| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mosaad A Soltan, Ramdan S Shewita, Omaima A Matroud, Lamya Ahmed Alkeridis, Samy Sayed, Mustafa Shukry, Set A El-Shoboksh. Lignocellulose and probiotic supplementation in broiler chicken diet: effect on growth performance, digestive health, litter quality, and genes expression. Poultry science. vol 103. issue 6. 2024-04-23. PMID:38652957. |
dietary inclusion of lc and or b. subtilis supplementation significantly (p < 0.001) up-regulated hepatic growth-related genes (growth hormone receptor (ghr) and insulin growth factor1 (igf-1)) and antioxidant-related genes (superoxide dismutase 1 (sod1), glutathione peroxidase (gpx1) and uncoupling protein (ucp) and down-regulated (p < 0.001) splenic toll-like receptor 4 (tlrp) gene expression while had no significant effect on splenic interleukin 8 (il8) and tumor necrosis factor (tnf) with the best-obtained results with 1.0% followed by 0.5% lc with b. subtilis supplementation. |
2024-04-23 |
2024-04-26 |
chicken |
| Qin Wang, Jianrong Wang, Xue Zhang, Yiqun Liu, Feng Han, Xuesong Xiang, Yanbin Guo, Zhen-Wu Huan. Increased Expression of PHGDH Under High-Selenium Stress In Vivo. Biological trace element research. 2024-01-26. PMID:38277119. |
the expressions of insulin signaling pathway (pi3k-akt-mtor), glutathione peroxidase 1 (gpx1), selenoprotein n (selenon), 3-phosphoglycerate dehydrogenase (phgdh), serine hydroxymethyltransferases 1 (shmt1), 5,10-methylenetetrahydrofolate reductase (mthfr), and methionine synthase (ms) were analyzed by western blotting (wb) in liver and muscle tissues. |
2024-01-26 |
2024-01-28 |
mouse |
| María Luisa Ojeda, Fátima Nogales, Olimpia Carreras, Eloísa Pajuelo, María Del Carmen Gallego-López, Inés Romero-Herrera, Belén Begines, Jorge Moreno-Fernández, Javier Díaz-Castro, Ana Alcudi. Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats. Nutrients. vol 14. issue 17. 2022-09-09. PMID:36079831. |
this study tests the actions of low-dose selenite and se nanoparticles (senps) on white (wat) and brown adipose tissue (bat) deposition, insulin secretion, and gpx1, irs-1 and foxo3a expression in the wat of adolescent rats as regards oxidative stress, adipocyte length and adipokine secretion. |
2022-09-09 |
2023-08-14 |
rat |
| Jun-Won Yun, Zeping Zhao, Xi Yan, Marko Z Vatamaniuk, Xin Gen Le. Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets. Free radical biology & medicine. vol 134. 2020-04-21. PMID:30703484. |
our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (gpx1) in mice (oe) led to escalated glucose-stimulated insulin secretion and hyperinsulinemia. |
2020-04-21 |
2023-08-13 |
mouse |
| Hitoshi Ueno, Ryo Shimizu, Tomofumi Okuno, Hirofumi Ogino, Tomohiro Arakawa, Koichi Murano, Katsuhiko Nakamur. Effect of Seleno-L-methionine on Oxidative Stress in the Pancreatic Islets of a Short-Term Induced Diabetic Mouse Model in Insufficient Selenium Status. Biological & pharmaceutical bulletin. vol 41. issue 1. 2018-08-13. PMID:29311486. |
these results suggest that although a physiological level of semet improves glucose tolerance by exhibiting insulin-mimetic activity in a short-term induced diabetic mouse model under insufficient se status, the suppression of pancreatic oxidative stress with the induction gpx1 by semet supplementation is unlikely to restore insulin storage and secretion. |
2018-08-13 |
2023-08-13 |
mouse |
| Alastair D Green, Srividya Vasu, Neville H McClenaghan, Peter R Flat. Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells. Pflugers Archiv : European journal of physiology. vol 467. issue 10. 2016-06-27. PMID:25559846. |
measurement of gene expression by reverse-transcription, real-time pcr showed that genes involved with insulin secretion (ins, pdx1, pcsk1, pcsk2, glp1r and gipr), cell-cell communication (gjd2, gja1 and cdh1) and antioxidant defence (sod1, sod2, gpx1 and cat) were significantly upregulated in pseudoislets compared to monolayers, whilst the expression of proapoptotic genes (nos2, mapk8, mapk10 and nfkb1) showed no significant differences. |
2016-06-27 |
2023-08-13 |
human |
| Xuan Yang, Lei Feng, Changjiang Li, Yu L. Tranilast alleviates endothelial dysfunctions and insulin resistance via preserving glutathione peroxidase 1 in rats fed a high-fat emulsion. Journal of pharmacological sciences. vol 124. issue 1. 2014-09-29. PMID:24389817. |
therefore, oxidative stress induced by a relatively short-term high-fat diet could cause the early development of vascular and metabolic abnormalities in rats, and tranilast has a beneficial effect in vascular dysfunctions and insulin resistance via preserving gpx1 and alleviating oxidative stress. |
