| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy S Chisholm, Ronald Melki, Christopher A Hunte. Ligand Profiling as a Diagnostic Tool to Differentiate Patient-Derived α-Synuclein Polymorphs. ACS chemical neuroscience. 2024-05-01. PMID:38690599. |
eight fibrillar polymorphs of α-synuclein (αsyn) were investigated: five generated de novo using recombinant αsyn and three generated using protein misfolding cyclic amplification (pmca) of recombinant αsyn seeded with brain homogenates from deceased patients diagnosed with parkinson's disease (pd), multiple system atrophy (msa), and dementia with lewy bodies (dlb). |
2024-05-01 |
2024-05-03 |
Not clear |
| Coralie Cressot, Agathe Vrillon, Matthieu Lilamand, Hélène Francisque, Aurélie Méauzoone, Claire Hourregue, Julien Dumurgier, Emeline Marlinge, Claire Paquet, Emmanuel Cogna. Psychosis in Neurodegenerative Dementias: A Systematic Comparative Review. Journal of Alzheimer's disease : JAD. 2024-04-26. PMID:38669539. |
psychosis, characterized by delusions and/or hallucinations, is frequently observed during the progression of alzheimer's disease (ad) and other neurodegenerative dementias (nd) (i.e., dementia with lewy bodies (dlb), and frontotemporal dementia (ftd)) and cause diagnostic and management difficulties. |
2024-04-26 |
2024-04-29 |
Not clear |
| Sungwoo Kang, Seun Jeon, Young-Gun Lee, Byoung Seok Y. Alteration of medial temporal lobe metabolism related to Alzheimer's disease and dementia with lewy bodies. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-23. PMID:38654300. |
association of medial temporal lobe (mtl) metabolism with alzheimer's disease (ad) and dementia with lewy bodies (dlb) has not been evaluated considering their mixed disease (md). |
2024-04-23 |
2024-04-26 |
Not clear |
| Per Borghammer, Niels Okkels, Daniel Weintrau. Parkinson's Disease and Dementia with Lewy Bodies: One and the Same. Journal of Parkinson's disease. 2024-04-19. PMID:38640172. |
the question whether parkinson's disease dementia (pdd) and dementia with lewy bodies (dlb) are expressions of the same underlying disease has been vigorously debated for decades. |
2024-04-19 |
2024-04-22 |
Not clear |
| Alice Tisserand, Frédéric Blanc, Mary Mondino, Candice Muller, Hélène Durand, Catherine Demuynck, Paulo Loureiro de Sousa, Alix Ravier, Léa Sanna, Anne Botzung, Nathalie Philipp. Who am I with my Lewy bodies? The insula as a core region of the self-concept networks. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-19. PMID:38641653. |
dementia with lewy bodies (dlb) is characterized by insular atrophy, which occurs at the early stage of the disease. |
2024-04-19 |
2024-04-22 |
Not clear |
| Melissa J Armstrong, Yunfeng Dai, Kaitlin Sovich, Brian LaBarre, Henry L Paulson, Susan M Maixner, Julie A Fields, Angela M Lunde, Leah K Forsberg, Bradley F Boeve, Carol A Manning, James E Galvin, Angela S Taylor, Zhigang L. Caregiver Experiences and Burden in Moderate-Advanced Dementia With Lewy Bodies. Neurology. Clinical practice. vol 14. issue 3. 2024-04-15. PMID:38617555. |
dementia with lewy bodies (dlb) is a common degenerative dementia, but research on caregiver experiences in late stages is lacking. |
2024-04-15 |
2024-04-17 |
Not clear |
| Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A Rissman, Eliezer Maslia. Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease. Journal of neuroinflammation. vol 21. issue 1. 2024-04-15. PMID:38622654. |
the neuroinflammatory process in synucleinopathies of the aging population such as parkinson's disease (pd) and dementia with lewy bodies (dlb) involves microglial activation as well as infiltration of the cns by t cells and natural killer t cells (nkts). |
2024-04-15 |
2024-04-18 |
mouse |
| Annegret Habich, Javier Oltra, Christopher G Schwarz, Scott A Przybelski, Ketil Oppedal, Anna Inguanzo, Frédéric Blanc, Afina W Lemstra, Jakub Hort, Eric Westman, Barbara Segura, Carme Junque, Val J Lowe, Bradley F Boeve, Dag Aarsland, Thomas Dierks, Kejal Kantarci, Daniel Ferreir. Grey matter networks in women and men with dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-13. PMID:38615089. |
sex differences permeate many aspects of dementia with lewy bodies (dlb), yet sex differences in patterns of neurodegeneration in dlb remain largely unexplored. |
2024-04-13 |
2024-04-16 |
Not clear |
| Alberto J Rico, Almudena Corcho, Julia Chocarro, Goiaz Ariznabarreta, Elvira Roda, Adriana Honrubia, Patricia Arnaiz, José L Lancieg. Development and characterization of a non-human primate model of disseminated synucleinopathy. Frontiers in neuroanatomy. vol 18. 2024-04-11. PMID:38601798. |
