| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
preliminary evidence from the dorsal striatum of cocaine-experienced rats suggests that this region exhibits similar alterations to glutamate clearance and release, but it is not known whether these glutamate dynamics are associated with goal-directed or habitual control over cocaine-seeking behavior. |
2023-05-30 |
2023-08-14 |
rat |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. |
2023-05-30 |
2023-08-14 |
rat |
| Jiang-Fan Chen, Doo-Sup Choi, Rodrigo A Cunh. Striatopallidal adenosine A Neuropharmacology. 2023-01-12. PMID:36634866. |
the current investigation of goal-directed behaviors has concentrated on dopamine and glutamate signaling in the corticostriatal pathway. |
2023-01-12 |
2023-08-14 |
Not clear |
| Megan L Shipman, Laura H Corbi. Diet-induced deficits in goal-directed control are rescued by agonism of group II metabotropic glutamate receptors in the dorsomedial striatum. Translational psychiatry. vol 12. issue 1. 2022-01-29. PMID:35091538. |
we found that an obesogenic diet reduced goal-directed control and that systemic injection of ly379268, a group ii metabotropic glutamate receptor (mglur2/3) agonist, returned goal-directed responding in these rats. |
2022-01-29 |
2023-08-13 |
rat |
| Megan L Shipman, Laura H Corbi. Diet-induced deficits in goal-directed control are rescued by agonism of group II metabotropic glutamate receptors in the dorsomedial striatum. Translational psychiatry. vol 12. issue 1. 2022-01-29. PMID:35091538. |
diet-induced deficits in goal-directed control are rescued by agonism of group ii metabotropic glutamate receptors in the dorsomedial striatum. |
2022-01-29 |
2023-08-13 |
rat |
| Kari A Johnson, Lucas Voyvodic, Gabriel C Loewinger, Yolanda Mateo, David M Lovinge. Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:31995814. |
we evaluated the reinforcing properties of optogenetic stimulation of thalamostriatal terminals, which are associated with vesicular glutamate transporter 2 (vglut2) expression, in the dorsomedial striatum (dms), a region implicated in goal-directed behaviors. |
2021-06-23 |
2023-08-13 |
mouse |
| Mathieu Favier, Helena Janickova, Damian Justo, Ornela Kljakic, Léonie Runtz, Joman Y Natsheh, Tharick A Pascoal, Jurgen Germann, Daniel Gallino, Jun-Ii Kang, Xiang Qi Meng, Christina Antinora, Sanda Raulic, Jacob Pr Jacobsen, Luc Moquin, Erika Vigneault, Alain Gratton, Marc G Caron, Philibert Duriez, Mark P Brandon, Pedro Rosa Neto, M Mallar Chakravarty, Mohammad M Herzallah, Philip Gorwood, Marco Am Prado, Vania F Prado, Salah El Mestikaw. Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating. The Journal of clinical investigation. vol 130. issue 12. 2021-02-16. PMID:33164988. |
silencing glutamate favored goal-directed behaviors and had no impact on eating behavior. |
2021-02-16 |
2023-08-13 |
mouse |
| Nigel S Bamford, Wengang Wan. Corticostriatal plasticity in the nucleus accumbens core. Journal of neuroscience research. vol 97. issue 12. 2020-08-21. PMID:31298422. |
small fluctuations in striatal glutamate and dopamine are required to establish goal-directed behaviors and motor learning, while large changes appear to underlie many neuropsychological disorders, including drug dependence and parkinson's disease. |
2020-08-21 |
2023-08-13 |
mouse |
| Brionna D Davis-Reyes, Veronica M Campbell, Michelle A Land, Holly L Chapman, Susan J Stafford, Noelle C Anastasi. Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats. Biochemical pharmacology. vol 168. 2020-07-13. PMID:31295463. |
glutamate neurotransmission through the n-methyl-d-aspartate receptors (nmdars) in the medial prefrontal cortex (mpfc), an important brain region in decision-making and goal-directed behaviors, plays a key role in motor impulsivity. |
2020-07-13 |
2023-08-13 |
rat |
| Teri M Furlong, Laura H Corbit, Robert A Brown, Bernard W Ballein. Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum. Addiction biology. vol 23. issue 3. 2019-08-28. PMID:28707389. |
