| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Wang, Feng Gao, Shuai Cui, Shaojie Yang, Fang Gao, Xuncui Wang, Guoqi Zh. Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD. Pharmacological research. 2022-01-13. PMID:35026406. |
from the perspective of synaptic function, the sps&s model displayed reduced expression of bdnf, p-trkb, postsynaptic density protein 95 (psd95), ampa receptor subunit glur1 (glua1), nmda receptor subunit n2a/n2b ratio, calpain-1, phosphorylated protein kinase b (akt) and phosphorylated mammalian target of rapamycin (mtor) and conversely, higher phosphatase and tension homolog (pten) expression in the hippocampus. |
2022-01-13 |
2023-08-13 |
mouse |
| Alberto Marcos, Inmaculada Ballesteros-Yáñez, Carlos A Castillo-Sarmiento, Felipe Pardo, David Roura-Martínez, José Ramón Muñoz-Rodríguez, Alejandro Higuera-Matas, Emilio Ambrosi. The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Neuropharmacology. 2021-12-29. PMID:34965406. |
brain samples from the medial prefrontal cortex, nucleus accumbens, hippocampus and amygdala were extracted to analyse the mrna expression of genes encoding subunits of the gaba, nmda and ampa receptors, as well as the expression of the cb1 receptor, and that of enzymes related to the biosynthesis and degradation of endocannabinoids. |
2021-12-29 |
2023-08-13 |
rat |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
importantly, our data demonstrated strongly enhanced expression of nlrp3, asc and caspase-1 in the hippocampus of aged rats as well as decreased ampa receptor and phosphorylated levels of camkii and creb in the hippocampus of natural aging rats. |
2021-12-11 |
2023-08-13 |
rat |
| Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yua. Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity. Neurochemistry international. vol 152. 2021-12-11. PMID:34743016. |
furthermore, nlrp3 inflammasome inhibitor elevated the surface expression of ampa receptor and the phosphorylated levels of camkii, creb in hippocampus, and finally contributed to the attenuation of hippocampal long-term potentiation (ltp) deficits and the improvement of cognitive decline of natural aging rats. |
2021-12-11 |
2023-08-13 |
rat |
| Jie Yu, Prashant Rao, Sarah Clark, Jaba Mitra, Taekjip Ha, Eric Gouau. Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature. vol 594. issue 7863. 2021-12-03. PMID:33981040. |
hippocampal ampa receptor assemblies and mechanism of allosteric inhibition. |
2021-12-03 |
2023-08-13 |
Not clear |
| Mohammed E A Elhussiny, Giulia Carini, Jessica Mingardi, Paolo Tornese, Nathalie Sala, Federica Bono, Chiara Fiorentini, Luca La Via, Maurizio Popoli, Laura Musazzi, Alessandro Barbo. Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-29. PMID:32640261. |
using the chronic mild stress (cms) rat model of depression, performed in male rats, we aimed at analyzing whether hippocampal specific changes in subunit expression and regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) or nmda ionotropic receptors and in metabotropic glutamate receptors could be associated with behavioral vulnerability/resilience to cms. |
2021-11-29 |
2023-08-13 |
rat |
| Xin Qin, Michael G Zaki, Zhicheng Chen, Elisabet Jakova, Zhi Ming, Francisco S Cayabya. Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2. Molecular neurobiology. vol 58. issue 5. 2021-11-19. PMID:33415682. |
adenosine signaling and clathrin-mediated endocytosis of glutamate ampa receptors in delayed hypoxic injury in rat hippocampus: role of casein kinase 2. |
2021-11-19 |
2023-08-13 |
rat |
| Carlos O Oueslati Morales, Attila Ignácz, Norbert Bencsik, Zsofia Sziber, Anikó Erika Rátkai, Wolfgang S Lieb, Stephan A Eisler, Attila Szűcs, Katalin Schlett, Angelika Hausse. Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic (Copenhagen, Denmark). vol 22. issue 12. 2021-11-19. PMID:34564930. |
protein kinase d promotes activity-dependent ampa receptor endocytosis in hippocampal neurons. |
2021-11-19 |
2023-08-13 |
Not clear |
| Hannah E Frye, Yukitoshi Izumi, Alexis N Harris, Sidney B Williams, Christopher R Trousdale, Min-Yu Sun, Andrew D Sauerbeck, Terrance T Kummer, Steven Mennerick, Charles F Zorumski, Elliot C Nelson, Joseph D Dougherty, Jose A Moró. Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity. Biological psychiatry. vol 90. issue 11. 2021-11-18. PMID:34548146. |
cnih3 is an ampa receptor (ampar) auxiliary protein prominently expressed in the dorsal hippocampus (dhpc), a region that plays a critical role in spatial memory and synaptic plasticity. |
2021-11-18 |
2023-08-13 |
Not clear |
| Wei Sun, Xiaoliang Li, Dongxin Tang, Yuanhua Wu, Lei A. Subacute melamine exposure disrupts task-based hippocampal information flow via inhibiting the subunits 2 and 3 of AMPA glutamate receptors expression. Human & experimental toxicology. vol 40. issue 6. 2021-11-15. PMID:33243008. |
subacute melamine exposure disrupts task-based hippocampal information flow via inhibiting the subunits 2 and 3 of ampa glutamate receptors expression. |
2021-11-15 |
2023-08-13 |
rat |
