| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S Baliga, Sarah L Trinder, Emma Cook, Shiwen Xu, Adrian Hobbs, Christopher P Denton, David J Abraham, Markella Pontico. NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension. JCI insight. 2024-04-23. PMID:38652537. |
conversely, overexpression of nkx2-5 suppressed the expression of contractile genes (acta2, tagln, cnn1) and enhanced the expression of matrix genes (col1) in vascular smooth muscle cells. |
2024-04-23 |
2024-04-26 |
mouse |
| Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S Baliga, Sarah L Trinder, Emma Cook, Shiwen Xu, Adrian Hobbs, Christopher P Denton, David J Abraham, Markella Pontico. NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension. JCI insight. 2024-04-23. PMID:38652537. |
suppression of nkx2-5 expression in smooth muscle cells, halted vascular smooth muscle proliferation and migration, enhanced contractility and blocked the expression of the extracellular matrix genes. |
2024-04-23 |
2024-04-26 |
mouse |
| Paul Disse, Isabel Aymanns, Lena Mücher, Sarah Sandmann, Julian Varghese, Nadine Ritter, Nathalie Strutz-Seebohm, Guiscard Seebohm, Stefan Peischar. Knockout of the Cardiac Transcription Factor NKX2-5 Results in Stem Cell-Derived Cardiac Cells with Typical Purkinje Cell-like Signal Transduction and Extracellular Matrix Formation. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37686171. |
knockout of the cardiac transcription factor nkx2-5 results in stem cell-derived cardiac cells with typical purkinje cell-like signal transduction and extracellular matrix formation. |
2023-09-09 |
2023-10-07 |
human |
| Edwin G Peña-Martínez, Alejandro Rivera-Madera, Diego A Pomales-Matos, Leandro Sanabria-Alberto, Brittany M Rosario-Cañuelas, Jessica M Rodríguez-Ríos, Emanuel A Carrasquillo-Dones, José A Rodríguez-Martíne. Disease-associated non-coding variants alter NKX2-5 DNA-binding affinity. Biochimica et biophysica acta. Gene regulatory mechanisms. 2023-01-23. PMID:36690178. |
to address this challenge, we identified 8475 snps predicted to alter nkx2-5 dna-binding using a position weight matrix (pwm)-based predictive model. |
2023-01-23 |
2023-08-14 |
human |