| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Hen-Shoval, T Indig-Naimer, L Moshe, N M Kogan, H Zaidan, I Gaisler-Salomon, E Okun, R Mechoulam, G Shoval, G Zalsman, A Welle. Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression. Journal of psychiatric research. vol 175. 2024-05-05. PMID:38704981. |
the behavioral impact in wky rats coincided with reduced corticosterone serum levels, upregulated mrna expression of cannabinoid receptor 1, fatty acid amide hydrolase, and corticotropin-releasing hormone receptor 1, alongside downregulation of the serotonin transporter in the hippocampus. |
2024-05-05 |
2024-05-08 |
rat |
| Sarah A Elfakharany, Samir S Eskaros, Nesrine M El Azhary, Doaa A Abdelmonsif, Teshreen M Zeitoun, Gamal A G Ammar, Youssef A Hate. Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress. Molecular neurobiology. 2024-05-04. PMID:38703343. |
prefrontal cortical and hippocampal serotonin levels, oxidative stress markers including malondialdehyde (mda), reduced glutathione (gsh) and glutathione peroxidase (gpx), tumor necrosis factor alpha (tnf-α) and caspase-3 were assessed. |
2024-05-04 |
2024-05-07 |
rat |
| Sarah A Elfakharany, Samir S Eskaros, Nesrine M El Azhary, Doaa A Abdelmonsif, Teshreen M Zeitoun, Gamal A G Ammar, Youssef A Hate. Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress. Molecular neurobiology. 2024-05-04. PMID:38703343. |
the present study exhibited the neuroprotective role of senps in rats subjected to crs and proposed their antioxidant, anti-inflammatory and anti-apoptotic effects as the possible mechanism for increased prefrontal cortical and hippocampal serotonin level, ameliorated anxiety-like and depressive-like behaviors and improved prefrontal cortical and hippocampal histological architecture. |
2024-05-04 |
2024-05-07 |
rat |
| Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. |
in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. |
2024-05-04 |
2024-05-07 |
mouse |
| Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkon. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behavioural brain research. 2024-04-30. PMID:38688411. |
in addition, stressed mice showed lower levels of tyrosine, dopamine, dopac, mhpg, kynurenine, kynurenic acid, and 5-hiaa levels but higher serotonin levels in the prefrontal cortex, not in the hippocampus. |
2024-04-30 |
2024-05-03 |
mouse |
| Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. |
analysis of hippocampal transcriptomics suggested that hfpo-ta exposure would impair 5-ht generation and metabolic pathways. |
2024-04-25 |
2024-04-28 |
mouse |
| Xiaoxian Xie, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Shulin Du, Zhengwei Fu, Zezhi L. Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice. Chemosphere. 2024-04-25. PMID:38663680. |
in keeping with this prediction, our findings confirmed that the levels of several neurotransmitters, including tryptophan (trp), 5-ht, 5-htp, and 5-hiaa, were all impaired by hfpo-ta exposure in the serum, colon, and hippocampus, as was the colonic and hippocampal expression of trp and 5-ht metabolism-related genes such as sert, mao-a, and ido. |
2024-04-25 |
2024-04-28 |
mouse |
| Yan-Jia Luo, Hechen Bao, Andrew Crowther, Ya-Dong Li, Ze-Ka Chen, Dalton S Tart, Brent Asrican, Libo Zhang, Juan Son. Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. Cell reports. vol 43. issue 5. 2024-04-24. PMID:38656873. |
sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice. |
2024-04-24 |
2024-04-28 |
mouse |
| Su-Ting Jiang, Shu-Ying Lian, Yao-Huan Sun, Mei-Bo Pan, Bin Wang, Hui Wang, Jun Hua, Yi-Chen Wang, Qiu-Ling Wang, Yin-Feng Don. The oxytocin receptor is essential for the protective effect of pair housing on post-stroke depression in mice. Experimental gerontology. 2024-04-13. PMID:38614224. |
pair housing increased hippocampal serotonin (5-ht), but treatment with l368,889 had no significant impact. |
2024-04-13 |
