| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca Passamonti, Patricia Vázquez Rodríguez, Young T Hong, Kieren S J Allinson, David Williamson, Robin J Borchert, Saber Sami, Thomas E Cope, W Richard Bevan-Jones, P Simon Jones, Robert Arnold, Ajenthan Surendranathan, Elijah Mak, Li Su, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. 18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28122879. |
conversely, in patients with progressive supranuclear palsy, relative to patients with alzheimer's disease, 18f-av-1451 binding was elevated in the midbrain (t = 2.1, p < 0.04); while patients with progressive supranuclear palsy showed, relative to controls, increased 18f-av-1451 uptake in the putamen, pallidum, thalamus, midbrain, and in the dentate nucleus of the cerebellum (t's > 2.7, p's < 0.02). |
2017-05-29 |
2023-08-13 |
human |
| Junya Toba, Miyu Nikkuni, Masato Ishizeki, Aya Yoshii, Naoto Watamura, Takafumi Inoue, Toshio Ohshim. PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice. Biochemical and biophysical research communications. vol 473. issue 4. 2017-05-10. PMID:27059136. |
pparγ agonist pioglitazone improves cerebellar dysfunction at pre-aβ deposition stage in appswe/ps1de9 alzheimer's disease model mice. |
2017-05-10 |
2023-08-13 |
mouse |
| Christine C Guo, Rachel Tan, John R Hodges, Xintao Hu, Saber Sami, Michael Hornberge. Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26912642. |
network-selective vulnerability of the human cerebellum to alzheimer's disease and frontotemporal dementia. |
2017-05-08 |
2023-08-13 |
human |
| Christine C Guo, Rachel Tan, John R Hodges, Xintao Hu, Saber Sami, Michael Hornberge. Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia. Brain : a journal of neurology. vol 139. issue Pt 5. 2017-05-08. PMID:26912642. |
our results showed that alzheimer's disease and frontotemporal dementia are associated with distinct and circumscribed atrophy in the cerebellum. |
2017-05-08 |
2023-08-13 |
human |
| Roberto E Sica, Roberto Caccuri, Cecilia Quarracino, Francisco Capan. Are astrocytes executive cells within the central nervous system? Arquivos de neuro-psiquiatria. vol 74. issue 8. 2017-05-02. PMID:27556379. |
on the other hand, experimental findings and human observations signal that some of the primary degenerative diseases of the cns, like frontotemporal dementia, parkinson's disease, alzheimer's dementia, huntington's dementia, primary cerebellar ataxias and amyotrophic lateral sclerosis, all of which affect the human species exclusively, may be due to astroglial dysfunction. |
2017-05-02 |
2023-08-13 |
human |
| Guiyou Liu, Xinjie Bao, Yongshuai Jiang, Mingzhi Liao, Qinghua Jiang, Rennan Feng, Liangcai Zhang, Guoda Ma, Zugen Chen, Guangyu Wang, Renzhi Wang, Bin Zhao, Keshen L. Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network. Molecular neurobiology. vol 52. issue 3. 2016-08-30. PMID:25370933. |
here, we conducted a systems analysis using (1) ad and pd variants (p < 5.00e-08) identified by the published gwas; (2) four brain expression gwas datasets using expression quantitative trait loci from the cerebellum and temporal cortex; (3) large-scale ad gwas from the alzheimer disease genetics consortium (adgc); (4) a protein-protein interaction network. |
2016-08-30 |
2023-08-13 |
Not clear |
| Susan A Austin, Anantha Vijay R Santhanam, Livius V d'Uscio, Zvonimir S Katusi. Regional Heterogeneity of Cerebral Microvessels and Brain Susceptibility to Oxidative Stress. PloS one. vol 10. issue 12. 2016-06-20. PMID:26629821. |
the hippocampus is one of the earliest and most affected regions in alzheimer's disease (ad), followed by the cortex while the cerebellum is largely spared. |
