| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asuman Kaplan Algin, Canberk Tomruk, Çiğdem Gözde Aslan, Sinan Şaban Akkurt, Gülcihan Mehtap Çinar, Sezgin Ulukaya, Yiğit Uyanikgil, Yasemin Akça. Effects of ozone treatment to the levels of neurodegeneration biomarkers after rotenone induced rat model of Parkinson's disease. Neuroscience letters. 2023-08-19. PMID:37597740. |
α-synuclein, amyloid-β, tau, phosphorylated tau, as well as tyrosine hydroxylase(+), nnos(+), and glial cell counts were used to evaluate neurodegeneration in the substantia nigra pars compacta and ventral tegmental area. |
2023-08-19 |
2023-09-07 |
rat |
| Runan Sun, Mariko Sugiyama, Sixian Wang, Mitsuhiro Kuno, Tomoyuki Sasaki, Tomonori Hirose, Takashi Miyata, Tomoko Kobayashi, Taku Tsunekawa, Takeshi Onoue, Yoshinori Yasuda, Hiroshi Takagi, Daisuke Hagiwara, Shintaro Iwama, Hidetaka Suga, Hiroshi Arim. Inflammation in VTA Caused by HFD Induces Activation of Dopaminergic Neurons Accompanied by Binge-like Eating. Nutrients. vol 14. issue 18. 2022-09-23. PMID:36145208. |
thus, our data suggest that hfd-induced inflammation with glial cell activation in the vta affects dns function and causes abnormal eating behaviors accompanied by insulin resistance in the vta of female mice. |
2022-09-23 |
2023-08-14 |
mouse |
| Rianne R Campbell, Siwei Chen, Joy H Beardwood, Alberto J López, Lilyana V Pham, Ashley M Keiser, Jessica E Childs, Dina P Matheos, Vivek Swarup, Pierre Baldi, Marcelo A Woo. Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 10. 2021-08-27. PMID:34155331. |
these data indicate that cocaine alters networks enriched with glial cell markers of the vta that are involved in gene regulation and synaptic processes. |
2021-08-27 |
2023-08-13 |
mouse |
| Soledad Marton, Bruno González, Sebastián Rodríguez-Bottero, Ernesto Miquel, Laura Martínez-Palma, Mariana Pazos, José Pedro Prieto, Paola Rodríguez, Dalibor Sames, Gustavo Seoane, Cecilia Scorza, Patricia Cassina, Ignacio Carrer. Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30890941. |
recent work has suggested that ibogaine effects on alcohol self-administration in rats are related to the release of glial cell derived neurotrophic factor (gdnf) in the ventral tegmental area (vta), a mesencephalic region which hosts the soma of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
human |
| Ryota L Matsuoka, Andrea Rossi, Oliver A Stone, Didier Y R Stainie. CNS-resident progenitors direct the vascularization of neighboring tissues. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 38. 2018-06-05. PMID:28855341. |
importantly, vta formation is not affected by ablation of other cns cell types, and radial glia ablation also compromises the subsequent formation of the peri-neural vascular plexus (pnvp), a vascular network that surrounds the cns and is critical for cns angiogenesis. |
2018-06-05 |
2023-08-13 |
zebrafish |
| E M Nikulina, C E Johnston, J Wang, R P Hamme. Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse. Neuroscience. vol 282. 2018-01-26. PMID:24875178. |
this review discusses the impact of neurotrophins and other trophic factors, including fibroblast growth factor and glial cell line-derived neurotrophic factor, on mood disorders, weight regulation and drug abuse, with an emphasis on stress- and drug-induced changes in the ventral tegmental area (vta). |
2018-01-26 |
2023-08-13 |
mouse |
| Li Li, Junping Cao, Suming Zhang, Cunjin Wang, Jinfeng Wang, Ge Song, Hongjun Wang, Licai Zhan. NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations. Journal of molecular neuroscience : MN. vol 53. issue 4. 2015-04-06. PMID:24399412. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for midbrain dopamine (da) neurons, while the da neurons in the ventral tegmental area (vta) is a crucial part of the neural circuits associated with drug addiction. |
2015-04-06 |
2023-08-12 |
rat |
| Rongjun Zhang, Xinghui Cai, Xiaoge Song, Chaoyang Dong, Xiaorong Hou, Lei L. Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse. Neural regeneration research. vol 9. issue 3. 2014-09-10. PMID:25206816. |
immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. |
2014-09-10 |
2023-08-13 |
rat |
| Segev Barak, Sebastien Carnicella, Quinn V Yowell, Dorit Ro. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734280. |
we previously showed that infusion of glial cell line-derived neurotrophic factor (gdnf) into the ventral tegmental area (vta) rapidly reduces alcohol intake and relapse (carnicella et al., 2008, 2009a), and increases dopamine (da) levels in the nucleus accumbens (nac) of alcohol-naive rats (wang et al., 2010). |
2011-09-09 |
2023-08-12 |
rat |
| Mikko Airavaara, Charles L Pickens, Anna L Stern, Kristina A Wihbey, Brandon K Harvey, Jennifer M Bossert, Qing-Rong Liu, Barry J Hoffer, Yavin Shaha. Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving. Addiction biology. vol 16. issue 2. 2011-07-20. PMID:21182575. |
