| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jarek Wegiel, Kathryn Chadman, Eric London, Thomas Wisniewski, Jerzy Wegie. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. 2024-03-19. PMID:38500252. |
this review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, neuronal growth, differentiation, and arborization, as well as defective neuronal circuit formation in the cortex, subcortical structures, brainstem, and cerebellum of autistic subjects. |
2024-03-19 |
2024-03-21 |
human |
| Jarek Wegiel, Kathryn Chadman, Eric London, Thomas Wisniewski, Jerzy Wegie. Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. 2024-03-19. PMID:38500252. |
there is a discrepancy between more than 500 reports demonstrating the contribution of the serotonergic system to autism's behavioral anomalies, highlighted by lack of studies of autistic subjects' brainstem raphe nuclei, the center of brain serotonergic innervation, and of the contribution of the serotonergic system to the diagnostic features of autism spectrum disorder (asd). |
2024-03-19 |
2024-03-21 |
human |
| Bedia Samanci, Sonny Tan, Stijn Michielse, Mark L Kuijf, Yasin Teme. THE HABENULA IN PARKINSON'S DISEASE: ANATOMY, FUNCTION, AND IMPLICATIONS FOR MOOD DISORDERS - A NARRATIVE REVIEW. Journal of chemical neuroanatomy. 2024-01-18. PMID:38237746. |
degeneration of serotonergic neurons in brainstem raphe nuclei have been linked to depression and anxiety. |
2024-01-18 |
2024-01-21 |
Not clear |
| Ifat Israel-Elgali, Hope Pan, Keren Oved, Nir Pillar, Gilad Levy, Boaz Barak, Ana Carneiro, David Gurwitz, Noam Shomro. Impaired myelin ultrastructure is reversed by citalopram treatment in a mouse model for major depressive disorder. Journal of psychiatric research. vol 166. 2023-09-27. PMID:37757703. |
the raphe nuclei (rn), located in the brain stem, consist of clusters of serotonergic (5-ht) neurons that project to almost all regions of the brain. |
2023-09-27 |
2023-10-07 |
mouse |
| Nicolas Delestrée, Evangelia Semizoglou, John G Pagiazitis, Aleksandra Vukojicic, Estelle Drobac, Vasilissa Paushkin, George Z Menti. Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy. Brain : a journal of neurology. 2023-09-07. PMID:37678880. |
we also demonstrate that the 5-ht dysfunction is caused by smn deficiency in serotonergic neurons in the raphe nuclei of the brainstem. |
2023-09-07 |
2023-10-07 |
mouse |
| Simon Levinson, Michelle Miller, Ahmed Iftekhar, Monica Justo, Daniel Arriola, Wenxin Wei, Saman Hazany, Josue M Avecillas-Chasin, Taylor P Kuhn, Andreas Horn, Ausaf A Bar. A structural connectivity atlas of limbic brainstem nuclei. Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555163. |
several brainstem nuclei have been identified as the primary central nervous system (cns) source of important monoaminergic ascending fibers including the noradrenergic locus coeruleus, serotonergic dorsal raphe nucleus, and dopaminergic ventral tegmental area. |
2023-08-09 |
2023-08-16 |
Not clear |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Koichi J Homma, Shinji Yamaguch. Molecular biology of serotonergic systems in avian brains. Frontiers in molecular neuroscience. vol 16. 2023-08-04. PMID:37538316. |
in the central serotonergic system of vertebrate species examined so far, serotonergic neurons have been confirmed to exist in clusters in the brainstem. |
2023-08-04 |
2023-08-14 |
chicken |
| Arman Hajikarim-Hamedani, Amirhossein Heidari, Mitra-Sadat Sadat-Shirazi, Sarah Mahboubi, Samira Raminfard, Solmaz Khalifeh, Mohammad-Reza Zarrindas. The role of lateral habenula NMDA receptors in tramadol-induced conditioning. Behavioural pharmacology. 2023-07-04. PMID:37401401. |
the role of the lateral habenula (lhb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic regions in the brainstem makes this area a critical region in the control of reward and addiction. |
2023-07-04 |
2023-08-14 |
rat |
| Kanza M Khan, Nagalakshmi Balasubramanian, Gabriel Gaudencio, Ruixiang Wang, Govindhasamy Pushpavathi Selvakumar, Louis Kolling, Samantha Pierson, Satya M Tadinada, Ted Abel, Marco Hefti, Catherine A Marcinkiewc. Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer's disease. Acta neuropathologica communications. vol 11. issue 1. 2023-04-03. PMID:37009893. |
in total, these results suggest that tau pathology in brainstem monoaminergic nuclei and the resulting loss of serotonergic and/or noradrenergic drive may underpin depressive- and anxiety-like behaviors in the early stages of ad. |
2023-04-03 |
2023-08-14 |
mouse |
| Carl L Faingold, Hua-Jun Fen. A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray. Epilepsia. 2023-01-30. PMID:36715572. |
this effect of serotonergic drugs may be mediated, in part, by actions on brainstem sites that modulate respiration, including the pag. |
2023-01-30 |
2023-08-14 |
human |
| Carl L Faingold, Hua-Jun Fen. A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray. Epilepsia. 2023-01-30. PMID:36715572. |
therefore, we hypothesize that serotonergic or direct activation of this brainstem site may be a useful approach for sudep prevention. |
2023-01-30 |
2023-08-14 |
human |
