| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasmus Rydbirk, Betina Elfving, Jonas Folke, Bente Pakkenberg, Kristian Winge, Tomasz Brudek, Susana Azna. Increased prefrontal cortex interleukin-2 protein levels and shift in the peripheral T cell population in progressive supranuclear palsy patients. Scientific reports. vol 9. issue 1. 2020-10-19. PMID:31123295. |
il-2 and gsk3b proteins are t and natural killer (nk) cell regulators and have previously been associated with other neurodegenerative diseases such as alzheimer's disease, parkinson's disease and multiple system atrophy. |
2020-10-19 |
2023-08-13 |
Not clear |
| Kotaro Ogaki, Michael G Heckman, Shunsuke Koga, Yuka A Martens, Catherine Labbé, Oswaldo Lorenzo-Betancor, Ronald L Walton, Alexandra I Soto, Emily R Vargas, Shinsuke Fujioka, Ryan J Uitti, Jay A van Gerpen, William P Cheshire, Steven G Younkin, Zbigniew K Wszolek, Phillip A Low, Wolfgang Singer, Guojun Bu, Dennis W Dickson, Owen A Ros. Association study between multiple system atrophy and TREM2 p.R47H. Neurology. Genetics. vol 4. issue 4. 2020-09-30. PMID:30109269. |
the triggering receptor expressed on myeloid cells 2 (trem2) p.r47h substitution (rs75932628) is a risk factor for alzheimer disease (ad) but has not been well studied in relation to the risk of multiple system atrophy (msa); the aim of this study was to evaluate the association between the trem2 p.r47h variant and the risk of msa. |
2020-09-30 |
2023-08-13 |
Not clear |
| Michiyo Iba, Changyoun Kim, Jazmin Florio, Michael Mante, Anthony Adame, Edward Rockenstein, Somin Kwon, Robert Rissman, Eliezer Maslia. Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32296304. |
progressive accumulation of the pre-synaptic protein α-synuclein (α-syn) has been strongly associated with the pathogenesis of neurodegenerative disorders of the aging population such as alzheimer's disease (ad), parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple system atrophy. |
2020-09-28 |
2023-08-13 |
mouse |
| Ana Gámez-Valero, Katrin Beye. Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies. Genes. vol 9. issue 2. 2019-11-20. PMID:29370097. |
the synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including parkinson's disease (pd) as most important movement disorder, dementia with lewy bodies (dlb) as the second most frequent cause of dementia after alzheimer's disease and multiple system atrophy. |
2019-11-20 |
2023-08-13 |
Not clear |
| Nathan P Staff, David T Jones, Wolfgang Singe. Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases. Mayo Clinic proceedings. vol 94. issue 5. 2019-10-17. PMID:31054608. |
we then provide a summary of preclinical and early clinical work on msc therapies in amyotrophic lateral sclerosis, multiple system atrophy, parkinson disease, and alzheimer disease. |
2019-10-17 |
2023-08-13 |
Not clear |
| Yuta Takaichi, Yasuhisa Ano, James K Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. Deposition of Phosphorylated α-Synuclein in the rTg4510 Mouse Model of Tauopathy. Journal of neuropathology and experimental neurology. vol 77. issue 10. 2019-10-03. PMID:30107539. |
specifically, hyperphosphorylated tau (hp-tau) accumulates in alzheimer disease, frontotemporal dementia with parkinsonism linked to chromosome 17, and progressive supranuclear palsy; furthermore, phosphorylated α-synuclein (p-αsyn) accumulates in parkinson disease, dementia with lewy bodies, and multiple system atrophy. |
2019-10-03 |
2023-08-13 |
mouse |
| Alexandra I Mot, Constanze Depp, Klaus-Armin Nav. An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases. Dialogues in clinical neuroscience. vol 20. issue 4. 2019-05-07. PMID:30936768. |
these findings represent a paradigm shift for the physiological function of axon-associated glia, and open the intriguing possibility that oligodendrocytes are important contributors to neurodegenerative diseases in which myelinated axons are lost, such as in alzheimer disease, amyotrophic lateral sclerosis, and multiple system atrophy. |
2019-05-07 |
2023-08-13 |
Not clear |
| Sara Gerhardt, M Hasan Mohajer. Changes of Colonic Bacterial Composition in Parkinson's Disease and Other Neurodegenerative Diseases. Nutrients. vol 10. issue 6. 2018-10-15. PMID:29857583. |
