| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Waicong Dai, Mengsi Zhan, Yue Gao, Huxiao Sun, Yu Zou, Régis Laurent, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen, Xiangyang Sh. Brain delivery of fibronectin through bioactive phosphorous dendrimers for Parkinson's disease treatment via cooperative modulation of microglia. Bioactive materials. vol 38. 2024-05-03. PMID:38699237. |
with the abundant dendrimer surface hydroxyl terminal groups, the developed ncs are able to cross blood-brain barrier (bbb) to exert targeted therapy of a pd mouse model through the ak123-mediated anti-inflammation for m2 polarization of microglia and fn-mediated antioxidant and anti-inflammatory effects, thus reducing the aggregation of α-synuclein and restoring the contents of dopamine and tyrosine hydroxylase to normal levels |
2024-05-03 |
2024-05-05 |
mouse |
| Lili Ma, Na Mi, Zhi Wang, Rui Bao, Jing Fang, Yajing Ren, Xiuzhi Xu, Hongjia Zhang, Ying Tan. Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease. Journal of chemical neuroanatomy. 2024-04-26. PMID:38670441. |
irf8 was found to be prominently expressed in the substantia nigra pars compacta (snpc) region of pd mice and lps-stimulated bv2 cells, while the expression of tyrosine hydroxylase (th) and dopamine (da) content in the snpc region of pd mice was notably reduced. |
2024-04-26 |
2024-04-29 |
mouse |
| Jia-Yi Yao, Lu Li, Ji-Xuan Xu, Yan-Hong Liu, Jing Shi, Xiao-Qi Yu, Qing-Quan Kong, Kun L. Real-Time Monitoring of Tyrosine Hydroxylase Activity with a Ratiometric Fluorescent Probe. Analytical chemistry. 2024-04-23. PMID:38652135. |
tyrosine hydroxylase (th) is a key enzyme for producing dopamine, the levels of which can serve as an indicator for assessing the severity and progression of pd. |
2024-04-23 |
2024-04-26 |
Not clear |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Guoqian Liu, Mengwei Li, Zimei Zeng, Qi Fan, Xinxin Ren, Zhexin Wang, Yaoqi Sun, Yulin He, Lunquan Sun, Yuezhen Deng, Shupeng Liu, Chenxi Zhong, Jie Ga. Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling. European journal of medical research. vol 29. issue 1. 2024-04-12. PMID:38610044. |
this research demonstrated that tyrosine hydroxylase (th), which responsible for the initial and limiting step in the bio-generation of the neuro-transmitters dopamine and adrenaline, et al. |
2024-04-12 |
2024-04-15 |
Not clear |
| Cui Liu, Wen-Hong Liu, Wu Yang, Lei Chen, Yan Xue, Xin-Yi Che. GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice. Neuropharmacology. 2024-04-10. PMID:38599494. |
the spontaneous firing activity of nigral dopaminergic neurons is associated with some important roles including modulation of dopamine release, expression of tyrosine hydroxylase (th), as well as neuronal survival. |
2024-04-10 |
2024-04-13 |
mouse |
| Isabel Soto, Robert McManus, Walter Navarrete-Barahona, Ella A Kasanga, Kirby Doshier, Vicki A Nejtek, Michael F Salvator. Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. Experimental neurology. 2024-04-05. PMID:38580154. |
aging hastens locomotor decline in pink1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. |
2024-04-05 |
2024-04-10 |
human |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor. Brain research. 2024-03-30. PMID:38554797. |
this restoration was achieved through the upregulation of dopamine d3r and increase of tyrosine hydroxylase (th) expression, as well as boosting dopamine levels. |
2024-03-30 |
2024-04-02 |
rat |
| Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot, Adam MacDonald, Moein Yaqubi, Samantha Gruenheid, Louis-Eric Trudeau, Jo Anne Stratto. Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. The European journal of neuroscience. 2024-03-15. PMID:38487941. |
most investigations relating to enteric dopamine (da) neurons rely on immunoreactivity to tyrosine hydroxylase (th)-the rate-limiting enzyme in the production of da. |
2024-03-15 |
2024-03-17 |
mouse |
| Nicolas C Galinelli, Nicholas J Bamford, Melody A de Laat, Martin N Sillence, Patricia A Harris, Simon R Baile. Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas. PloS one. vol 19. issue 2. 2024-02-27. PMID:38412155. |
immunohistochemistry was performed to identify tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine production, and dopamine d2 receptors in tissue sections. |
2024-02-27 |
2024-03-01 |
Not clear |