| Carlos Aparecido da Silva Junior, Danuzia A Marques, Luís Gustavo A Patrone, Vivian Biancardi, Kênia C Bícego, Luciane H Gargaglion. Intra-uterine diazepam exposure decreases the number of catecholaminergic and serotoninergic neurons of neonate rats. Neuroscience letters. 2022-12-15. PMID:36521643. |
thus, we sought to evaluate the effects of intrauterine exposure to dzp on the number of brainstem's catecholaminergic and serotonergic neurons, implicated in respiratory control, in male and female rats on postnatal (p) day 12-13, using immunofluorescence labeling for tyrosine-hydroxylase (th) and serotonin (5-ht). |
2022-12-15 |
2023-08-14 |
rat |
| Lindsay J Agostinelli, Scott C Seaman, Clifford B Saper, Dustin Fykstra, Marco M Hefti, Timothy R Koscik, Brian J Dlouhy, Alexander G Bassu. Human Brainstem and Cerebellum Atlas- Chemoarchitecture and Cytoarchitecture Paired to MRI. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-28. PMID:36442999. |
here, we report a high resolution (200 μm) 7t mri of a cadaveric male human brainstem and cerebellum paired with detailed, coregistered histology (at 2 μm single cell resolution) of the immunohistochemically stained cholinergic, serotonergic, and catecholaminergic (dopaminergic noradrenergic and adrenergic) neurons, in relationship to each other and to the cerebellum. |
2022-11-28 |
2023-08-14 |
human |
| Wei-Li Kuan, Maha Alfaidi, Catherine B Horne, Benjamin Vallin, Sarah Fox, Shaline V Fazal, Caroline H Williams-Gray, Roger A Barke. Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain. Brain pathology (Zurich, Switzerland). 2022-11-02. PMID:36321260. |
our data demonstrated that a non-selective, transvascular delivery of α-synuclein pffs led to a time-dependent loss of specific populations of midbrain (but not olfactory) dopaminergic neurons, medullary (but not pontine) cholinergic neurons, and brainstem serotonergic neurons. |
2022-11-02 |
2023-08-14 |
rat |
| Shu-Hsien Sheu, Srigokul Upadhyayula, Vincent Dupuy, Song Pang, Fei Deng, Jinxia Wan, Deepika Walpita, H Amalia Pasolli, Justin Houser, Silvia Sanchez-Martinez, Sebastian E Brauchi, Sambashiva Banala, Melanie Freeman, C Shan Xu, Tom Kirchhausen, Harald F Hess, Luke Lavis, Yulong Li, Séverine Chaumont-Dubel, David E Clapha. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. vol 185. issue 18. 2022-09-02. PMID:36055200. |
using enhanced focused ion beam-scanning electron microscopy on samples with optimally preserved ultrastructure, we discovered synapses between brainstem serotonergic axons and the primary cilia of hippocampal ca1 pyramidal neurons. |
2022-09-02 |
2023-08-14 |
Not clear |
| Maria J Baltodano-Calle, Melisa Onton-Díaz, Gustavo F Gonzale. Androgens, brain and androgen deprivation therapy in paraphilic disorders: A narrative review. Andrologia. 2022-08-22. PMID:35995581. |
sexual behaviour is regulated by subcortical (hypothalamus, brainstem and spinal cord) and cortical structures of the brain, in addition to brain circuits (dopaminergic, serotonergic). |
2022-08-22 |
2023-08-14 |
human |
| Dominique F Leitner, Evgeny Kanshin, Manor Askenazi, Arline Faustin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Thomas Wisniewski, Orrin Devinsk. Raphe and ventrolateral medulla proteomics in epilepsy and sudden unexpected death in epilepsy. Brain communications. vol 4. issue 4. 2022-08-05. PMID:35928051. |
to understand the potential role of brainstem nuclei in sudden unexpected death in epilepsy, we evaluated molecular signalling pathways using localized proteomics in microdissected midbrain dorsal raphe and medial medullary raphe serotonergic nuclei, as well as the ventrolateral medulla in brain tissue from epilepsy patients who died of sudden unexpected death in epilepsy and other causes in diverse epilepsy syndromes and non-epilepsy control cases ( |
2022-08-05 |
2023-08-14 |
Not clear |
| James M Shine, Claire O'Callaghan, Ishan C Walpola, Gabriel Wainstein, Natasha Taylor, Jaan Aru, Bryce Huebner, Yohan J Joh. Understanding the effects of serotonin in the brain through its role in the gastrointestinal tract. Brain : a journal of neurology. 2022-07-23. PMID:35869620. |
specifically, we outline that central serotonin activity mimics the effects of a digestion/satiety circuit mediated by hypothalamic control over descending serotonergic nuclei in the brainstem. |
2022-07-23 |
2023-08-14 |
Not clear |
| Matthew E Glover, Keaton A Unroe, Mohamad M Moughnyeh, Chelsea McCoy, Ilan A Kerman, Sarah M Clinto. Structural and metabolic activity differences in serotonergic cell groups in a rat model of individual differences of emotionality and stress reactivity. Neuroscience letters. 2022-06-26. PMID:35753615. |
the present study extends these observations with a focus on the organization and the metabolism of brainstem serotonin cell groups that provide serotonergic innervation of the hippocampus and other limbic regions of male hr/lr rats. |
2022-06-26 |
2023-08-14 |
rat |
| Christian P Mülle. Serotonin and Consciousness-A Reappraisal. Behavioural brain research. 2022-06-18. PMID:35716774. |
it is hypothesized that single emotional networks converge on serotonergic and other modulatory transmitter neurons in the brainstem where a bound percept of an affective conscious flow is formed. |
2022-06-18 |
2023-08-14 |
Not clear |