2024-04-16 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
whereas brain tissue levels of 5-ht and/or its metabolite 5-hiaa tended to decrease during continuous paroxetine, levels increased above controls after discontinuation, notably in hippocampus. |
2024-04-12 |
2024-04-15 |
mouse |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
in microdialysis experiments continuous paroxetine elevated hippocampal extracellular 5-ht and this effect fell to saline control levels on discontinuation. |
2024-04-12 |
2024-04-15 |
mouse |
| Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikuma. Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. Oxford open neuroscience. vol 1. 2024-04-10. PMID:38596711. |
serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal ca2 synapses in male rats. |
2024-04-10 |
2024-04-12 |
rat |
| Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikuma. Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. Oxford open neuroscience. vol 1. 2024-04-10. PMID:38596711. |
considering that there are afferent projections from the serotonergic median raphe to hippocampal ca2, we hypothesized that the neuromodulator serotonin (5-hydroxytryptamine; 5-ht) could modulate ca2 synaptic plasticity. |
2024-04-10 |
2024-04-12 |
rat |
| Amrita Benoy, Lik-Wei Wong, Niha Ather, Sreedharan Sajikuma. Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats. Oxford open neuroscience. vol 1. 2024-04-10. PMID:38596711. |
here, we show that bath-application of serotonin facilitates the persistence of long-term depression (ltd) at the ca3 schaffer collateral inputs to ca2 neurons (sc-ca2) when coupled to a weak low frequency electrical stimulation, in acute rat hippocampal slices. |
2024-04-10 |
2024-04-12 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
the lateral habenula (lhb) projects to the ventral tegmental area (vta) and dorsal raphe nuclei (drn) that deliver dopamine (da) and serotonin (5-ht) to cortical and limbic regions such as the medial prefrontal cortex (mpfc), hippocampus and basolateral amygdala (bla). |
2024-04-08 |
2024-04-11 |
rat |
| Huihui Tan, Chengxue Du, Li Zhang, Yuan Guo, Yaxin Yang, Qingfeng Sun, Qiaojun Zhang, Libo L. Lesions of the lateral habenula excite dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nuclei in hemiparkinsonian rats. Brain research. 2024-04-08. PMID:38588847. |
in addition, lesions of the lhb increased the levels of da and 5-ht in the mpfc, ventral hippocampus and bla compared to sham lesions. |
2024-04-08 |
2024-04-11 |
rat |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
probiotic plus stress consistently reduced the latency to float in the forced swim test, increased da and 5-ht turnovers in the prefrontal cortex, increased hippocampal ne, and reduced hypothalamic da. |
2024-04-03 |
2024-04-06 |
rat |
| Jun Chang, Huimin Yang, Xiaoqian Shan, Lan Zhao, Yujiao Li, Zhao Zhang, Joseph Kofi Abankwah, Mingxing Zhang, Yuhong Bian, Yi Gu. Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-03-30. PMID:38553964. |
the enzyme-linked immunosorbent assay was used to determine the 5-hydroxytryptamine (5-ht), insulin-like growth factor 1 (igf-1) and interleukin-1β (il-1β) in the hipp, serum and cerebrospinal fluid (csf) of rats. |
2024-03-30 |
2024-04-01 |
rat |
| Jackeline Malheiros, Cristiane Amaral, Luiz Severino da Silva, Ruth Guinsburg, Luciene Covola. Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT Behavioural brain research. 2024-03-29. PMID:38552745. |
neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-ht painful invasive procedures are often performed on newborns admitted to intensive care units (icu). |
2024-03-29 |
2024-04-01 |
rat |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
on the other hand, environmental enrichment (ee) is associated with a reduction in anxiety-like and depression-like behavior, as well as an increase in serotonin (5-ht) levels in the prefrontal cortex and hippocampus in rodents. |
2024-03-25 |
2024-03-27 |
human |