2014-09-29 |
2023-08-12 |
rat |
| Xinhui Wang, Jun-Won Yun, Xin Gen Le. Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets. Antioxidants & redox signaling. vol 20. issue 2. 2014-08-13. PMID:23795780. |
glutathione peroxidase (gpx) mimic ebselen and superoxide dismutase (sod) mimic copper diisopropylsalicylate (cudips) were used to rescue impaired glucose-stimulated insulin secretion (gsis) in islets of gpx1 and(or) sod1-knockout mice. |
2014-08-13 |
2023-08-12 |
mouse |
| Xin Gen Lei, Marko Z Vatamaniu. Two tales of antioxidant enzymes on β cells and diabetes. Antioxidants & redox signaling. vol 14. issue 3. 2011-04-14. PMID:20618069. |
although knockouts of gpx1 and sod1 each alone or together decreased pancreatic β cell mass and plasma insulin concentrations, these knockouts improved body insulin sensitivity to different extents. |
2011-04-14 |
2023-08-12 |
mouse |
| Erik Schoenmakers, Maura Agostini, Catherine Mitchell, Nadia Schoenmakers, Laura Papp, Odelia Rajanayagam, Raja Padidela, Lourdes Ceron-Gutierrez, Rainer Doffinger, Claudia Prevosto, Jian'an Luan, Sergio Montano, Jun Lu, Mireille Castanet, Nick Clemons, Matthijs Groeneveld, Perrine Castets, Mahsa Karbaschi, Sri Aitken, Adrian Dixon, Jane Williams, Irene Campi, Margaret Blount, Hannah Burton, Francesco Muntoni, Dominic O'Donovan, Andrew Dean, Anne Warren, Charlotte Brierley, David Baguley, Pascale Guicheney, Rebecca Fitzgerald, Alasdair Coles, Hill Gaston, Pamela Todd, Arne Holmgren, Kum Kum Khanna, Marcus Cooke, Robert Semple, David Halsall, Nicholas Wareham, John Schwabe, Lucia Grasso, Paolo Beck-Peccoz, Arthur Ogunko, Mehul Dattani, Mark Gurnell, Krishna Chatterje. Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. The Journal of clinical investigation. vol 120. issue 12. 2011-01-14. PMID:21084748. |
paradoxically, raised ros in affected subjects was associated with enhanced systemic and cellular insulin sensitivity, similar to findings in mice lacking the antioxidant selenoenzyme glutathione peroxidase 1 (gpx1). |
2011-01-14 |
2023-08-12 |
mouse |
| Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin J Shields, Beata Skiba, Lisa M Ooms, Nigel Stepto, Ben Wu, Christina A Mitchell, Nicholas K Tonks, Matthew J Watt, Mark A Febbraio, Peter J Crack, Sofianos Andrikopoulos, Tony Tigani. Reactive oxygen species enhance insulin sensitivity. Cell metabolism. vol 10. issue 4. 2010-01-06. PMID:19808019. |
here we report that mice lacking one of the key enzymes involved in the elimination of physiological ros, glutathione peroxidase 1 (gpx1), were protected from high-fat-diet-induced insulin resistance. |
2010-01-06 |
2023-08-12 |
mouse |
| Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin J Shields, Beata Skiba, Lisa M Ooms, Nigel Stepto, Ben Wu, Christina A Mitchell, Nicholas K Tonks, Matthew J Watt, Mark A Febbraio, Peter J Crack, Sofianos Andrikopoulos, Tony Tigani. Reactive oxygen species enhance insulin sensitivity. Cell metabolism. vol 10. issue 4. 2010-01-06. PMID:19808019. |
the increased insulin sensitivity in gpx1(-/-) mice was attributed to insulin-induced phosphatidylinositol-3-kinase/akt signaling and glucose uptake in muscle and could be reversed by the antioxidant n-acetylcysteine. |
2010-01-06 |
2023-08-12 |
mouse |
| Xin Gen Lei, Wen-Hsing Chen. New roles for an old selenoenzyme: evidence from glutathione peroxidase-1 null and overexpressing mice. The Journal of nutrition. vol 135. issue 10. 2006-01-11. PMID:16177185. |
more intriguingly, mice overexpressing gpx1 develop insulin resistance and obesity, accompanied by a downregulation of insulin-mediated phosphorylations of insulin receptor and akt protein. |
2006-01-11 |
2023-08-12 |
mouse |
| James P McClung, Carol A Roneker, Weipeng Mu, Donald J Lisk, Paul Langlais, Feng Liu, Xin Gen Le. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 24. 2004-08-05. PMID:15184668. |
here we report the development of insulin resistance in mammals with elevated expression of an antioxidant enzyme and suggest that increased gpx1 activity may interfere with insulin function by overquenching intracellular reactive oxygen species required for insulin sensitizing. |
2004-08-05 |
2023-08-12 |
mouse |
| James P McClung, Carol A Roneker, Weipeng Mu, Donald J Lisk, Paul Langlais, Feng Liu, Xin Gen Le. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 24. 2004-08-05. PMID:15184668. |
the objective of our study was to investigate the impact of overexpression of glutathione peroxidase 1 (gpx1), an intracellular selenoprotein that reduces hydrogen peroxide (h(2)o(2)) in vivo, on glucose metabolism and insulin function. |
2004-08-05 |
2023-08-12 |
mouse |