glial cell line-derived neurotrophic factor (gdnf) activity in ventral tegmental area (vta) mediates the time-dependent increases in cue-induced cocaine-seeking after withdrawal (incubation of cocaine craving). |
2011-07-20 |
2023-08-12 |
rat |
| A Chocyk, D Dudys, A Przyborowska, I Majcher, M Maćkowiak, K Wędzon. Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neuroscience. vol 173. 2011-04-20. PMID:21108994. |
it was found that ms decreased the total number of glia but not neuronal cells in the sn pars compacta (snc) and vta of males. |
2011-04-20 |
2023-08-12 |
rat |
| A Chocyk, D Dudys, A Przyborowska, I Majcher, M Maćkowiak, K Wędzon. Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neuroscience. vol 173. 2011-04-20. PMID:21108994. |
in summary, the results of the present study revealed that early life stress affects the number, proliferation and naturally occurring apoptosis of glia cells in the sn and vta in a sex-dependent manner and consequently may impair brain functions that are regulated by these structures. |
2011-04-20 |
2023-08-12 |
rat |
| Sebastien Carnicella, Dao-Yao He, Quinn V Yowell, Stanley D Glick, Dorit Ro. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. Addiction biology. vol 15. issue 4. 2011-02-28. PMID:21040239. |
previously, we reported that the desirable actions of ibogaine to reduce self-administration of, and relapse to, alcohol consumption are mediated via the upregulation of the expression of the glial cell line-derived neurotrophic factor (gdnf) in the midbrain ventral tegmental area (vta), and the consequent activation of the gdnf pathway. |
2011-02-28 |
2023-08-12 |
human |
| Jun Wang, Sebastien Carnicella, Somayeh Ahmadiantehrani, Dao-Yao He, Segev Barak, Viktor Kharazia, Sami Ben Hamida, Agustin Zapata, Toni S Shippenberg, Dorit Ro. Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 43. 2010-11-30. PMID:20980608. |
here we report that the glial cell line-derived neurotrophic factor (gdnf), produced in one target region, the nac, is retrogradely transported by da neurons to the vta where the growth factor positively regulates the spontaneous firing activity of both nac- and pfc-projecting da neurons in a mechanism that requires the activation of the mitogen-activated protein kinase (mapk) pathway. |
2010-11-30 |
2023-08-12 |
Not clear |
| Sebastien Carnicella, Somayeh Ahmadiantehrani, Patricia H Janak, Dorit Ro. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcoholism, clinical and experimental research. vol 33. issue 6. 2009-09-07. PMID:19302086. |
we previously found that activation of the glial cell line-derived neurotrophic factor (gdnf) pathway in the ventral tegmental area (vta) reduces ethanol-drinking behaviors. |
2009-09-07 |
2023-08-12 |
Not clear |
| Lin Lu, Xi Wang, Ping Wu, Chunmei Xu, Mei Zhao, Marisela Morales, Brandon K Harvey, Barry J Hoffer, Yavin Shaha. Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biological psychiatry. vol 66. issue 2. 2009-09-02. PMID:19345340. |
role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. |
2009-09-02 |
2023-08-12 |
Not clear |
| Sebastien Carnicella, Ryoji Amamoto, Dorit Ro. Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol (Fayetteville, N.Y.). vol 43. issue 1. 2009-04-10. PMID:19185208. |
we previously found that activation of the glial cell line-derived neurotrophic factor (gdnf) pathway in the ventral tegmental area (vta) reduces moderate alcohol (ethanol) intake in a rat operant self-administration paradigm. |
2009-04-10 |
2023-08-12 |
rat |
| Sebastien Carnicella, Viktor Kharazia, Jerome Jeanblanc, Patricia H Janak, Dorit Ro. GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 23. 2008-06-27. PMID:18541917. |
previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell line-derived neurotrophic factor (gdnf) in the ventral tegmental area (vta). |
2008-06-27 |
2023-08-12 |
rat |
| Dao-Yao He, Dorit Ro. Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18343820. |
we previously found that glial cell line-derived neurotrophic factor (gdnf) in the midbrain ventral tegmental area (vta) negatively regulates alcohol drinking (he, d. y., mcgough, n. n., ravindranathan, a., jeanblanc, j., logrip, m. l., phamluong, k., janak, p. h., and ron, d. (2005) j. neurosci. |
2008-06-17 |
2023-08-12 |
Not clear |
| A Lessard, E F Grady, N W Bunnett, V M Picke. Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area. Neuroscience. vol 144. issue 4. 2007-05-21. PMID:17197098. |
the activation of these receptors, together with the nk(3) receptors in either the presynaptic axon terminals or glia may contribute to the diverse physiological effects of tachykinins in each region, and most prominently involving excitatory inputs to the vta. |
2007-05-21 |
2023-08-12 |
rat |