2016-06-20 |
2023-08-13 |
mouse |
| Ake T Lu, Eilis Hannon, Morgan E Levine, Ke Hao, Eileen M Crimmins, Katie Lunnon, Alexey Kozlenkov, Jonathan Mill, Stella Dracheva, Steve Horvat. Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nature communications. vol 7. 2016-06-17. PMID:26830004. |
gene sets found by our gwas analysis of cerebellar age acceleration exhibit significant overlap with those of alzheimer's disease (p=4.4 × 10(-15)), age-related macular degeneration (p=6.4 × 10(-6)), and parkinson's disease (p=2.6 × 10(-4)). |
2016-06-17 |
2023-08-13 |
Not clear |
| Matthias Granold, Bernd Moosmann, Irina Staib-Lasarzik, Thomas Arendt, Adriana Del Rey, Kristin Engelhard, Christian Behl, Parvana Hajiev. High membrane protein oxidation in the human cerebral cortex. Redox biology. vol 4. 2016-06-09. PMID:25600696. |
here, we have analyzed global protein oxidation in terms of carbonylation of membrane proteins and cytoplasmic proteins in three different mammalian species: aged human cortex and cerebellum from patients with or without alzheimer's disease, mouse cortex and cerebellum from young and old animals, and adult rat hippocampus and cortex subjected or not subjected to cerebral ischemia. |
2016-06-09 |
2023-08-13 |
mouse |
| Roberto E Sic. Could astrocytes be the primary target of an offending agent causing the primary degenerative diseases of the human central nervous system? A hypothesis. Medical hypotheses. vol 84. issue 5. 2015-12-15. PMID:25697116. |
within the spectrum of these illnesses there are disorders like amyotrophic lateral sclerosis, fronto-temporal dementia, alzheimer's dementia, parkinson's disease, huntington's dementia and cerebellar ataxias affecting exclusively the human species. |
2015-12-15 |
2023-08-13 |
human |
| Mathilde Renaud, Julien Perriard, Sarah Coudray, Mathieu Sévin-Allouet, Christophe Marcel, Wassilios G Meissner, Jean-Baptiste Chanson, Nicolas Collongues, Nathalie Philippi, Odile Gebus, Véronique Quenardelle, Anna Castrioto, Paul Krack, Karine N'Guyen, François Lefebvre, Andoni Echaniz-Laguna, Jean-Philippe Azulay, Nicolas Meyer, Pierre Labauge, Christine Tranchant, Mathieu Anhei. Relevance of corpus callosum splenium versus middle cerebellar peduncle hyperintensity for FXTAS diagnosis in clinical practice. Journal of neurology. vol 262. issue 2. 2015-12-02. PMID:25451852. |
clinical and radiological study of 22 fmr1 premutation carriers with neurological signs that may be encountered in fxtas compared to series of patients with essential tremor, multiple system atrophy of cerebellar type, parkinson's disease, alzheimer's disease and stroke. |
2015-12-02 |
2023-08-13 |
Not clear |
| B Ansoleaga, P Garcia-Esparcia, F Llorens, J Moreno, E Aso, I Ferre. Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model. Neuroscience. vol 248. 2015-11-03. PMID:23817016. |
dysregulation of selected ors and tasrs has been found in the entorhinal cortex and frontal cortex in alzheimer's disease (ad) in a gradient compatible with braak and braak staging; frontal cortex in terminal stages of progressive supranuclear palsy; and frontal cortex and cerebellum in creutzfeldt-jakob disease subtypes methionine/methionine at codón 129 of prnp (mm1) and valine/valine at codón 129 of prnp (vv2). |
2015-11-03 |
2023-08-12 |
mouse |
| Paolo Bosco, Rosario Spada, Salvatore Caniglia, Maria Grazia Salluzzo, Michele Salem. Cerebellar degeneration-related autoantigen 1 (CDR1) gene expression in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 10. 2015-10-16. PMID:24777548. |
cerebellar degeneration-related autoantigen 1 (cdr1) gene expression in alzheimer's disease. |
2015-10-16 |
2023-08-13 |
Not clear |
