| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria V Barbolin. Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma. Cancers. vol 14. issue 18. 2022-09-23. PMID:36139693. |
here, i used models of platinum-resistant and created models of platinum/paclitaxel-resistant high-grade serous ovarian carcinoma to examine the impact of reducing tau expression on cell survival and tumor burden in cell culture and xenograft and syngeneic models of the disease. |
2022-09-23 |
2023-08-14 |
Not clear |
| Anne Fourest-Lieuvin, Angélique Vinit, Béatrice Blot, Anthime Perrot, Eric Denarier, Frédéric Saudou, Isabelle Arna. Controlled tau cleavage in cells reveals abnormal localizations of tau fragments. Neuroscience. 2022-08-22. PMID:35995336. |
based on the data presented here, inducible cleavage of tau by the tev protease appears to be a valuable tool to reproduce tau fragmentation in cells and study the resulting consequences on cell physiology. |
2022-08-22 |
2023-08-14 |
Not clear |
| Jessica S Fortin, Kuang-Wei Wang, Hsiao T Chien, Min-Hao Ku. A Phenotypic-based Drug Discovery Approach to Inhibit the Misfolding of Hyperphosphorylated Tau Isoform 1N4R. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554965. |
instead of the unmodified tau that shows minimal effects on cell viability, our research focuses on the control of p-tau that possesses disease-relevant molecular features, including hyperphosphorylation and cytotoxicity. |
2022-05-13 |
2023-08-13 |
human |
| David Halpern, Hideki Fujioka, James B Grotber. The effect of viscoelasticity on the stability of a pulmonary airway liquid layer. Physics of fluids (Woodbury, N.Y. : 1994). vol 22. issue 1. 2021-10-20. PMID:20157445. |
the film thickness parameter epsilon and the weissenberg number we also have a significant effect on the maximum shear stress on tube wall, max(tau(w)), and thus, potentially, an impact on cell damage. |
2021-10-20 |
2023-08-12 |
Not clear |
| Benjamin B Tournier, Kelly Ceyzériat, Farha N Bouteldja, Philippe Mille. Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes. ACS omega. vol 6. issue 29. 2021-08-03. PMID:34337211. |
the dose-effect on cell death in response to aβ and tau was observed but without alterations of tspo density and polymerization. |
2021-08-03 |
2023-08-13 |
Not clear |
| Shruti Shandilya, Kavindra Kumar Kesari, Janne Ruokolaine. Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells. Antioxidants (Basel, Switzerland). vol 10. issue 6. 2021-07-10. PMID:34202933. |
to understand the neuroprotective effect of vitamin k2 during metabolic complications, sh-sy5y cells were treated with streptozotocin for 24 h and menadione for 2 h in a dose-dependent manner, followed by post-treatment of vitamin k2 for 5 h. the modulating effects of vitamin k2 on cell viability, lactate dehydrogenase release, reactive oxygen species (ros), mitochondrial membrane potential, er stress marker (chop), an indicator of unfolded protein response (upr), inositol requiring enzyme 1 (p-ire1α), glycogen synthase kinase 3 (gsk3α/β), total tau and aβ42 were studied. |
2021-07-10 |
2023-08-13 |
Not clear |
| Mengyu Liu, Dexin Sui, Thomas Dexheimer, Stacy Hovde, Xiexiong Deng, Kuang-Wei Wang, Hsin Lian Lin, Hsiao-Tien Chien, Hye Kyong Kweon, Nora Sheen Kuo, Christopher A Ayoub, Daniela Jimenez-Harrison, Philip C Andrews, Roland Kwok, Daniel A Bochar, Jeff Kuret, Jessica Fortin, Yeou-Guang Tsay, Min-Hao Ku. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Molecular neurobiology. vol 57. issue 11. 2021-06-29. PMID:32780352. |
in stark contrast to unmodified tau that required an aggregation inducer, and which had minimal effects on cell functions, p-tau formed inducer-free fibrils that triggered a spike of mitochondrial superoxide, induced apoptosis, and caused cell death at sub-micromolar concentrations. |
2021-06-29 |
2023-08-13 |
Not clear |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
insulin resistance or dysfunction of insulin signaling is a universal feature of t2d, the main culprit for altered glucose metabolism and its interdependence on cell death pathways, forming the basis of linking t2d with ad as it may exacerbate aβ accumulation, tau hyperphosphorylation and devastates glucose transportation, energy metabolism, hippocampal framework and promulgate inflammatory pathways. |
2021-03-29 |
2023-08-13 |
Not clear |
| Shuo Tu, Xiali Zhang, Daya Luo, Zhuoqi Liu, Xiaohong Yang, Huifang Wan, Lehan Yu, Hua Li, Fusheng Wa. Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells. Experimental and therapeutic medicine. vol 10. issue 1. 2020-10-01. PMID:26170934. |
therefore, the puma gene was shown to have an important role in mechanism underlying the effect that tau exerts on cell proliferation and apoptosis in hhcc hepg2 cells. |
2020-10-01 |
2023-08-13 |
human |
| Shuo Tu, Xiali Zhang, Daya Luo, Zhuoqi Liu, Xiaohong Yang, Huifang Wan, Lehan Yu, Hua Li, Fusheng Wa. Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells. Experimental and therapeutic medicine. vol 10. issue 1. 2020-10-01. PMID:26170934. |
