| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Russell S Dulman, James Auta, Tara Teppen, Subhash C Pande. Acute Ethanol Produces Ataxia and Induces Fmr1 Expression via Histone Modifications in the Rat Cerebellum. Alcoholism, clinical and experimental research. vol 43. issue 6. 2020-09-03. PMID:30969437. |
the cerebellum is fundamental for motor coordination and therefore crucial in ethanol (etoh)-induced ataxia. |
2020-09-03 |
2023-08-13 |
rat |
| Russell S Dulman, James Auta, Tara Teppen, Subhash C Pande. Acute Ethanol Produces Ataxia and Induces Fmr1 Expression via Histone Modifications in the Rat Cerebellum. Alcoholism, clinical and experimental research. vol 43. issue 6. 2020-09-03. PMID:30969437. |
recent studies have implicated glutamatergic targets of fmrp in hereditary cerebellar ataxias including the main cerebellar excitatory amino acid (eaa1) transporter and a subtype of metabotropic glutamate receptor (grm5). |
2020-09-03 |
2023-08-13 |
rat |
| A Artero Castro, C Machuca, F J Rodriguez Jimenez, P Jendelova, S Erce. Short Review: Investigating ARSACS: models for understanding cerebellar degeneration. Neuropathology and applied neurobiology. vol 45. issue 6. 2020-08-31. PMID:30636067. |
autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs) is an early-onset neurodegenerative disease that includes progressive cerebellar dysfunction. |
2020-08-31 |
2023-08-13 |
human |
| Basma Yacoubi, Agostina Casamento-Moran, Roxana G Burciu, S H Subramony, David E Vaillancourt, Evangelos A Christo. Temporal Invariance in SCA6 Is Related to Smaller Cerebellar Lobule VI and Greater Disease Severity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 8. 2020-08-17. PMID:31941666. |
we quantified the endpoint control of these contractions, gray matter (gm) integrity of the cerebellum, and disease severity using the international cooperative ataxia rating scale (icars). |
2020-08-17 |
2023-08-13 |
human |
| Magdalena Krygier, Mariusz Kwarciany, Krystyna Wasilewska, Victor Murcia Pienkowski, Natalia Krawczyńska, Daniel Zielonka, Joanna Kosińska, Piotr Stawinski, Monika Rudzińska-Bar, Magdalena Boczarska-Jedynak, Bartosz Karaszewski, Janusz Limon, Jarosław Sławek, Rafał Płoski, Małgorzata Rydzanic. A study in a Polish ataxia cohort indicates genetic heterogeneity and points to MTCL1 as a novel candidate gene. Clinical genetics. vol 95. issue 3. 2020-08-03. PMID:30548255. |
in addition, our study confirms the high diagnostic yield of ngs in early-onset cerebellar ataxias, with at least 50% detection rate in our ataxia cohort. |
2020-08-03 |
2023-08-13 |
mouse |
| Vanessa Hull, Yan Wang, Travis Burns, Sheng Zhang, Sarah Sternbach, Jennifer McDonough, Fuzheng Guo, David Pleasur. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Annals of neurology. vol 87. issue 3. 2020-08-03. PMID:31925837. |
we now demonstrate that inhibiting naa synthesis by intracisternal administration of a locked nucleic acid antisense oligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and diminishes cerebellar and thalamic vacuolation and purkinje cell dendritic atrophy. |
2020-08-03 |
2023-08-13 |
mouse |
| Mallory Kerner-Rossi, Maria Gulinello, Steven Walkley, Kostantin Dobreni. Pathobiology of Christianson syndrome: Linking disrupted endosomal-lysosomal function with intellectual disability and sensory impairments. Neurobiology of learning and memory. vol 165. 2020-07-30. PMID:29772390. |
christianson syndrome (cs) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. |
2020-07-30 |
2023-08-13 |
mouse |
| Shaikha Daoud Al-Shokri, Sameer Ahammed Karumannil, Saeed Saleh Mohammed, Mohamed Sulaiman Sade. Post-Epstein-Barr Virus Acute Cerebellitis in an Adult. The American journal of case reports. vol 21. 2020-07-21. PMID:31905189. |
he was found to have ataxia and cerebellar signs, bradycardia magnetic resonance imaging (mri) of the brain showed acute cerebellitis, and cerebrospinal fluid (csf) studies showed lymphocytosis. |
2020-07-21 |
2023-08-13 |
Not clear |
| S R Catford, M K O'Bryan, R I McLachlan, M B Delatycki, L Rombaut. Germ cell arrest associated with aSETX mutation in ataxia oculomotor apraxia type 2. Reproductive biomedicine online. vol 38. issue 6. 2020-07-10. PMID:30642639. |
ataxia with oculomotor apraxia type 2 (aoa2) is a rare autosomal recessive neurodegenerative disorder characterized by cerebellar atrophy, peripheral neuropathy and oculomotor apraxia. |
2020-07-10 |
2023-08-13 |
mouse |
