All Relations between dopamine and thy-1
| Publication | Sentence | Publish Date | Extraction Date | Species |
|---|---|---|---|---|
| Franziska Richter, Milos Stanojlovic, Christopher Käufer, Birthe Gericke, Malte Fej. A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn ("line 61") Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-01-30. PMID:36715870. | mice over-expressing full-length, human, wild-type alpha-synuclein under the thy-1 promoter (thy1-asyn line 61) reproduce key features of sporadic pd, such as progressive loss of striatal dopamine, alpha-synuclein pathology, deficits in motor and non-motor functions, and elevation of inflammatory markers. | 2023-01-30 | 2023-08-14 | mouse |
| Hannah Bender, Simone A Fietz, Franziska Richter, Milos Stanojlovi. Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus. Frontiers in cell and developmental biology. vol 9. 2021-07-27. PMID:34307368. | mice overexpressing wild-type alpha-synuclein under the thy-1 promoter (thy1-asyn, line 61) uniquely replicate early cognitive deficits together with multiple other characteristic motor and non-motor symptoms, alpha-synuclein pathology and dopamine loss. | 2021-07-27 | 2023-08-13 | mouse |
| N Carkaci-Salli, S Battula, X Wang, J R Connor, K E Vran. Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice. Journal of neuroscience research. vol 90. issue 8. 2012-10-05. PMID:22430860. | in addition, thy-1 knockouts (ko) are a potential mouse model of restless legs syndrome (rls) based on clinical observations and the role of dopamine in the disease. | 2012-10-05 | 2023-08-12 | mouse |
| S M Fleming, J Salcedo, C B Hutson, E Rockenstein, E Masliah, M S Levine, M-F Chessele. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein. Neuroscience. vol 142. issue 4. 2007-02-27. PMID:16934409. | we have examined the behavioral effects of direct and indirect dopaminergic agonists in transgenic mice expressing human alpha-synuclein under the thy-1 promoter (thy1-asyn, alpha-synuclein overexpressor), which exhibit progressive impairments in behavioral tests sensitive to nigrostriatal dopamine dysfunction. | 2007-02-27 | 2023-08-12 | mouse |