| Yuanwen Peng, Cui Wang, Wei Ma, Qianhui Chen, Guannan Xu, Ying Kong, Li Ma, Wenyong Ding, Wenli Zhan. Deficiency of polypeptide N-acetylgalactosamine transferase 9 contributes to a risk for Parkinson's disease via mitochondrial dysfunctions. International journal of biological macromolecules. 2024-02-24. PMID:38401583. |
galnt9 silencing contributed to a causative factor in pd pathogenesis via reducing the levels of intracellular dopamine, tyrosine hydroxylase and soluble α-synuclein, and promoting α-synuclein aggregates. |
2024-02-24 |
2024-02-27 |
mouse |
| Vitaly Ryu, Anisa Gumerova, Ronit Witztum, Funda Korkmaz, Hasni Kannangara, Ofer Moldavski, Orly Barak, Daria Lizneva, Ki A Goosens, Sarah Stanley, Se-Min Kim, Tony Yuen, Mone Zaid. An Atlas of Brain-Bone Sympathetic Neural Circuits. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370676. |
histological studies show abundant sns innervation of the periosteum and bone marrow--these nerves consist of noradrenergic fibers that immunostain for tyrosine hydroxylase, dopamine beta hydroxylase, or neuropeptide y. |
2024-02-19 |
2024-02-21 |
Not clear |
| Isabel Soto, Robert McManus, Walter Navarrete-Barahona, Ella A Kasanga, Kirby Doshier, Vicki A Nejtek, Michael F Salvator. Aging hastens locomotor decline in PINK1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352365. |
aging hastens locomotor decline in pink1 knockout rats in association with decreased nigral, but not striatal, dopamine and tyrosine hydroxylase expression. |
2024-02-14 |
2024-02-16 |
human |
| Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A Pieper, Nandakumar S Narayana. Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits. eNeuro. vol 11. issue 2. 2024-02-13. PMID:38351057. |
it has been reported that hemizygous transgenic mice with tyrosine hydroxylase promotor-driven expression of a53t/a30p mutant alpha-synuclein in dopamine neurons provide a useful preclinical model of these conditions by virtue of developing behavioral deficits. |
2024-02-13 |
2024-02-16 |
mouse |
| Cameron Keomanivong, Josephine Schamp, Ervina Tabakovic, Ramasamy Thangavel, Georgina Aldridge, Andrew A Pieper, Nandakumar S Narayana. Mice Expressing A53T/A30P Mutant Alpha-Synuclein in Dopamine Neurons Do Not Display Behavioral Deficits. eNeuro. vol 11. issue 2. 2024-02-13. PMID:38351057. |
despite detecting robust overexpression of a53t/a30p mutant alpha-synuclein in dopamine neurons, we did not observe decreased tyrosine hydroxylase immunofluorescence or behavioral deficits in these mice. |
2024-02-13 |
2024-02-16 |
mouse |
| Yoshiaki Soejima, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yasuhiro Nakano, Fumio Otsuk. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338864. |
orexin a treatment reduced the mrna levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (th), 3,4-dihydroxyphenylalanie decarboxylase (ddc) and dopamine β-hydroxylase (dbh), in a concentration-dependent manner. |
2024-02-10 |
2024-02-12 |
rat |
| Yeqing Xu, Jun Nie, Chenghao Lu, Chao Hu, Yunlu Chen, Ying Ma, Yuru Huang, Liping L. Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review. The Science of the total environment. 2024-02-07. PMID:38325473. |
this study provides an overview of the underlying pathogenic molecular mechanisms as a valuable basis for understanding neurodegenerative disease responses to bps, including accumulation of misfolded proteins, reduction of tyrosine hydroxylase and dopamine, abnormal hormone signaling, neuronal death, oxidative stress, calcium homeostasis, and inflammation. |
2024-02-07 |
2024-02-10 |
human |
| Raman Kumar Tripathi, Lav Goyal, Shamsher Sing. Potential Therapeutic Approach Using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson's Disease. Current gene therapy. 2024-02-04. PMID:38310455. |
enhancing the enzymatic activity of tyrosine hydroxylase (th), glucocorticoid hormone (gch), and aadc in the striatum would be useful for external l-dopa to restore the dopamine (da) level. |
2024-02-04 |
2024-02-06 |
Not clear |
| Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Michael Ugrumo. Initial Molecular Mechanisms of the Pathogenesis of Parkinson's Disease in a Mouse Neurotoxic Model of the Earliest Preclinical Stage of This Disease. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279354. |
it was shown that the content of tyrosine hydroxylase (th), the first enzyme in dopamine synthesis, does not change within 6 h after the administration of mptp, but decreases after 24 h. in turn, th activity increases after 1 h, decreases after 3 h, remains at the control level after 6 h, and decreases 24 h after the administration of mptp. |
2024-01-27 |
2024-01-29 |
mouse |