in this review, we performed a systematic evaluation of the published literature comparing changes in colonic microbiome in pd to the ones observed in other nds including alzheimer's disease (ad), multiple system atrophy (msa), multiple sclerosis (ms), neuromyelitis optica (nmo) and amyotrophic lateral sclerosis (als). |
2018-10-15 |
2023-08-13 |
human |
| Kurt Giles, Amanda L Woerman, David B Berry, Stanley B Prusine. Bioassays and Inactivation of Prions. Cold Spring Harbor perspectives in biology. vol 9. issue 8. 2018-04-23. PMID:28246183. |
a wealth of recent data argues that both β-amyloid (aβ) and tau proteins form prions that cause alzheimer's disease, and α-synuclein forms prions that cause multiple system atrophy and parkinson's disease. |
2018-04-23 |
2023-08-13 |
Not clear |
| Amy R Dunn, Kristen A Stout, Minagi Ozawa, Kelly M Lohr, Carlie A Hoffman, Alison I Bernstein, Yingjie Li, Minzheng Wang, Carmelo Sgobio, Namratha Sastry, Huaibin Cai, W Michael Caudle, Gary W Mille. Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 11. 2018-04-23. PMID:28246328. |
furthermore, sv2c expression is dramatically altered in postmortem brain tissue from pd cases but not in alzheimer disease, progressive supranuclear palsy, or multiple system atrophy. |
2018-04-23 |
2023-08-13 |
mouse |
| Edward Pokrishevsky, Ran Ha Hong, Ian R Mackenzie, Neil R Cashma. Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells. PloS one. vol 12. issue 9. 2017-10-23. PMID:28877271. |
we observed that human spinal cord homogenates prepared from sod1 familial als (fals) can induce significantly more intracellular reporter protein aggregation than spinal cord homogenates from sporadic als, alzheimer's disease, multiple system atrophy or healthy control individuals. |
2017-10-23 |
2023-08-13 |
human |
| Helena M Gellersen, Christine C Guo, Claire O'Callaghan, Rachel H Tan, Saber Sami, Michael Hornberge. Cerebellar atrophy in neurodegeneration-a meta-analysis. Journal of neurology, neurosurgery, and psychiatry. vol 88. issue 9. 2017-09-11. PMID:28501823. |
the current meta-analysis aims to assess patterns of cerebellar grey matter atrophy in seven neurodegenerative conditions (alzheimer's disease (ad), parkinson's disease (pd) and huntington's disease (hd), frontotemporal dementia (ftd), amyotrophic lateral sclerosis (als), multiple system atrophy (msa), progressive supranuclear palsy (msp)). |
2017-09-11 |
2023-08-13 |
Not clear |
| b' Hana P\\xc5\\x99ikrylov\\xc3\\xa1 Vranov\\xc3\\xa1, Eva H\\xc3\\xa9nykov\\xc3\\xa1, Jan Mare\\xc5\\xa1, Michaela Kaiserov\\xc3\\xa1, Kate\\xc5\\x99ina Men\\xc5\\xa1\\xc3\\xadkov\\xc3\\xa1, Miroslav Va\\xc5\\xa1t\\xc3\\xadk, Petr Hlu\\xc5\\xa1t\\xc3\\xadk, Jana Zapletalov\\xc3\\xa1, Miroslav Strnad, David Stejskal, Petr Ka\\xc5\\x88ovsk\\xc3\\xb. Clusterin CSF levels in differential diagnosis of neurodegenerative disorders. Journal of the neurological sciences. vol 361. 2016-10-20. PMID:26810527.' |
in the brain, post-mortem analysis has found increased clusterin associated with the pathology of many other neurodegenerative diseases (nd) such as parkinson's disease (pd), dementia with lewy bodies (dlb), alzheimer's disease (ad) and multiple system atrophy (msa). |
2016-10-20 |
2023-08-13 |
Not clear |
| Richard A Armstrong, Nigel J Cairn. Comparative quantitative study of 'signature' pathological lesions in the hippocampus and adjacent gyri of 12 neurodegenerative disorders. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 10. 2016-07-06. PMID:25929331. |
principal components analysis of the data suggested that the disorders could be divided into three groups: (1) alzheimer's disease (ad), down's syndrome (ds), sporadic creutzfeldt-jakob disease, and variant creutzfeldt-jakob disease in which either β-amyloid (aβ) or prion protein deposits were distributed in all sectors of the hc and adjacent gyri, with high densities being recorded in the parahippocampal gyrus and subiculum; (2) pick's disease, sporadic frontotemporal lobar degeneration with tdp-43 immunoreactive inclusions, and neuronal intermediate filament inclusion disease in which relatively high densities of neuronal cytoplasmic inclusions were present in the dentate gyrus (dg) granule cells; and (3) parkinson's disease dementia, dementia with lewy bodies, progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy in which densities of signature lesions were relatively low. |
