| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
moreover, msa-activated microglia triggered remarkable tau phosphorylation at multiple sites through nlrp3 inflammasome pathway. |
2024-04-23 |
2024-04-26 |
mouse |
| Faith L Anderson, Karl E Biggs, Brynn E Rankin, Matthew C Havrd. NLRP3 inflammasome in neurodegenerative disease. Translational research : the journal of laboratory and clinical medicine. 2022-08-11. PMID:35952982. |
in this review, we highlight evidence from model systems and patients indicating inflammasome activity in neurodegenerative disease associated with the nlrp3 inflammasome's ability to recognize pathologic forms of amyloid-β, tau, and α-synuclein. |
2022-08-11 |
2023-08-14 |
Not clear |
| Siva Prasad Panda, Yogita Dhurandhar, Mehak Agrawa. The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. Mitochondrion. 2022-07-16. PMID:35842181. |
the epileptogenesis in patients with alzheimer's disease dementia (add) and parkinson's disease dementia (pdd) is due to involvement of amyloid plaques (aβ), phosphorylated tau (ptau), parkin, nf-kb and nlrp3 inflammasome.microglia, the prime protective and inflammatory cells in the brain exert crosstalk between mitophagy and inflammation. |
2022-07-16 |
2023-08-14 |
Not clear |
| Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommere. Improved sleep, memory, and cellular pathological features of tauopathy, including the NLRP3 inflammasome, after chronic administration of trazodone in rTg4510 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-03-11. PMID:35273086. |
in a 9-week dosing regimen, trazodone decreased microglial nlrp3 inflammasome expression and phosphorylated p38 mitogen-activated protein kinase levels which correlated with the nlrp3 inflammasome, the upr effector atf4, and total tau levels. |
2022-03-11 |
2023-08-13 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
we here demonstrate for the first time that nlrp3 activation affects tau-associated neurodegeneration and seeded and non-seeded tau pathology, hence affecting key molecular processes in tauopathies. |
2022-02-17 |
2023-08-13 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
we furthermore assessed the effect of nlrp3 deficiency on tau propagation and associated hippocampal atrophy. |
2022-02-17 |
2023-08-13 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
nlrp3 deficiency significantly decreased prion-like seeding and propagation of tau pathology, reflected in decreased tau pathology in ipsi- and contralateral hippocampus and cortex in tau.nlrp3-/- following tau seeding. |
2022-02-17 |
2023-08-13 |
mouse |
| Cira Dansokho, Michael Thomas Henek. Neuroinflammatory responses in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 5. 2019-11-04. PMID:29273951. |
this review discusses recent knowledge on microglia responses toward amyloid and tau pathology in ad, focusing on the role of toll-like receptors and nod-like receptor protein 3 (nlrp3) inflammasome activation in microglial cells. |
2019-11-04 |
2023-08-13 |
mouse |