| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Negar Asadian, Andrea Aprico, Moore Chen, Daniel Yuen, Angus P R Johnston, Trevor J Kilpatrick, Michele D Binde. The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3. Glia. 2024-04-04. PMID:38572807. |
conversely, the provision of gas6 to tyro3 ko mice did not significantly improve the density of myelinated axons. |
2024-04-04 |
2024-04-06 |
mouse |
| Niloufar Salehi, Mitra Nourbakhsh, Shokoofe Noori, Hossein Rezaeizadeh, Afshin Zargh. Tehranolid and Artemisinin Effects on Ameliorating Experimental Autoimmune Encephalomyelitis by Modulating Inflammation and Remyelination. Molecular neurobiology. 2023-06-30. PMID:37391648. |
the compounds made no changes in rorγt, nestin, gas6, tyro3, and mertk mrna expression levels in the spinal cord. |
2023-06-30 |
2023-08-14 |
mouse |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Juwen C DuBois, Alex K Ray, Peter Davies, Bridget Shafit-Zagard. Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33121494. |
during experimental autoimmune encephalomyelitis (eae), the mrna expression of mertk, gas6, and axl significantly increase, whereas tyro3 and pros1 remain unchanged. |
2021-09-16 |
2023-08-13 |
Not clear |
| Salman Goudarzi, Shannon E Gilchrist, Sassan Hafiz. Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia. Cells. vol 9. issue 8. 2021-03-31. PMID:32722558. |
here, we characterised the expression of tam receptors and ligands in individual cns glial cell types, observing high expression of gas6 and the tam receptors, mer and axl, in microglia, and high expression of tyro3 in astrocytes. |
2021-03-31 |
2023-08-13 |
mouse |
| Yu-Huei Li, Chieh-Hua Lu, Fu-Huang Lin, Sheng-Chiang Su, Jhih-Syuan Liu, Chang-Hsun Hsieh, Yi-Jen Hung, Yi-Shing Shieh, Chien-Hsing Le. Plasma Growth Arrest-Specific 6 Protein and Genetic Variations in the GAS6 Gene in Patients with Metabolic Syndrome. Metabolic syndrome and related disorders. vol 17. issue 1. 2019-10-25. PMID:30346880. |
recent studies indicate that gas6 and receptors of the tam (tyro3, axl, and mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. |
2019-10-25 |
2023-08-13 |
Not clear |
| Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazaw. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nature communications. vol 9. issue 1. 2018-07-09. PMID:29382817. |
disinhibition of gas6 binding to tyro3 due to pgrn reduction results in activation of pkcα via plcγ, inducing tau phosphorylation at ser203, mislocalization of tau to dendritic spines, and spine loss. |
2018-07-09 |
2023-08-13 |
mouse |
| Rainer Akkermann, Andrea Aprico, Ashwyn A Perera, Helena Bujalka, Alistair E Cole, Junhua Xiao, Judith Field, Trevor J Kilpatrick, Michele D Binde. The TAM receptor Tyro3 regulates myelination in the central nervous system. Glia. vol 65. issue 4. 2018-01-12. PMID:28145605. |
we have previously identified that the protein gas6, a ligand for a family of tyrosine kinase receptors known as the tam (tyro3, axl, and mertk) receptors, directly increases oligodendrocyte induced myelination in vitro. |
2018-01-12 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Salman Goudarzi, Andrea Rivera, Arthur M Butt, Sassan Hafiz. Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination. ASN neuro. vol 8. issue 5. 2017-10-13. PMID:27630207. |
cotreatment of cerebellar slices with gas6 significantly attenuated demyelination as determined by mbp immunostaining, and gas6 activated tyro3 receptor through its phosphorylation. |
2017-10-13 |
2023-08-13 |
mouse |
| Ross C Gruber, Alex K Ray, Christopher T Johndrow, Hillary Guzik, Dominika Burek, Pablo García de Frutos, Bridget Shafit-Zagard. Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 49. 2015-02-19. PMID:25471571. |
during experimental autoimmune encephalomyelitis (eae), wild-type (wt) mice demonstrate a significant induction of gas6, axl, and mertk but not pros1 or tyro3 mrna. |
2015-02-19 |
2023-08-13 |
mouse |
| A L Prieto, S O'Dell, B Varnum, C La. Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17980494. |
in an effort to elucidate the roles of tyro3 and its ligand, the protein growth arrest-specific gene6 (gas6) in the hippocampus and cortex, we performed a detailed study of the localization and signaling of tyro3 polypeptides in rat hippocampal and cortical neurons. |
2008-04-03 |
2023-08-12 |
rat |