| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Poduri, M Gearing, G W Rebeck, S S Mirra, J Tigges, B T Hyma. Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. The American journal of pathology. vol 144. issue 6. 1994-07-05. PMID:8203459. |
recent studies of late onset familial and sporadic alzheimer's disease (ad) show a genetic disequilibrium between inheritance of the epsilon 4 allele of the apolipoprotein e (apoe) gene and development of ad. |
1994-07-05 |
2023-08-12 |
mouse |
| C Talbot, C Lendon, N Craddock, S Shears, J C Morris, A Goat. Protection against Alzheimer's disease with apoE epsilon 2. Lancet (London, England). vol 343. issue 8910. 1994-06-28. PMID:7910910. |
protection against alzheimer's disease with apoe epsilon 2. |
1994-06-28 |
2023-08-12 |
Not clear |
| B P Nathan, S Bellosta, D A Sanan, K H Weisgraber, R W Mahley, R E Pita. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science (New York, N.Y.). vol 264. issue 5160. 1994-06-01. PMID:8171342. |
apolipoprotein e4 (apoe4), one of the three common isoforms of apoe, has been implicated in alzheimer's disease. |
1994-06-01 |
2023-08-12 |
Not clear |
| C E Yu, H Payami, J M Olson, M Boehnke, E M Wijsman, H T Orr, W A Kukull, K A Goddard, E Nemens, J A Whit. The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. American journal of human genetics. vol 54. issue 4. 1994-04-13. PMID:8128960. |
evidence of linkage of apoe and apocii to fad was examined by maximum-likelihood methods, using three models and assuming autosomal dominant inheritance: (1) age-dependent penetrance, (2) extremely low (1%) penetrance, and (3) age-dependent penetrance corrected for sporadic alzheimer disease (ad). |
1994-04-13 |
2023-08-12 |
human |
| M E Gåfvels, M Caird, D Britt, C L Jackson, D Patterson, J F Straus. Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23. Somatic cell and molecular genetics. vol 19. issue 6. 1994-04-11. PMID:8128315. |
expression in brain may be related to high levels of apoe expression in that organ, an observation of potential relevance to the recently hypothesized role for apoe in late onset alzheimer disease. |
1994-04-11 |
2023-08-12 |
mouse |
| J S Whitson, M P Mims, W J Strittmatter, T Yamaki, J D Morrisett, S H Appe. Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E. Biochemical and biophysical research communications. vol 199. issue 1. 1994-04-01. PMID:8123007. |
thus, interaction between these proteins does not directly increase a beta neurotoxicity, and the role of apoe in alzheimer's disease remains to be elucidated. |
1994-04-01 |
2023-08-12 |
Not clear |
| M L Peacock, J K Fin. ApoE epsilon 4 allelic association with Alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. Neurology. vol 44. issue 2. 1994-03-17. PMID:8309587. |
apoe epsilon 4 allelic association with alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. |
1994-03-17 |
2023-08-12 |
human |
| M L Peacock, J K Fin. ApoE epsilon 4 allelic association with Alzheimer's disease: independent confirmation using denaturing gradient gel electrophoresis. Neurology. vol 44. issue 2. 1994-03-17. PMID:8309587. |
there is intriguing evidence associating apolipoprotein e (apoe) with alzheimer's disease (ad). |
1994-03-17 |
2023-08-12 |
human |
| J Hard. ApoE, amyloid, and Alzheimer's disease. Science (New York, N.Y.). vol 263. issue 5146. 1994-02-18. PMID:8290946. |
apoe, amyloid, and alzheimer's disease. |
1994-02-18 |
2023-08-12 |
Not clear |
| G W Rebeck, J S Reiter, D K Strickland, B T Hyma. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron. vol 11. issue 4. 1993-11-22. PMID:8398148. |
an increased prevalence of apolipoprotein e (apoe) epsilon 4 allele exists in late onset familial alzheimer's disease. |
1993-11-22 |
2023-08-12 |
Not clear |
| J Poirier, J Davignon, D Bouthillier, S Kogan, P Bertrand, S Gauthie. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet (London, England). vol 342. issue 8873. 1993-10-08. PMID:8103819. |
apolipoprotein e (apoe) is associated with alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques. |
1993-10-08 |
2023-08-12 |
Not clear |
| J Poirier, J Davignon, D Bouthillier, S Kogan, P Bertrand, S Gauthie. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet (London, England). vol 342. issue 8873. 1993-10-08. PMID:8103819. |
the gene for apoe is on chromosome 19, within the genomic region previously associated with late-onset familial alzheimer's disease (ad). |
1993-10-08 |
2023-08-12 |
Not clear |
| W J Strittmatter, K H Weisgraber, D Y Huang, L M Dong, G S Salvesen, M Pericak-Vance, D Schmechel, A M Saunders, D Goldgaber, A D Rose. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 17. 1993-10-05. PMID:8367470. |
apolipoprotein e (apoe), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of alzheimer disease. |
1993-10-05 |
2023-08-12 |
human |
| W J Strittmatter, K H Weisgraber, D Y Huang, L M Dong, G S Salvesen, M Pericak-Vance, D Schmechel, A M Saunders, D Goldgaber, A D Rose. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 17. 1993-10-05. PMID:8367470. |
late-onset familial and sporadic alzheimer disease patients have an increased frequency of one of the three common apoe alleles, epsilon 4, suggesting apoe4 is associated with increased susceptibility to disease. |
1993-10-05 |
2023-08-12 |
human |
| W J Strittmatter, K H Weisgraber, D Y Huang, L M Dong, G S Salvesen, M Pericak-Vance, D Schmechel, A M Saunders, D Goldgaber, A D Rose. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 17. 1993-10-05. PMID:8367470. |
binding of beta/a4 peptide by oxidized apoe may determine the sequestration or targeting of either apoe or beta/a4 peptide, and isoform-specific differences in apoe binding or oxidation may be involved in the pathogenesis of the intra- and extracellular lesions of alzheimer disease. |
1993-10-05 |
2023-08-12 |
human |
| A M Saunders, W J Strittmatter, D Schmechel, P H George-Hyslop, M A Pericak-Vance, S H Joo, B L Rosi, J F Gusella, D R Crapper-MacLachlan, M J Albert. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. vol 43. issue 8. 1993-09-15. PMID:8350998. |
apolipoprotein e, type epsilon 4 allele (apoe epsilon 4), is associated with late-onset familial alzheimer's disease (ad). |
1993-09-15 |
2023-08-12 |
Not clear |
| J Bignal. APOE gene dose in Alzheimer's disease. Lancet (London, England). vol 342. issue 8868. 1993-09-02. PMID:8101911. |
apoe gene dose in alzheimer's disease. |
1993-09-02 |
2023-08-12 |
Not clear |