2016-07-06 |
2023-08-13 |
Not clear |
| Zheng-Yu Wang, Zhen-Min Han, Qi-Fei Liu, Wei Tang, Kui Ye, Yu-You Ya. Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders. International psychogeriatrics. vol 27. issue 9. 2016-05-04. PMID:25851548. |
this is especially true in differentiating alzheimer's disease (ad), dementia with lewy bodies (dlb), parkinson disease (pd), and multiple system atrophy (msa). |
2016-05-04 |
2023-08-13 |
Not clear |
| Mathilde Renaud, Julien Perriard, Sarah Coudray, Mathieu Sévin-Allouet, Christophe Marcel, Wassilios G Meissner, Jean-Baptiste Chanson, Nicolas Collongues, Nathalie Philippi, Odile Gebus, Véronique Quenardelle, Anna Castrioto, Paul Krack, Karine N'Guyen, François Lefebvre, Andoni Echaniz-Laguna, Jean-Philippe Azulay, Nicolas Meyer, Pierre Labauge, Christine Tranchant, Mathieu Anhei. Relevance of corpus callosum splenium versus middle cerebellar peduncle hyperintensity for FXTAS diagnosis in clinical practice. Journal of neurology. vol 262. issue 2. 2015-12-02. PMID:25451852. |
clinical and radiological study of 22 fmr1 premutation carriers with neurological signs that may be encountered in fxtas compared to series of patients with essential tremor, multiple system atrophy of cerebellar type, parkinson's disease, alzheimer's disease and stroke. |
2015-12-02 |
2023-08-13 |
Not clear |
| Lauren D Stutzbach, Sharon X Xie, Adam C Naj, Roger Albin, Sid Gilman, Virginia M Y Lee, John Q Trojanowski, Bernie Devlin, Gerard D Schellenber. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252572. |
recently, several groups noted upr activation in alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis, multiple system atrophy, and in the hippocampus and substantia nigra of psp subjects. |
2015-03-31 |
2023-08-12 |
human |
| Steven E Arnold, Jon B Toledo, Dina H Appleby, Sharon X Xie, Li-San Wang, Young Baek, David A Wolk, Edward B Lee, Bruce L Miller, Virginia M-Y Lee, John Q Trojanowsk. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of comparative neurology. vol 521. issue 18. 2014-06-11. PMID:23881776. |
these include: 1) amyloid-β and tau lesions in alzheimer's disease; 2) tau lesions in three other tauopathies including pick's disease, progressive supranuclear palsy and corticobasal degeneration; 3) α-synuclein inclusion ratings in four synucleinopathies including parkinson's disease, parkinson's disease with dementia, dementia with lewy bodies, and multiple system atrophy; and 4) tdp-43 lesions in two tdp-43 proteinopathies, including frontotemporal lobar degeneration associated with tdp-43 and amyotrophic lateral sclerosis. |
2014-06-11 |
2023-08-12 |
Not clear |
| Takashi Kurashige, Tetsuya Takahashi, Yuu Yamazaki, Masanori Hiji, Yuishin Izumi, Takemori Yamawaki, Masayasu Matsumot. Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 33. issue 3. 2014-01-10. PMID:22989140. |
we examined the brainstems of 17 patients with parkinson's disease (pd), incidental lewy body disease (ilbd), multiple system atrophy (msa), and alzheimer's disease (ad) immunohistochemically using antibodies against phosphorylated αs (pαs), phosphorylated tau and chmp2b. |
2014-01-10 |
2023-08-12 |
Not clear |
| Richard A Armstrong, Nigel J Cairn. Different molecular pathologies result in similar spatial patterns of cellular inclusions in neurodegenerative disease: a comparative study of eight disorders. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 12. 2013-07-22. PMID:22678700. |
hence, the spatial patterns of nci were compared in four tauopathies, viz., alzheimer's disease, pick's disease, corticobasal degeneration, and progressive supranuclear palsy, two synucleinopathies, viz., dementia with lewy bodies and multiple system atrophy, the 'fused in sarcoma' (fus)-immunoreactive inclusions in neuronal intermediate filament inclusion disease, and the transactive response dna-binding protein (tdp-43)-immunoreactive inclusions in frontotemporal lobar degeneration, a tdp-43 proteinopathy (ftld-tdp). |
2013-07-22 |
2023-08-12 |
Not clear |