| Timothy J Shakespeare, Diego Kaski, Keir X X Yong, Ross W Paterson, Catherine F Slattery, Natalie S Ryan, Jonathan M Schott, Sebastian J Crutc. Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy. Brain : a journal of neurology. vol 138. issue Pt 7. 2015-09-07. PMID:25895507. |
on fixation stability tasks, patients with typical alzheimer's disease showed more square wave jerks whose frequency was associated with lower cerebellar grey matter volume, while patients with posterior cortical atrophy showed large saccadic intrusions whose frequency correlated significantly with generalized reductions in cortical thickness. |
2015-09-07 |
2023-08-13 |
human |
| María-Isabel Alvarez, Luís Rivas, César Lacruz, Adolfo Toledan. Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: a histological and immunohistochemical comparison. Glia. vol 63. issue 2. 2015-08-19. PMID:25220544. |
objectives and experimental design cerebella of young adults, elderly adults, and patients with alzheimer's disease (ad) (with and without cerebellar amyloid deposits) were studied by golgi staining and glial fibrillary acid protein (gfap) immunocytochemical methods. |
2015-08-19 |
2023-08-13 |
Not clear |
| Chul Hyoung Lyoo, Masamichi Ikawa, Jeih-San Liow, Sami S Zoghbi, Cheryl L Morse, Victor W Pike, Masahiro Fujita, Robert B Innis, William Charles Kreis. Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 5. 2015-07-24. PMID:25766898. |
cerebellum can serve as a pseudo-reference region in alzheimer disease to detect neuroinflammation measured with pet radioligand binding to translocator protein. |
2015-07-24 |
2023-08-13 |
Not clear |
| Mark L Cohen, Chae Kim, Tracy Haldiman, Mohamed ElHag, Prachi Mehndiratta, Termsarasab Pichet, Frances Lissemore, Michelle Shea, Yvonne Cohen, Wei Chen, Janis Blevins, Brian S Appleby, Krystyna Surewicz, Witold K Surewicz, Martha Sajatovic, Curtis Tatsuoka, Shulin Zhang, Ping Mayo, Mariusz Butkiewicz, Jonathan L Haines, Alan J Lerner, Jiri G Safa. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25688081. |
using novel biophysical methods, we analysed levels, particle size, and conformational characteristics of amyloid-β in the posterior cingulate cortex, hippocampus and cerebellum of 48 cases of alzheimer's disease with distinctly different disease durations, and correlated the data with apoe gene polymorphism. |
2015-06-16 |
2023-08-13 |
Not clear |
| G Sh Burbaeva, I S Boksha, E B Tereshkina, O K Savushkina, T A Prokhorova, E A Vorobyev. Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase. Cerebellum (London, England). vol 13. issue 5. 2015-05-20. PMID:24950944. |
glutamate and gaba-metabolizing enzymes in post-mortem cerebellum in alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase. |
2015-05-20 |
2023-08-13 |
Not clear |
| G Sh Burbaeva, I S Boksha, E B Tereshkina, O K Savushkina, T A Prokhorova, E A Vorobyev. Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: phosphate-activated glutaminase and glutamic acid decarboxylase. Cerebellum (London, England). vol 13. issue 5. 2015-05-20. PMID:24950944. |
enzymes of glutamate and gaba metabolism in postmortem cerebellum from patients with alzheimer's disease (ad) have not been comprehensively studied. |
2015-05-20 |
2023-08-13 |
Not clear |
| Yanyao Deng, Deren Hou, Mi Tian, Wei Li, Xialu Fen. [β-amyloid peptide deposition and expression of related miRNAs in the cerebellum of a mouse model of Alzheimer's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 34. issue 3. 2015-01-05. PMID:24670442. |
[β-amyloid peptide deposition and expression of related mirnas in the cerebellum of a mouse model of alzheimer's disease]. |
2015-01-05 |
2023-08-12 |
mouse |