| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Jun Hu, Tingting Shen, Jun Xie, Siyang Wang, Yue He, Fu Zh. Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285138. |
moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (hdac1), matrix metalloproteinase-2 (mmp-2) and transforming growth factor β (tgfβ) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group. |
2020-10-01 |
2023-08-13 |
rat |
| Despina Bazou, Mei Rosa Ng, Jonathan W Song, Shan Min Chin, Nir Maimon, Lance L Mun. Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting. Scientific reports. vol 6. 2019-11-20. PMID:27669993. |
furthermore, we show that hdac1 inhibition decreases endothelial morphogenesis and matrix metalloproteinase-14 (mmp14) expression. |
2019-11-20 |
2023-08-13 |
Not clear |
| L J Reynolds, R I Pollack, R J Charnigo, C S Rashid, A J Stromberg, S Shen, J M O'Brien, K J Pearso. Increased birth weight is associated with altered gene expression in neonatal foreskin. Journal of developmental origins of health and disease. vol 8. issue 5. 2018-06-04. PMID:28482944. |
glucose transporter type 4 (glut4), insulin receptor substrate 2 (irs2), leptin receptor (lepr), lipoprotein lipase (lpl), low-density lipoprotein receptor-related protein 1 (lrp1), matrix metalloproteinase 2 (mmp2), plasminogen activator inhibitor-1 (pai-1) and transcription factor 7-like 2 (tcf7l2) were significantly upregulated and histone deacetylase 1 (hdac1) and thioredoxin (txn) downregulated in the larger birth weight neonates v. |
2018-06-04 |
2023-08-13 |
Not clear |
| J Wang, C D Wang, N Zhang, W X Tong, Y F Zhang, S Z Shan, X L Zhang, Q F L. Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1. Cell death & disease. vol 7. 2017-10-31. PMID:27171263. |
the perturbation of hdac1 expression also had a significant effect on matrix mineralization and jag1-mediated notch signaling, suggesting that hdac1 acts as an endogenous attenuator of notch signaling in the mechanotransduction of bmscs. |
2017-10-31 |
2023-08-13 |
mouse |
| Sin Y Choi, Hae J Kee, Thomas Kurz, Finn K Hansen, Yuhee Ryu, Gwi R Kim, Ming Q Lin, Li Jin, Zhe H Piao, Myung H Jeon. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. Journal of cellular and molecular medicine. vol 20. issue 12. 2017-07-11. PMID:27420561. |
here, we investigated emt markers and extracellular matrix (ecm) proteins in a human proximal tubular cell line (hk-2) by using hdac inhibitors or by knockdown of class i hdacs (hdac1, 2, 3 and 8). |
2017-07-11 |
2023-08-13 |
human |
| Sunil K Malonia, Bhawna Yadav, Surajit Sinha, Gwendel Lazennec, Samit Chattopadhya. Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer. The international journal of biochemistry & cell biology. vol 55. 2015-07-24. PMID:25239884. |
using chromatin immunoprecipitation and reporter assays, we demonstrate that smar1 binds to il-8 promoter mar (matrix attachment region) and recruits hdac1 dependent co-repressor complex. |
2015-07-24 |
2023-08-13 |
Not clear |
| Pankaj Chaturvedi, Anuradha Kalani, Srikanth Givvimani, Pradip Kumar Kamat, Anastasia Familtseva, Suresh C Tyag. Differential regulation of DNA methylation versus histone acetylation in cardiomyocytes during HHcy in vitro and in vivo: an epigenetic mechanism. Physiological genomics. vol 46. issue 7. 2014-12-28. PMID:24495916. |
in hhcy, the expression of nmdar1, dnmt1, and matrix metalloproteinase 9 increased with increase in h3k9 acetylation, while hdac1, mir-133a, and mir-499 decreased in cardiomyocytes. |
2014-12-28 |
2023-08-12 |
mouse |
| L Rosanò, R Cianfrocca, P Tocci, F Spinella, V Di Castro, F Spadaro, E Salvati, A M Biroccio, P G Natali, A Bagnat. β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling. Oncogene. vol 32. issue 42. 2013-12-23. PMID:23208497. |
β-arr1-β-catenin interaction controls β-catenin target gene expressions, such as et-1, axin 2, matrix metalloproteinase 2, and cyclin d1, by promoting histone deacetylase 1 (hdac1) dissociation and the recruitment of p300 acetyltransferase on these promoter genes, resulting in enhanced h3 and h4 histone acetylation, and gene transcription, required for cell migration, invasion and epithelial-to-mesenchymal transition. |
2013-12-23 |
2023-08-12 |
human |
| Kiran K Nakka, Samit Chattopadhya. Modulation of chromatin by MARs and MAR binding oncogenic transcription factor SMAR1. Molecular and cellular biochemistry. vol 336. issue 1-2. 2010-06-01. PMID:19802523. |
smar1 is a matrix attachment region binding protein that interacts with chromatin modulators like hdac1, sin3a and causes chromatin condensation. |
2010-06-01 |
2023-08-12 |
Not clear |
| Sohee Hong, Assia Derfoul, Lucilia Pereira-Mouries, David J Hal. A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 10. 2009-11-05. PMID:19561124. |
when expressed in these cells, hdac1 and hdac2 repressed aggrecan and collagen 2(alpha1) expression but differed in their repression of collagen 9(alpha1), collagen 11(alpha1), dermatopontin, and cartilage oligomeric matrix protein (comp). |
2009-11-05 |
2023-08-12 |
human |
| Katherine L Dunn, Helen Zhao, James R Davi. The insulator binding protein CTCF associates with the nuclear matrix. Experimental cell research. vol 288. issue 1. 2003-09-24. PMID:12878173. |
we also show that the chromatin-modifying enzymes hdac1 and hdac2, which are intrinsic nuclear matrix components and thought to function as corepressors of ctcf, are incapable of associating with ctcf. |
2003-09-24 |
2023-08-12 |
Not clear |
| J M Sun, H Y Chen, M Moniwa, S Samuel, J R Davi. Purification and characterization of chicken erythrocyte histone deacetylase 1. Biochemistry. vol 38. issue 18. 1999-06-01. PMID:10231548. |
further, we show that hdac1 is associated with the erythroid nuclear matrix and that the enzyme is bound to nuclear dna in situ. |
1999-06-01 |
2023-08-12 |
chicken |
| C A Hassig, J K Tong, T C Fleischer, T Owa, P G Grable, D E Ayer, S L Schreibe. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520398. |
antibodies directed against endogenous hdac1, hdac2, or hdac3 immunoprecipitate histone deacetylase activity that is inhibited in vitro by the small molecule trapoxin (tpx), and all three hdacs are retained by a tpx-affinity matrix. |
1998-05-01 |
2023-08-12 |
Not clear |