| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunguang Qiu, Yuan Hou, Dhruv Gohel, Yadi Zhou, Jielin Xu, Marina Bykova, Yuxin Yang, James B Leverenz, Andrew A Pieper, Ruth Nussinov, Jessica Z K Caldwell, J Mark Brown, Feixiong Chen. Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer's disease. Cell reports. vol 43. issue 5. 2024-04-23. PMID:38652661. |
we demonstrate that phenethylamine and agmatine significantly reduce tau hyperphosphorylation (p-tau181 and p-tau205) in ad patient induced pluripotent stem cell-derived neurons. |
2024-04-23 |
2024-04-26 |
human |
| Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggart. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology. 2024-01-03. PMID:38168389. |
cholesterol dysregulation drives seed-dependent tau aggregation in patient stem cell-derived models of tauopathy. |
2024-01-03 |
2024-01-06 |
Not clear |
| Elisa Giunti, Roberto Collu, Sarah Daley, Henry Querfurth, Peter Morin, Richard Killick, Rachel D Melamed, Weiming Xi. Reduction of Phosphorylated Tau in Alzheimer's Disease Induced Pluripotent Stem Cell-Derived Neuro-Spheroids by Rho-Associated Coiled-Coil Kinase Inhibitor Fasudil. Journal of Alzheimer's disease : JAD. 2023-11-26. PMID:38007655. |
reduction of phosphorylated tau in alzheimer's disease induced pluripotent stem cell-derived neuro-spheroids by rho-associated coiled-coil kinase inhibitor fasudil. |
2023-11-26 |
2023-11-28 |
Not clear |
| Kimberly L Fiock, Jordan N Hook, Marco M Heft. Determinants of astrocytic pathology in stem cell models of primary tauopathies. Acta neuropathologica communications. vol 11. issue 1. 2023-10-06. PMID:37803326. |
we then found that stem cell-derived astrocytes preferentially take up long isoform (4r) recombinant tau and that this uptake is impaired by induction of reactivity with inflammatory stimuli or nutritional stress. |
2023-10-06 |
2023-10-15 |
human |
| Kimberly L Fiock, Jordan N Hook, Marco M Heft. Determinants of astrocytic pathology in stem cell models of primary tauopathies. Acta neuropathologica communications. vol 11. issue 1. 2023-10-06. PMID:37803326. |
we used a combination of rna in situ hybridization and immunofluorescence in post-mortem human brain tissue, as well as tau uptake studies in human stem cell-derived astrocytes, to determine the origins of astrocytic tau in 4r tauopathies. |
2023-10-06 |
2023-10-15 |
human |
| Yonghe Li, Jesse R Macyczko, Chia-Chen Liu, Guojun B. ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease. Neurobiology of aging. vol 115. 2022-04-22. PMID:35453035. |
studies of ad patients, ad patient-specific induced pluripotent stem cell-derived neurons and cerebral organoids, and human apoe4-expressing and apoe-deficient mouse models clearly demonstrate that apoe4 provokes neuroinflammation, impairs cerebrovasculature, and exacerbates amyloid and tau pathologies. |
2022-04-22 |
2023-08-13 |
mouse |
| Thomas K Karikari, David A Nagel, Alastair Grainger, Charlotte Clarke-Bland, James Crowe, Eric J Hill, Kevin G Moffa. Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31338022. |
however, shared internalization mechanisms were observed: endocytosed oligomers were distributed in the cytoplasm and nucleus of sh-sy5y cells and the neurites and soma of human induced pluripotent stem cell-derived neurons, where they co-localized with endogenous tau and the nuclear protein nucleolin. |
2020-09-30 |
2023-08-13 |
human |
| Israel Hernandez, Gabriel Luna, Jennifer N Rauch, Surya A Reis, Michel Giroux, Celeste M Karch, Daniel Boctor, Youssef E Sibih, Nadia J Storm, Antonio Diaz, Susmita Kaushik, Cezary Zekanowski, Alexander A Kang, Cassidy R Hinman, Vesna Cerovac, Elmer Guzman, Honjun Zhou, Stephen J Haggarty, Alison M Goate, Steven K Fisher, Ana M Cuervo, Kenneth S Kosi. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science translational medicine. vol 11. issue 485. 2020-04-27. PMID:30918111. |
we finally showed in mouse brain and in human induced pluripotent stem cell-derived neurons a normal developmental increase in rhes that was initially suppressed by tau mutations. |
2020-04-27 |
2023-08-13 |
mouse |
| Thomas K Karikari, David A Nagel, Alastair Grainger, Charlotte Clarke-Bland, Eric J Hill, Kevin G Moffa. Preparation of stable tau oligomers for cellular and biochemical studies. Analytical biochemistry. vol 566. 2019-11-27. PMID:30315761. |
furthermore, the use of this approach to study the propagation of labeled extracellular tau k18 oligomers into human neuroblastoma cells and human stem cell-derived neurons is described. |
2019-11-27 |
2023-08-13 |
human |
| Hans-Ulrich Klein, Cristin McCabe, Elizabeta Gjoneska, Sarah E Sullivan, Belinda J Kaskow, Anna Tang, Robert V Smith, Jishu Xu, Andreas R Pfenning, Bradley E Bernstein, Alexander Meissner, Julie A Schneider, Sara Mostafavi, Li-Huei Tsai, Tracy L Young-Pearse, David A Bennett, Philip L De Jage. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559478. |
