| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G F Koo. Neural mechanisms of drug reinforcement. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1632582. |
these effects are thought to reflect a change in the activity of reward elements in the medial forebrain bundle and may be responsible for the negative reinforcing state associated with the anhedonia of cocaine withdrawal. |
1992-08-17 |
2023-08-11 |
rat |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
chronic cocaine produces increases in brain reward thresholds that may reflect the "dysphoria" and anhedonia associated with cocaine dependence and suggests a dysregulation of brain reward systems possibly involving dopamine. |
1992-06-22 |
2023-08-11 |
rat |
| E O Hammond, M L Torok, A Ettenber. Different patterns of behavior produced by haloperidol, pentobarbital, and dantrolene in tests of unconditioned locomotion and operant responding. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1876659. |
rather, the profile of this deterioration is consistent with the anhedonia hypothesis of neuroleptic action and supports the view that dopamine neurons are involved in the biological basis of food reward. |
1991-09-26 |
2023-08-11 |
rat |
| K E Asin, D Wirtshafte. Evidence for dopamine involvement in reinforcement obtained using a latent extinction paradigm. Pharmacology, biochemistry, and behavior. vol 36. issue 2. 1990-07-20. PMID:2356217. |
these results suggest that placing the haloperidol treated rats into the baited goalbox resulted in a reduced expectation of reward and are compatible with the "anhedonia" theory of neuroleptic action. |
1990-07-20 |
2023-08-11 |
human |
| E Acquas, E Carboni, P Leone, G Di Chiar. SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade? Psychopharmacology. vol 99. issue 2. 1989-11-15. PMID:2572027. |
sch 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade? |
1989-11-15 |
2023-08-11 |
rat |
| F H Gawi. Chronic neuropharmacology of cocaine: progress in pharmacotherapy. The Journal of clinical psychiatry. vol 49 Suppl. 1988-03-15. PMID:3276669. |
recent clinical research suggests that cocaine abstinence symptoms include anhedonia, which is consistent with the decreased reward in preclinical studies. |
1988-03-15 |
2023-08-11 |
Not clear |
| A Pierson, R Ragot, A Ripoche, N Lesevr. Electrophysiological changes elicited by auditory stimuli given a positive or negative value: a study comparing anhedonic with hedonic subjects. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. vol 5. issue 2. 1987-09-11. PMID:3610727. |
eighteen subjects were divided into two groups according to their scores at two self-rating questionnaires, the chapman's physical anhedonia scale (pas) and the beck-weissman's dysfunctional attitude scale (das) that quantifies cognitive distortions presumed to constitute high risk for depression: 9 with high scores at both scales formed the a group (anhedonic-dysfunctional), 9 with low scores at both scales, the h group (hedonic-adapted) the electrophysiological indices were recorded during 3 situations: the first one was a classical cnv paradigm with a motor reaction time task in which one of 3 tones of different pitch represented the warning stimulus s1; during the second, conditioning phase, two of these tones were associated with either a success (and reward) or a failure (and punishment) during a memory task in order to make them acquire either a positive or a negative affective value; the third situation consisted in the repeating of the first cnv paradigm in order to test the effect of the positive and the negative stimuli versus the neutral one on rts and electrophysiological data. |
1987-09-11 |
2023-08-11 |
human |
| S E Gramling, S C Fowler, J P Tizzan. Some effects of pimozide on nondeprived rats' lever pressing maintained by a sucrose reward in an anhedonia paradigm. Pharmacology, biochemistry, and behavior. vol 27. issue 1. 1987-08-28. PMID:3615548. |
some effects of pimozide on nondeprived rats' lever pressing maintained by a sucrose reward in an anhedonia paradigm. |
1987-08-28 |
2023-08-11 |
rat |
| S E Gramling, S C Fowler, J P Tizzan. Some effects of pimozide on nondeprived rats' lever pressing maintained by a sucrose reward in an anhedonia paradigm. Pharmacology, biochemistry, and behavior. vol 27. issue 1. 1987-08-28. PMID:3615548. |
the present work examined the generalizability of the anhedonia phenomenon (extinction-like responding with repeated neuroleptic treatment) by examining the effects of pimozide (pim) on nondeprived rats lever pressing for a sucrose solution reward (32%) in an eight day dosing regime. |
1987-08-28 |
2023-08-11 |
rat |
| R A Wise, J Spindler, H deWit, G J Gerber. Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food. Science (New York, N.Y.). vol 201. issue 4352. 1978-08-28. PMID:566469. |
neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food. |
1978-08-28 |
2023-08-11 |
rat |