| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Albert Eugene Pekary, Schetema A Stevens, James D Blood, Albert Satti. Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor. Peptides. vol 31. issue 6. 2010-08-17. PMID:20338209. |
thyrotropin-releasing hormone (trh) is an endogenous antidepressant-like neuropeptide that reduces the expression of glycogen synthase kinase-3beta (gsk-3beta), an enzyme that hyperphosphorylates tau and is implicated in bipolar disorder, diabetes and alzheimer's disease. |
2010-08-17 |
2023-08-12 |
rat |
| Wayne Macfadden, Larry Alphs, J Thomas Haskins, Norris Turner, Ibrahim Turkoz, Cynthia Bossie, Mary Kujawa, Ramy Mahmou. A randomized, double-blind, placebo-controlled study of maintenance treatment with adjunctive risperidone long-acting therapy in patients with bipolar I disorder who relapse frequently. Bipolar disorders. vol 11. issue 8. 2010-01-27. PMID:19922552. |
this study assessed whether adjunctive maintenance treatment with risperidone long-acting therapy (rlat), added to treatment-as-usual (tau) medications for bipolar disorder, delays relapse in patients with bipolar disorder type i. |
2010-01-27 |
2023-08-12 |
Not clear |
| Mohammad A Khanfar, Bilal Abu Asal, Mudit Mudit, Amal Kaddoumi, Khalid A El Saye. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorganic & medicinal chemistry. vol 17. issue 16. 2009-10-27. PMID:19616957. |
the gsk-3beta inhibitory activity of pmhs entitles them to be potential leads for the treatment of cancer, alzheimer's disease, bipolar disorders, stroke, different tau pathologies, and type-2 diabetes. |
2009-10-27 |
2023-08-12 |
mouse |
| A John Rush, M Lynn Crismon, T Michael Kashner, Marcia G Toprac, Thomas J Carmody, Madhukar H Trivedi, Trisha Suppes, Alexander L Miller, Melanie M Biggs, Kathy Shores-Wilson, Bradley P Witte, Steven P Shon, William V Rago, Kenneth Z Altshule. Texas Medication Algorithm Project, phase 3 (TMAP-3): rationale and study design. The Journal of clinical psychiatry. vol 64. issue 4. 2003-07-01. PMID:12716235. |
this study compared clinical and economic outcomes of an algorithm-driven disease management program (algo) with treatment-as-usual (tau) for adults with dsm-iv schizophrenia (scz), bipolar disorder (bd), and major depressive disorder (mdd) treated in public mental health outpatient clinics in texas. |
2003-07-01 |
2023-08-12 |
Not clear |
| Henry Brodaty, Philip Mitchell, Georgina Luscombe, John J Kwok, Renee F Badenhop, Rod McKenzie, Peter R Schofiel. Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q. Human genetics. vol 110. issue 1. 2002-05-09. PMID:11810290. |
we genotyped all family members for microsatellite markers at the ibgc1 locus and polymorphisms of the apoe, vldl, alpha1-act, bche-k, app, ps1, ps2 and tau genes and tested these for linkage to ibgc, dementia and bipolar disorder. |
2002-05-09 |
2023-08-12 |
Not clear |
| M Lesort, A Greendorfer, C Stockmeier, G V Johnson, R S Jop. Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651115. |
therefore, in prefrontal cortical samples from subjects with bipolar disorder and age-matched control subjects, we examined the levels of glycogen synthase kinase 3beta and of two proteins modified by it, beta-catenin and the microtubule associated protein tau. |
2000-02-15 |
2023-08-12 |
human |
| M Lesort, A Greendorfer, C Stockmeier, G V Johnson, R S Jop. Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651115. |
thus, while there are no differences between bipolars and controls in prefrontal cortical levels of glycogen synthase kinase-3beta, beta-catenin, or tau, tau isoform levels or phosphorylation states may be modified in bipolar disorder. |
2000-02-15 |
2023-08-12 |
human |