| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S Baliga, Sarah L Trinder, Emma Cook, Shiwen Xu, Adrian Hobbs, Christopher P Denton, David J Abraham, Markella Pontico. NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension. JCI insight. 2024-04-23. PMID:38652537. |
conversely, overexpression of nkx2-5 suppressed the expression of contractile genes (acta2, tagln, cnn1) and enhanced the expression of matrix genes (col1) in vascular smooth muscle cells. |
2024-04-23 |
2024-04-26 |
mouse |
| Yinan Li, Xiu Huang, Jing Jin, Haohao Zhang, Kai Yang, Jingxia Han, Ying Lv, Yu Sun, Cheng Yao, Tingting Lin, Caibin Zhu, Huijuan Li. Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging. Cell & bioscience. vol 13. issue 1. 2023-05-06. PMID:37149635. |
this work found that uva irradiation caused an imbalance between dermal matrix synthesis and degradation through the aberrant upregulation of transgelin (tagln) and studied the underlying molecular mechanism. |
2023-05-06 |
2023-08-14 |
Not clear |
| Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luiz Felipe Pinho Moreira, Martin Conrad Harmse. Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30413733. |
fgf-2 blocked the differentiation, as evidenced by the reduction in gene (tagln, p < 0.0001; acta2, p = 0.0056) and protein (αsma, p = 0.0338) expression of mesenchymal markers and extracellular matrix components gene expression (col1a1, p < 0.0001; col3a1, p = 0.0029). |
2019-11-25 |
2023-08-13 |
human |
| Antonia P Popova, Paul D Bozyk, Adam M Goldsmith, Marisa J Linn, Jing Lei, J Kelley Bentley, Marc B Hershenso. Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. American journal of physiology. Lung cellular and molecular physiology. vol 298. issue 6. 2010-06-14. PMID:20190033. |
treatment of mscs with tgf-beta1 further induced the expression of mrnas encoding contractile (acta2, myh11, tagln, des) and extracellular matrix proteins (fn1, eln, col1a1, col1a2), and increased the protein expression of alpha-smooth muscle actin, myosin heavy chain, and sm22. |
2010-06-14 |
2023-08-12 |
human |
| Antonia P Popova, Paul D Bozyk, Adam M Goldsmith, Marisa J Linn, Jing Lei, J Kelley Bentley, Marc B Hershenso. Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. American journal of physiology. Lung cellular and molecular physiology. vol 298. issue 6. 2010-06-14. PMID:20190033. |
unstimulated mscs expressed mrnas encoding contractile (e.g., acta2, tagln), extracellular matrix (col1a1 and eln), and actin-binding (dbn1, pxn) proteins, consistent with a myofibroblast phenotype, although there was little translation into immunoreactive protein. |
2010-06-14 |
2023-08-12 |
human |
| Sean M Garvey, Daniel S Sinden, Pamela D Schoppee Bortz, Brian R Wamhof. Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo. The Journal of pharmacology and experimental therapeutics. vol 333. issue 1. 2010-04-22. PMID:20089806. |
we show that the vsmc differentiation marker genes smooth muscle alpha-actin (acta2), transgelin (tagln), smoothelin (smtn), and myocardin (myocd) are all down-regulated by csa in vsmc monoculture, whereas cyclin-dependent kinase inhibitor-1a (cdkn1a) and matrix metalloproteinase-3 (mmp3) are up-regulated. |
2010-04-22 |
2023-08-12 |
rat |
| Gerold Untergasser, Roland Gander, Claudia Lilg, Günter Lepperdinger, Eugen Plas, Peter Berge. Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation. Mechanisms of ageing and development. vol 126. issue 1. 2005-06-16. PMID:15610763. |
genes specifically up-regulated by transdifferentiation but not by cellular senescence of prscs were metalloproteinase 1 tissue inhibitor (timp1), transgelin (tagln), gamma 2 actin (actg2), plasminogen activator inhibitor 1 (serpinel), insulin-like growth factor binding protein 3 (igfbp3), parathyroid hormone-like hormone (pthlp), tgfb-1, four and a half lim domains 2 (fhl-2), hydrogen peroxide-inducible clone 5 (hic5) and cartilage oligomeric matrix protein (comp). |
2005-06-16 |
2023-08-12 |
human |