addition of 20-160 mm tau was shown to have a significant inhibitory effect on cell proliferation, while promoting the induction of hhcc hepg2 cell apoptosis (p<0.05). |
2020-10-01 |
2023-08-13 |
human |
| Song Chen, Su-Ting Chen, Yan Sun, Zheng Xu, Ying Wang, Si-Yuan Yao, Wen-Bing Yao, Xiang-Dong Ga. Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer's disease. Redox biology. vol 22. 2019-11-25. PMID:30785085. |
we report here a study in vivo and in vitro of the neuroprotective effects of fgf21 on cell apoptosis, tau hyperphosphorylation and oxidative stress induced by amyloid β-peptide 25-35. |
2019-11-25 |
2023-08-13 |
rat |
| Yue Hu, Kai-Yi Zhou, Ze-Jian Wang, Yang Lu, Ming Yi. N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H Chemico-biological interactions. vol 272. 2017-06-20. PMID:28526263. |
the transfected human embryonic kidney 293 (hek 293) cells with or without tau 411 plasmid were used to evaluate the effect of tau protein on cell viability. |
2017-06-20 |
2023-08-13 |
human |
| Anne-Laure Bougé, Marie-Laure Parmentie. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Disease models & mechanisms. vol 9. issue 3. 2016-12-13. PMID:26822478. |
here, we studied the effect of an excess of human tau (htau) protein on cell mitosis in vivo. |
2016-12-13 |
2023-08-13 |
human |
| Li Li, Zhi-Peng Xu, Gong-Ping Liu, Cheng Xu, Zhi-Hao Wang, Xiao-Guang Li, En-Jie Liu, Juan Zeng, Da-Min Chai, Wen-Long Yao, Jian-Zhi Wan. Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells. PloS one. vol 10. issue 3. 2016-04-22. PMID:25822823. |
here, we investigated the individual effect of six different isoforms of tau on cell proliferation and the possible mechanisms by transient expression of egfp-labeled tau isoform plasmid in n2a cells. |
2016-04-22 |
2023-08-13 |
human |
| Katharina Rüben, Anne Wurzlbauer, Agnes Walte, Wolfgang Sippl, Franz Bracher, Walter Becke. Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors. PloS one. vol 10. issue 7. 2016-04-21. PMID:26192590. |
in cellular assays, annh75 dose-dependently reduced the phosphorylation of three known dyrk1a substrates (sf3b1, sept4, and tau) without negative effects on cell viability. |
2016-04-21 |
2023-08-13 |
Not clear |
| Veronika Seiberlich, Nina G Bauer, Lisa Schwarz, Charles Ffrench-Constant, Olaf Goldbaum, Christiane Richter-Landsber. Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia. vol 63. issue 9. 2016-04-13. PMID:25847153. |
to further elucidate the functional significance of tau in oligodendrocytes, we have downregulated tau by sirna technology and studied the effects on cell differentiation and neuron-glia contact formation. |
2016-04-13 |
2023-08-13 |
Not clear |
| S Chen, F-M An, L Yin, A-R Liu, D-K Yin, W-B Yao, X-D Ga. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience. vol 256. 2014-08-27. PMID:24183963. |
herein, we investigated the effects of glp-1 receptor mediates on cell toxicity and tau hyperphosphorylation induced by advanced glycation end products (ages), which are associated with glucose toxicity, and the molecular mechanism in pc12 cells and the primary hippocampal neurons. |
2014-08-27 |
2023-08-12 |
rat |
| Daniel Petroni, Jeffrey Tsai, Debasis Mondal, William Georg. Attenuation of low dose methylmercury and glutamate induced-cytotoxicity and tau phosphorylation by an N-methyl-D-aspartate antagonist in human neuroblastoma (SHSY5Y) cells. Environmental toxicology. vol 28. issue 12. 2014-05-05. PMID:21976409. |
neuroblastoma cells (sh-sy5y) were used in a cell culture model to study effects of mehg, glutamate (glu), a calcium chelator (bapta-am), and a noncompetitive nmda antagonist, mk-801 on cell growth, cell survival, and phosphorylation of tau protein, as a measure of cellular events associated with tauopathies. |
2014-05-05 |
2023-08-12 |
human |
| Daniel Petroni, Jeffrey Tsai, Krishna Agrawal, Debasis Mondal, William Georg. Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells. Environmental toxicology. vol 27. issue 9. 2013-05-06. PMID:21254321. |
pretreatment of nb cells with the antioxidant, n-acetylcysteine (1.25 mm) and the calpain inhibitor, mdl-28170 (10 μm), significantly attenuated the effects of mehg (50 and 100 nm) on cell viability as well as on tau phosphorylation. |
2013-05-06 |
2023-08-12 |
human |
| Daniel Petroni, Jeffrey Tsai, Krishna Agrawal, Debasis Mondal, William Georg. Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells. Environmental toxicology. vol 27. issue 9. 2013-05-06. PMID:21254321. |
neuroblastoma (nb) cells (sh-sy5y) were used in the cell culture model to study low-dose effects of mehg on cell growth, cell survival, reactive oxygen species (ros), and the phosphorylation of tau protein, as a measure of potential markers of cellular events associated with tauopathies. |
2013-05-06 |
2023-08-12 |
human |