| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alaa Khayat, Rami Yak. Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system. Frontiers in molecular neuroscience. vol 17. 2024-03-26. PMID:38528956. |
furthermore, optic stimulation of nac-vta inputs during cocaine exposure decreased the expression of glua1 subunit of ampa receptor in the vta and mpfc. |
2024-03-26 |
2024-03-28 |
Not clear |
| A Khayat, R Yak. Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system. Translational psychiatry. vol 14. issue 1. 2024-01-19. PMID:38242878. |
specifically, we found that cocaine-induced alteration in the phosphorylation state of erk (perk) and glua1 on serine 845 (s845) and serine 831 (s831), that play a major role in plasticity by controlling the activity and trafficking of ampa receptors, were significantly reversed following optic stimulation of rmtg afferents to the vta. |
2024-01-19 |
2024-01-22 |
Not clear |
| Louisa E Linders, Lefkothea Patrikiou, Mariano Soiza-Reilly, Evelien H S Schut, Bram F van Schaffelaar, Leonard Böger, Inge G Wolterink-Donselaar, Mieneke C M Luijendijk, Roger A H Adan, Frank J Mey. Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food. Nature communications. vol 13. issue 1. 2022-11-12. PMID:36371405. |
specifically, we show that glutamatergic lha neurons projecting to the vta are activated by social stress, after which their synapses onto dopamine neurons are potentiated via ampa receptor subunit alterations. |
2022-11-12 |
2023-08-14 |
mouse |
| Maria-Carmen Medrano, Imane Hurel, Emma Mesguich, Bastien Redon, Christopher Stevens, François Georges, Miriam Melis, Giovanni Marsicano, Francis Chaoulof. Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons. Addiction biology. vol 26. issue 3. 2021-11-01. PMID:33021007. |
exercise might thus share with drugs the ability to strengthen excitatory synapses onto ventral tegmental area (vta) dopaminergic neurones, as assessed by the ratio of ampa receptor (ampar)-mediated excitatory postsynaptic currents (epscs) to nmda receptor (nmdar)-mediated epscs. |
2021-11-01 |
2023-08-13 |
Not clear |
| Olga Skiteva, Ning Yao, Karima Chergu. Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34650029. |
we have examined if ketamine alters the insertion of the glua2 subunit of ampa receptors (ampar), which determines calcium permeability of the channel, at glutamatergic synapses onto dopamine (da) neurons in the vta and spiny projection neurons (spns) in the core region of the nac. |
2021-10-21 |
2023-08-13 |
mouse |
| Olga Skiteva, Ning Yao, Karima Chergu. Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34650029. |
ketamine induces opposite changes in ampa receptor calcium permeability in the ventral tegmental area and nucleus accumbens. |
2021-10-21 |
2023-08-13 |
mouse |
| Thiago C Moulin, Helgi B Schiöt. Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure. Behavioral and brain functions : BBF. vol 16. issue 1. 2021-09-02. PMID:32522229. |
glutamatergic ampa and nmda receptors in the ventral tegmental area (vta) are central for cocaine first exposure and posterior craving maintenance. |
2021-09-02 |
2023-08-13 |
Not clear |
| Suraj B Teegala, Zhenyu Sheng, Miloni S Dalal, Pamela R Hirschberg, Kevin D Beck, Vanessa H Rout. Lateral hypothalamic orexin glucose-inhibited neurons may regulate reward-based feeding by modulating glutamate transmission in the ventral tegmental area. Brain research. vol 1731. 2021-06-07. PMID:29787770. |
n-methyl-d-aspartate (nmda) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) currents on putative vta da neurons were measured using whole cell voltage clamp recording in horizontal brain slices containing the lh and vta. |
2021-06-07 |
2023-08-13 |
Not clear |
| Megan L Rudolph, Racheal L Neve, Ronald P Hammer, Ella M Nikulin. Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats. The European journal of neuroscience. 2020-07-14. PMID:32594591. |
our recent data reveal heightened expression of ampa receptor (ampar) glua1 subunit in rat ventral tegmental area (vta), which occurs concurrently with social stress-induced amphetamine (amph) cross-sensitization. |
2020-07-14 |
2023-08-13 |
human |
| Megan L Rudolph, Racheal L Neve, Ronald P Hammer, Ella M Nikulin. Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats. The European journal of neuroscience. 2020-07-14. PMID:32594591. |
enhanced psychostimulant response, but not social avoidance, depends on glua1 ampa receptors in vta dopamine neurons following intermittent social defeat stress in rats. |
2020-07-14 |
2023-08-13 |
human |
| Asal Keramatian, Hojjatallah Alaei, Akram Eidi, Maryam Radahmad. Electrical stimulation mPFC affects morphine addiction by changing glutamate concentration in the ventral tegmental area. Metabolic brain disease. vol 34. issue 4. 2020-04-30. PMID:31115726. |