| David Díaz, Carlos Del Pilar, José Carretero, José Ramón Alonso, Eduardo Weruag. Daily bone marrow cell transplantations for the management of fast neurodegenerative processes. Journal of tissue engineering and regenerative medicine. vol 13. issue 9. 2020-07-08. PMID:31272136. |
so far, this phenomenon has only been identified in purkinje cells, whose death is the cause of different diseases like cerebellar ataxias. |
2020-07-08 |
2023-08-13 |
mouse |
| Jusik Kim, Keeeun Kim, Jung-Soon Mo, Youngsoo Le. Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation. Nucleic acids research. vol 48. issue 7. 2020-07-06. PMID:32123907. |
however, dual inactivation of polb and atm resulted in ataxia without significant neuropathological defects in the cerebellum. |
2020-07-06 |
2023-08-13 |
mouse |
| Jusik Kim, Keeeun Kim, Jung-Soon Mo, Youngsoo Le. Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation. Nucleic acids research. vol 48. issue 7. 2020-07-06. PMID:32123907. |
our data suggest that dysregulation of itpr1 in the cerebellum could be one of contributing factors to progressive ataxia observed in human genomic instability syndromes. |
2020-07-06 |
2023-08-13 |
mouse |
| Julia Saifetiarova, Manzoor A Bha. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30447021. |
altered morphological organization and electrical properties of the purkinje axons lead to detrimental changes in locomotor activity often leading to cerebellar ataxias. |
2020-07-01 |
2023-08-13 |
Not clear |
| Giovanna De Michele, Maria Lieto, Daniele Galatolo, Elena Salvatore, Sirio Cocozza, Melissa Barghigiani, Alessandra Tessa, Jacopo Baldacci, Sabina Pappatà, Alessandro Filla, Giuseppe De Michele, Filippo M Santorell. Spinocerebellar ataxia 48 presenting with ataxia associated with cognitive, psychiatric, and extrapyramidal features: A report of two Italian families. Parkinsonism & related disorders. vol 65. 2020-06-26. PMID:31126790. |
spinocerebellar ataxia 48 has recently been described as an adult onset ataxia associated with a cerebellar cognitive affective syndrome, caused by a heterozygous mutation in the stub1 gene. |
2020-06-26 |
2023-08-13 |
Not clear |
| Ilse Eidhof, Bart P van de Warrenburg, Annette Schenc. Integrative network and brain expression analysis reveals mechanistic modules in ataxia. Journal of medical genetics. vol 56. issue 5. 2020-06-03. PMID:30591515. |
genetic forms of ataxia are a heterogenous group of degenerative diseases of the cerebellum. |
2020-06-03 |
2023-08-13 |
Not clear |
| Emiliano De Schutter, Zachariah O Adham, Jorge C Katta. Central positional vertigo: A clinical-imaging study. Progress in brain research. vol 249. 2020-05-07. PMID:31325993. |
most patients had positional nystagmus (downbeat and apogeotropic horizontal), cerebellar ocular motor abnormalities and truncal ataxia indicative of a central lesion. |
2020-05-07 |
2023-08-13 |
Not clear |
| Deborah Moreira Rangel, Paulo Ribeiro Nóbrega, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim, Pedro Braga-Net. A case series of hereditary cerebellar ataxias in a highly consanguineous population from Northeast Brazil. Parkinsonism & related disorders. vol 61. 2020-04-29. PMID:30389370. |
a case series of hereditary cerebellar ataxias in a highly consanguineous population from northeast brazil. |
2020-04-29 |
2023-08-13 |
Not clear |
| Deborah Moreira Rangel, Paulo Ribeiro Nóbrega, Maria Luiza Saraiva-Pereira, Laura Bannach Jardim, Pedro Braga-Net. A case series of hereditary cerebellar ataxias in a highly consanguineous population from Northeast Brazil. Parkinsonism & related disorders. vol 61. 2020-04-29. PMID:30389370. |
there are few studies reporting characteristics of patients with cerebellar ataxias in the brazilian population. |
2020-04-29 |
2023-08-13 |
Not clear |
| Hongyu Yuan, Huihua Yang, Linliu Peng, Yun Peng, Zhao Chen, Linlin Wan, Chunrong Wang, Yuting Shi, Victor Wei Zhang, Beisha Tang, Rong Qiu, Hong Jian. Profiling of mitochondrial genomes in SCA3/MJD patients from mainland China. Gene. vol 738. 2020-04-27. PMID:32087274. |
spinocerebellar ataxia type 3, also known as machado-joseph disease (sca3/mjd), is the most common type of autosomal dominant cerebellar ataxias. |
2020-04-27 |
2023-08-13 |
Not clear |
| Orlando G Barsottini, José Luiz Pedroso, Carlos Roberto Martins, Marcondes Cavalcante França, Pedro Mangabeira Alberna. Deafness and Vestibulopathy in Cerebellar Diseases: a Practical Approach. Cerebellum (London, England). vol 18. issue 6. 2020-04-10. PMID:31154624. |
cerebellar ataxias are a clinically heterogeneous group of neurological disorders. |
2020-04-10 |
2023-08-13 |
Not clear |