabitha Cooney, Elaine Cham, Lee-Way Jin, Ziad Khatib, Ossama Maher, Gabriel Chamyan, Carole Brathwaite, Serguei Bannykh, Sabine Mueller, Cassie N Kline, Anu Banerjee, Alyssa Reddy, Jennie W Taylor, Jennifer L Clarke, Nancy Ann Oberheim Bush, Nicholas Butowski, Nalin Gupta, Kurtis I Auguste, Peter P Sun, Jarod L Roland, Corey Raffel, Manish K Aghi, Philip Theodosopoulos, Edward Chang, Shawn Hervey-Jumper, Joanna J Phillips, Melike Pekmezci, Andrew W Bollen, Tarik Tihan, Susan Chang, Mitchel S Berger, Arie Perry, David A Solomo. Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32859279. |
the fgfr1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (lgnet) subtypes including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor (dnt), rosette-forming glioneuronal tumor (rgnt), and extraventricular neurocytoma (evn). |
2021-05-31 |
2023-08-13 |
Not clear |
| Kuei-Ling Tung, Kai-Yuan Chen, Marcos Negrete, Tianyi Chen, Alexias Safi, Abed Alhalim Aljamal, Lingyun Song, Gregory E Crawford, Shengli Ding, David S Hsu, Xiling She. Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance. Genes & diseases. vol 8. issue 2. 2021-05-18. PMID:33997167. |
crispr/cas9 silencing of fibroblast growth factor receptor 1 (fgfr1) and oxytocin receptor (oxtr) helped overcome oxaliplatin resistance. |
2021-05-18 |
2023-08-13 |
Not clear |
| Chien-Chia Su, Wei-Ting Ho, Fu-Ti Peng, Chia-Mao Gao, Tzuu-Shuh Jou, I-Jong Wan. Exploring a peptidomimetic approach of N-cadherin in modulating fibroblast growth factor receptor signaling for corneal endothelial regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-22. PMID:32654299. |
in present study, we demonstrated that bfgf not only activated the canonical fibroblast growth factor receptor 1 (fgfr1) tyrosine kinase pathway, but also further upregulated matrix metalloproteinase activity to cleave n-cadherin into n-terminus and c-terminus fragments, which activated the classical fgfr1 tyrosine kinase pathway and a cryptic β-catenin pathway to affect corneal proliferation and enmt, respectively. |
2021-03-22 |
2023-08-13 |
rat |
| Ricards Kaulins, Laura Ramona Rozite, Mara Pilmane, Aigars Peterson. Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue. Diagnostics (Basel, Switzerland). vol 11. issue 2. 2021-03-16. PMID:33673194. |
therefore the aim of our work was to evaluate growth factors (transforming growth factor-beta (tgf-β), basic fibroblast growth factor (bfgf), insulin-like growth factor 1 (igf-1), hepatocyte growth factor (hgf)) and their receptors (fibroblast growth factor receptor 1 (fgfr1), insulin-like growth factor 1 (igf-1r)), muscle (dystrophin, myosin, alpha actin) and nerve quality (nerve growth factor (ngf), nerve growth factor receptor (ngfr), neurofilaments (nf)) factors, local defense factors (ß-defensin 2, ß-defensin 4), programmed cell death (tunel), and separate gene (wnt-1) expression in human pathological material to find immunohistochemical marker differences between the control and the cdh patient groups. |
2021-03-16 |
2023-08-13 |
human |
| Malalage N Peiris, Fangda Li, Daniel J Donoghu. BCR: a promiscuous fusion partner in hematopoietic disorders. Oncotarget. vol 10. issue 28. 2020-02-25. PMID:31105873. |
bcr has been discovered fused to additional tyrosine kinases, including: fibroblast growth factor receptor 1 (fgfr1), platelet-derived growth factor receptor alpha (pdgfra), ret proto-oncogene (ret), and janus kinase 2 (jak2). |
2020-02-25 |
2023-08-13 |
Not clear |
| Peng Chen, Hongguang Zhang, Qingtao Zhang, Wei Zhou, Yongbing Deng, Xi Hu, Lianyang Zhan. Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-14. PMID:31551405. |
basic fibroblast growth factor reduces permeability and apoptosis of human brain microvascular endothelial cells in response to oxygen and glucose deprivation followed by reoxygenation via the fibroblast growth factor receptor 1 (fgfr1)/erk pathway. |
2020-02-14 |
2023-08-13 |
human |
| Inmaculada Pereda-Pérez, Azucena Valencia, Shishir Baliyan, Ángel Núñez, Ancor Sanz-García, Berta Zamora, Raquel Rodríguez-Fernández, José Antonio Esteban, César Vener. Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. Neurobiology of aging. vol 78. 2019-07-08. PMID:30928883. |
interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (fgf2), whereas fibroblast growth factor receptor 1 (fgfr1) levels only increased after long-term isolation. |
2019-07-08 |
2023-08-13 |
rat |
| Mark Z Chen, Joshua C Chang, Jose Zavala-Solorio, Lance Kates, Minh Thai, Annie Ogasawara, Xiaobo Bai, Sean Flanagan, Victor Nunez, Khanhky Phamluong, James Ziai, Robert Newman, Søren Warming, Ganesh Kolumam, Junichiro Sonod. FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes. Molecular metabolism. vol 6. issue 11. 2019-01-16. PMID:29107292. |
fibroblast growth factor 21 (fgf21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of fibroblast growth factor receptor 1 (fgfr1) and the requisite coreceptor βklotho. |
2019-01-16 |
2023-08-13 |
Not clear |
| Liang Gong, Xiangdong Zhou, Jingxiang Yang, Yongyuan Jiang, Heping Yan. Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells. Oncology reports. vol 37. issue 1. 2017-03-13. PMID:28004110. |
phosphorylation levels of fibroblast growth factor receptor 1 (fgfr1), extracellular signal-related kinase 1/2 (erk1/2), and matrix metalloproteinase-9 (mmp-9) in the sclc cells were also significantly increased. |
2017-03-13 |
2023-08-13 |
Not clear |
| Suping Qin, Dexu Sun, Hui Li, Xiangyang Li, Wei Pan, Chao Yan, Renxian Tang, Xiaomei Li. The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26552406. |
shh, ptch, smo, and gli molecules were highly expressed in rat ra-synovial fibroblast (ra-sf); after blocking the shh-gli signaling pathway with a gli specific inhibitor, gli-antagonist 61 (gant61), ra-sf proliferation was inhibited in a dose-dependent manner and the apoptosis rate of ra-sf was increased as well; the expression levels of fibroblast growth factor receptor 1 (fgfr1) and fgfr3 declined in sf cells after gant61 treatment. |
2017-01-06 |
2023-08-13 |
human |