this was performed after electrical stimulation and inducing lesion of mpfc and through microinjections of n-methyl-d-aspartate (nmda) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor antagonists, respectively ap5 and cnqx, into the vta of addicted rats. |
2020-04-30 |
2023-08-13 |
rat |
| Theis H Ipsen, Filip S Polli, Kristi A Kohlmeie. Calcium rises induced by AMPA and nicotine receptors in the ventral tegmental area show differences in mouse brain slices prenatally exposed to nicotine. Developmental neurobiology. 2019-11-20. PMID:29923678. |
we found that ampa induced smaller amplitude calcium rises in the pne vta, which was an effect only detected in males. |
2019-11-20 |
2023-08-13 |
mouse |
| Theis H Ipsen, Filip S Polli, Kristi A Kohlmeie. Calcium rises induced by AMPA and nicotine receptors in the ventral tegmental area show differences in mouse brain slices prenatally exposed to nicotine. Developmental neurobiology. 2019-11-20. PMID:29923678. |
calcium rises induced by ampa and nicotine receptors in the ventral tegmental area show differences in mouse brain slices prenatally exposed to nicotine. |
2019-11-20 |
2023-08-13 |
mouse |
| Theis H Ipsen, Filip S Polli, Kristi A Kohlmeie. Calcium rises induced by AMPA and nicotine receptors in the ventral tegmental area show differences in mouse brain slices prenatally exposed to nicotine. Developmental neurobiology. 2019-11-20. PMID:29923678. |
accordingly, in vta brain slices from male and female mice exposed to nicotine during the prenatal period (pne) and controls, we compared cellular rises in calcium induced by ampa receptor and nicotinic acetylcholine receptor (nachr) stimulation by use of the ratiometric calcium binding dye, fura-2am. |
2019-11-20 |
2023-08-13 |
mouse |
| Daniel Guzman, Maria B Carreira, Allyson K Friedman, Megumi Adachi, Rachael L Neve, Lisa M Monteggia, Ming-Hu Han, Christopher W Cowan, David W Sel. Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 3. 2019-02-28. PMID:29196318. |
despite blocking tissue glua1 increases in cocaine self-administering animals, the hsv-dnglun1 treatment resulted in increased membrane levels of glua1 and glun2b, along with markedly higher locomotor responses to intra-vta infusions of ampa, suggesting a paradoxical increase in vta ampa receptor responsiveness. |
2019-02-28 |
2023-08-13 |
rat |
| Daniel Guzman, Maria B Carreira, Allyson K Friedman, Megumi Adachi, Rachael L Neve, Lisa M Monteggia, Ming-Hu Han, Christopher W Cowan, David W Sel. Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 3. 2019-02-28. PMID:29196318. |
together, these data suggest that nmdars mediate cocaine-induced increases in vta glua1 expression, but such transient nmdar inactivation also leads to compensatory scaling of synaptic ampa receptors that enhance the motivational for cocaine. |
2019-02-28 |
2023-08-13 |
rat |
| Sebastiano Bariselli, Hanna Hörnberg, Clément Prévost-Solié, Stefano Musardo, Laetitia Hatstatt-Burklé, Peter Scheiffele, Camilla Bellon. Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction. Nature communications. vol 9. issue 1. 2019-01-07. PMID:30093665. |
exploration of nonfamiliar stimuli is associated with the insertion of glua2-lacking ampa receptors at excitatory synapses on vta da neurons. |
2019-01-07 |
2023-08-13 |
mouse |
| Xiaojie Liu, Yao Chen, Jiaqing Tong, Ashley M Reynolds, Sarah C Proudfoot, Jinshun Qi, Peter Penzes, Youming Lu, Qing-Song Li. Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 17. 2017-06-19. PMID:27122037. |
epac signaling is required for cocaine-induced change in ampa receptor subunit composition in the ventral tegmental area. |
2017-06-19 |
2023-08-13 |
mouse |
| J M Witkin, J A Monn, D D Schoepp, X Li, C Overshiner, S N Mitchell, G Carter, B Johnson, K Rasmussen, L M Rorick-Keh. The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits. The Journal of pharmacology and experimental therapeutics. vol 358. issue 1. 2017-05-23. PMID:27189960. |
both the vta neuronal activation and the antidepressant phenotype induced by ketamine and ly341495 were attenuated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo- (9ci)-benzo[f]quinoxaline-7-sulfonamide, indicating ampa-dependent effects. |
2017-05-23 |
2023-08-13 |
mouse |
| Priscila Hachimine, Neal Seepersad, Sandra Babic, Robert Ranald. Concurrent antagonism of NMDA and AMPA receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats. Behavioural brain research. vol 298. issue Pt B. 2016-09-20. PMID:26542814. |
concurrent antagonism of nmda and ampa receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats. |
2016-09-20 |
2023-08-13 |
rat |