finally, we found that tau overexpression in induced pluripotent stem cell-derived neurons altered chromatin structure and that these effects could be blocked by a small molecule predicted to reverse the tau effect. |
2019-05-21 |
2023-08-13 |
mouse |
| Vanessa J Hall, Maiken M Lindblad, Jannik E Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A Rasmussen, Daniela Volke, Thole Zuchner, Poul Hytte. Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig. Disease models & mechanisms. vol 8. issue 10. 2016-07-19. PMID:26398935. |
impaired app activity and altered tau splicing in embryonic stem cell-derived astrocytes obtained from an appsw transgenic minipig. |
2016-07-19 |
2023-08-13 |
human |
| Teresa Sposito, Elisavet Preza, Colin J Mahoney, Núria Setó-Salvia, Natalie S Ryan, Huw R Morris, Charles Arber, Michael J Devine, Henry Houlden, Thomas T Warner, Trevor J Bushell, Michele Zagnoni, Tilo Kunath, Frederick J Livesey, Nick C Fox, Martin N Rossor, John Hardy, Selina Wra. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Human molecular genetics. vol 24. issue 18. 2016-05-31. PMID:26136155. |
developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in mapt. |
2016-05-31 |
2023-08-13 |
human |
| Chia-Yu Chang, Sheng-Mei Chen, Huai-En Lu, Syu-Ming Lai, Ping-Shan Lai, Po-Wen Shen, Pei-Ying Chen, Ching-I Shen, Horng-Jyh Harn, Shinn-Zong Lin, Shiaw-Min Hwang, Hong-Lin S. N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons. Scientific reports. vol 5. 2016-04-01. PMID:25735452. |
accumulated amyloid deposits, tau protein hyperphosphorylation and tau intracellular redistribution emerged rapidly in ds neurons within 45 days but not in normal embryonic stem cell-derived neurons. |
2016-04-01 |
2023-08-13 |
Not clear |
| Mariangela Iovino, Sylvia Agathou, Ana González-Rueda, Martin Del Castillo Velasco-Herrera, Barbara Borroni, Antonella Alberici, Timothy Lynch, Sean O'Dowd, Imbisaat Geti, Daniel Gaffney, Ludovic Vallier, Ole Paulsen, Ragnhildur Thóra Káradóttir, Maria Grazia Spillantin. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26220942. |
induced pluripotent stem cell-derived neurons recapitulate developmental tau expression, showing the adult brain tau isoforms after several months in culture. |
2016-02-09 |
2023-08-13 |
human |
| Mariangela Iovino, Sylvia Agathou, Ana González-Rueda, Martin Del Castillo Velasco-Herrera, Barbara Borroni, Antonella Alberici, Timothy Lynch, Sean O'Dowd, Imbisaat Geti, Daniel Gaffney, Ludovic Vallier, Ole Paulsen, Ragnhildur Thóra Káradóttir, Maria Grazia Spillantin. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Brain : a journal of neurology. vol 138. issue Pt 11. 2016-02-09. PMID:26220942. |
early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with mapt mutations. |
2016-02-09 |
2023-08-13 |
human |
| Jerome Mertens, Kathrin Stüber, Daniel Poppe, Jonas Doerr, Julia Ladewig, Oliver Brüstle, Philipp Koc. Embryonic stem cell-based modeling of tau pathology in human neurons. The American journal of pathology. vol 182. issue 5. 2014-03-25. PMID:23499461. |
herein, we explored whether human embryonic stem cell-derived neural stem cells can be exploited to study consequences of an overexpression of 2n4r tau (two normal n-terminal and four mt-binding domains; n-tau) versus pseudohyperphosphorylated tau (p-tau) directly in human neurons. |
2014-03-25 |
2023-08-12 |
human |
| Jessica E Young, Lawrence S B Goldstei. Alzheimer's disease in a dish: promises and challenges of human stem cell models. Human molecular genetics. vol 21. issue R1. 2013-04-05. PMID:22865875. |
stem cell-derived neurons from patients with familial and sporadic ad and down's syndrome recapitulate human disease phenotypes such as amyloid β peptide production, hyperphosphorylation of tau protein and endosomal abnormalities. |
2013-04-05 |
2023-08-12 |
human |
| Mariangela Iovino, Rickie Patani, Colin Watts, Siddharthan Chandran, Maria Grazia Spillantin. Human stem cell-derived neurons: a system to study human tau function and dysfunction. PloS one. vol 5. issue 11. 2011-04-27. PMID:21085657. |
human stem cell-derived neurons: a system to study human tau function and dysfunction. |
2011-04-27 |
2023-08-12 |
human |
| Mariangela Iovino, Rickie Patani, Colin Watts, Siddharthan Chandran, Maria Grazia Spillantin. Human stem cell-derived neurons: a system to study human tau function and dysfunction. PloS one. vol 5. issue 11. 2011-04-27. PMID:21085657. |
in this study, we have investigated whether human embryonic stem cell-derived neurons could be a good model to study human tau distribution, function and dysfunction. |
2011-04-27 |
2023-08-12 |
human |