| Longfei Cheng, Keen Chen, Jiong Li, Jiaming Wu, Jiaqi Zhang, Li Chen, Guoqing Guo, Jifeng Zhan. Phosphorylation of CRMP2 by Cdk5 Negatively Regulates the Surface Delivery and Synaptic Function of AMPA Receptors. Molecular neurobiology. 2021-11-13. PMID:34773219. |
here, we reported that crmp2 promoted the surface expression of ampa receptor glua1 subunit in cultured hippocampal neurons and in hek293t cells expressing glua1 subunits. |
2021-11-13 |
2023-08-13 |
Not clear |
| Longfei Cheng, Keen Chen, Jiong Li, Jiaming Wu, Jiaqi Zhang, Li Chen, Guoqing Guo, Jifeng Zhan. Phosphorylation of CRMP2 by Cdk5 Negatively Regulates the Surface Delivery and Synaptic Function of AMPA Receptors. Molecular neurobiology. 2021-11-13. PMID:34773219. |
moreover, our results showed that phosphorylation of crmp2 at ser522 by cyclin-dependent kinase 5 (cdk5) decreased the fluorescence intensity of surface glua1 and the amplitude and frequency of miniature excitatory synaptic currents (mepscs) in cultured hippocampal neurons, indicating a reduction levels and synaptic function of ampa receptors. |
2021-11-13 |
2023-08-13 |
Not clear |
| Longfei Cheng, Keen Chen, Jiong Li, Jiaming Wu, Jiaqi Zhang, Li Chen, Guoqing Guo, Jifeng Zhan. Phosphorylation of CRMP2 by Cdk5 Negatively Regulates the Surface Delivery and Synaptic Function of AMPA Receptors. Molecular neurobiology. 2021-11-13. PMID:34773219. |
taken together, our data demonstrated that phosphorylation of crmp2 by cdk5 is important for ampa receptor surface delivery in hippocampal neurons. |
2021-11-13 |
2023-08-13 |
Not clear |
| Ellen G Fraser, Ty Makarowski, Robert J McDonal. Perforant path inputs to hippocampal subfields predict heterogeneous AMPA receptor subunit expression following rapid new spatial learning in a novel context. The European journal of neuroscience. vol 54. issue 8. 2021-11-03. PMID:34214189. |
perforant path inputs to hippocampal subfields predict heterogeneous ampa receptor subunit expression following rapid new spatial learning in a novel context. |
2021-11-03 |
2023-08-13 |
rat |
| Ellen G Fraser, Ty Makarowski, Robert J McDonal. Perforant path inputs to hippocampal subfields predict heterogeneous AMPA receptor subunit expression following rapid new spatial learning in a novel context. The European journal of neuroscience. vol 54. issue 8. 2021-11-03. PMID:34214189. |
the present experiment measures ampa subunit expression, in a ratio of glua2:glua1 as an indicator of plasticity across the hippocampus, in rats that underwent new spatial learning in either a familiar or novel context. |
2021-11-03 |
2023-08-13 |
rat |
| Shinji Matsuda, Michisuke Yuzak. Subunit-dependent and subunit-independent rules of AMPA receptor trafficking during chemical long-term depression in hippocampal neurons. The Journal of biological chemistry. vol 297. issue 2. 2021-11-03. PMID:34252460. |
subunit-dependent and subunit-independent rules of ampa receptor trafficking during chemical long-term depression in hippocampal neurons. |
2021-11-03 |
2023-08-13 |
Not clear |
| Maryam Mahmoodkhani, Maedeh Ghasemi, Leila Derafshpour, Mohammad Amini, Nasrin Mehranfar. Long-Term Decreases in the Expression of Calcineurin and GABAA Receptors Induced by Early Maternal Separation Are Associated with Increased Anxiety-Like Behavior in Adult Male Rats. Developmental neuroscience. vol 42. issue 2-4. 2021-10-26. PMID:33341802. |
here, we investigated the effect of early life stress, such as repeated maternal separation (ms; 3 h per day from postnatal day [p] 2 to 11), on changes in the expression of calcineurin as well as the ionotropic glutamatergic and gabaergic receptors including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), n-methyl-d-aspartate (nmda) and gabaa receptors in the hippocampus and prefrontal cortex (pfc) of adolescent (p35) and adult (p62) male wistar rats and their correlations with anxiety-like behavior in adulthood. |
2021-10-26 |
2023-08-13 |
rat |
| Jennifer L Sanderson, Ronald K Freund, Jessica A Gorski, Mark L Dell'Acqu. β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca Cell reports. vol 37. issue 1. 2021-10-23. PMID:34610314. |
β-amyloid disruption of ltp/ltd balance is mediated by akap150-anchored pka and calcineurin regulation of ca regulated insertion and removal of postsynaptic ampa glutamate receptors (ampars) mediates hippocampal long-term potentiation (ltp) and long-term depression (ltd) synaptic plasticity underlying learning and memory. |
2021-10-23 |
2023-08-13 |
Not clear |
| Collin J Preston, John J Wagne. Withdrawal from cocaine conditioning progressively alters AMPA receptor-mediated transmission in the ventral hippocampus. Addiction biology. 2021-10-23. PMID:34687119. |
withdrawal from cocaine conditioning progressively alters ampa receptor-mediated transmission in the ventral hippocampus. |
2021-10-23 |
2023-08-13 |
Not clear |
| Niccolò P Pampaloni, Andrew J R Pleste. Slow excitatory synaptic currents generated by AMPA receptors. The Journal of physiology. 2021-10-21. PMID:34587649. |
further, slow ampa currents span 'cognitive' time intervals in the 100 ms range (theta rhythms), of particular interest for hippocampal function, where slow ampa currents are widely expressed in a synapse-specific manner. |
2021-10-21 |
2023-08-13 |
Not clear |