in the dorsomedial striatum, a structure critical for goal-directed action, meth exposure was associated with a reduction in glutamate receptor and glutamate vesicular proteins, whereas in the dorsolateral striatum, a region that has previously been implicated in habit learning, there was an increase in these proteins. |
2019-08-28 |
2023-08-13 |
Not clear |
| Laura H Corbit, Billy C Chieng, Bernard W Ballein. Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24531561. |
exposure to drugs of abuse can result in a loss of control over both drug- and nondrug-related actions by accelerating the transition from goal-directed to habitual control, an effect argued to reflect changes in glutamate homeostasis. |
2015-02-12 |
2023-08-12 |
human |
| Joel E Shillinglaw, Ian K Everitt, Donita L Robinso. Assessing behavioral control across reinforcer solutions on a fixed-ratio schedule of reinforcement in rats. Alcohol (Fayetteville, N.Y.). vol 48. issue 4. 2014-12-31. PMID:24680666. |
therefore, we trained rats to self-administer 1.5% sucrose, 10% sucrose, 10% ethanol, or 10 mm monosodium glutamate (msg) on a fixed-ratio (fr5) schedule that has been shown to promote long-term, goal-directed responding. |
2014-12-31 |
2023-08-12 |
rat |
| Carlos A Jiménez-Rivera, Johnny Figueroa, Rafael Vázquez-Torres, María E Vélez-Hernandez, David Schwarz, María C Velásquez-Martinez, Francisco Arencibia-Albit. Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA. The European journal of neuroscience. vol 35. issue 9. 2012-09-10. PMID:22564071. |
glutamate transmission within the vta controls important aspects of goal-directed behavior and motivation. |
2012-09-10 |
2023-08-12 |
rat |
| Marc A Beckerman, Michael J Glas. Ultrastructural relationship between the AMPA-GluR2 receptor subunit and the mu-opioid receptor in the mouse central nucleus of the amygdala. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20970421. |
activation of glur2-expressing non-calcium-permeable ampa-type glutamate receptors in the central nucleus of the amygdala (cea) may play an important role in integrating emotion and memory with goal-directed behaviors involved in opioid addiction. |
2011-02-04 |
2023-08-12 |
mouse |
| N Chuhma, W Y Choi, S Mingote, S Raypor. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19729052. |
dopamine neuron glutamate cotransmission may play an important role in encoding the incentive salience value of conditioned stimuli that activate goal-directed behaviors, and may be an important subtract for enduring drug-seeking behaviors. |
2010-02-08 |
2023-08-12 |
mouse |
| John G Kerns, Keith H Nuechterlein, Todd S Braver, Deanna M Barc. Executive functioning component mechanisms and schizophrenia. Biological psychiatry. vol 64. issue 1. 2008-08-15. PMID:18549874. |
executive functioning refers to a set of processes involved in complex, goal-directed thought and behavior involving multiple brain regions (e.g., prefrontal cortex, parietal cortex, basal ganglia) and multiple neurotransmitters (e.g., dopamine, glutamate, gamma-aminobutyric acid). |
2008-08-15 |
2023-08-12 |
Not clear |
| Justine Masson, Michèle Darmon, Agnès Conjard, Nao Chuhma, Nicole Ropert, Muriel Thoby-Brisson, Arthur S Foutz, Sandrine Parrot, Gretchen M Miller, Renée Jorisch, Jonathan Polan, Michel Hamon, René Hen, Stephen Raypor. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641247. |
our results show that although alternate pathways to gls1 glutamate synthesis support baseline glutamatergic transmission, the gls1 pathway is essential for maintaining the function of active synapses, and thus the mutation is associated with impaired respiratory function, abnormal goal-directed behavior, and neonatal demise. |
2006-05-23 |
2023-08-12 |
mouse |
| Irene A Yun, Saleem M Nicola, Howard L Field. Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior. The European journal of neuroscience. vol 20. issue 1. 2004-09-07. PMID:15245497. |
contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue-evoked goal-directed behavior. |
2004-09-07 |
2023-08-12 |
rat |