the presence of a widespread cortical synucleinopathy is the main neuropathological hallmark underlying clinical entities such as parkinson's disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2024-04-11 |
2024-04-13 |
Not clear |
| Taku Hatano, Ayami Okuzumi, Gen Matsumoto, Tsunemi Taiji, Nobutaka Hattor. α-Synuclein: A Promising Biomarker for Parkinson's Disease and Related Disorders. Journal of movement disorders. 2024-04-08. PMID:38589016. |
rapid eye movement sleep behavior disorder (rbd) patients often progress to pd, dementia with lewy bodies (dlb), or msa, collectively known as α-synucleinopathies. |
2024-04-08 |
2024-04-11 |
Not clear |
| Tim E Moors, Martino L Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Timmermans-Huisman, Angela M T Ingrassia, John J P Brevé, John G J M Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D J van de Ber. Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases. Acta neuropathologica. vol 147. issue 1. 2024-04-08. PMID:38581586. |
transcription factor eb (tfeb) is a master regulator of genes involved in the maintenance of autophagic and lysosomal homeostasis, processes which have been implicated in the pathogenesis of gba-related and sporadic parkinson's disease (pd), and dementia with lewy bodies (dlb). |
2024-04-08 |
2024-04-10 |
human |
| Elijah Mak, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Christopher G Schwarz, Matthew L Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R Jack, Hoon Ki Min, Manoj K Jain, Toji Miyagawa, Leah K Forsberg, Julie A Fields, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, Hugo Botha, Erik K St Louis, David S Knopman, Vijay K Ramanan, Dennis W Dickson, Neill R Graff-Radford, Tanis J Ferman, Ronald C Petersen, Val J Lowe, Bradley F Boeve, John T O'Brien, Kejal Kantarc. Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies. NPJ Parkinson's disease. vol 10. issue 1. 2024-04-03. PMID:38570511. |
dementia with lewy bodies (dlb) is a neurodegenerative condition often co-occurring with alzheimer's disease (ad) pathology. |
2024-04-03 |
2024-04-06 |
Not clear |
| Daiki Ishimaru, Hideki Kanemoto, Maki Hotta, Yuma Nagata, Fuyuki Koizumi, Yuto Satake, Daiki Taomoto, Manabu Iked. Case report: Environmental adjustment for visual hallucinations in dementia with Lewy bodies based on photo assessment of the living environment. Frontiers in psychiatry. vol 15. 2024-04-01. PMID:38559397. |
visual hallucinations (vh) are associated with visual prediction error in patients with dementia with lewy bodies (dlb). |
2024-04-01 |
2024-04-04 |
Not clear |
| R Bhome, S Verdi, S A Martin, N Hannaway, I Dobreva, N P Oxtoby, G Castro Leal, S Rutherford, A F Marquand, R S Weil, J H Col. A neuroimaging measure to capture heterogeneous patterns of atrophy in Parkinson's disease and dementia with Lewy bodies. NeuroImage. Clinical. vol 42. 2024-03-30. PMID:38554485. |
parkinson's disease (pd) and dementia with lewy bodies (dlb) show heterogeneous brain atrophy patterns which group-average analyses fail to capture. |
2024-03-30 |
2024-04-02 |
human |
| Mattias Haglund, Isak Heyman, Keivan Javanshir. Progressive QTc prolongation and reduced heart rate variability in dementia with Lewy bodies compared to Alzheimer's disease. Parkinsonism & related disorders. vol 122. 2024-03-28. PMID:38547558. |
autonomic dysfunction (aud) is a significant clinical challenge in patients with dementia with lewy bodies (dlb). |
2024-03-28 |
2024-03-31 |
Not clear |
| Rita Ferreira, António J Bastos-Leit. Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review. Neuroradiology. 2024-03-27. PMID:38536448. |
the studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (mci), alzheimer's disease (ad), frontotemporal lobar degeneration (ftld), dementia with lewy bodies (dlb) and vascular cognitive impairment (vci); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder. |
2024-03-27 |
2024-03-30 |
human |
| Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Mila. Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia. Brain : a journal of neurology. 2024-03-25. PMID:38527854. |
we tested to what extent effects of known dementia risk loci can be observed in csf levels of 665 proteins (proximity extension-based (pea) immunoassays) in a deeply-phenotyped mixed-memory clinic cohort (n=502, mean age (sd) = 64.1 [8.7] years, 181 female [35.4%]), including patients with alzheimer's disease (ad, n=213), dementia with lewy bodies (dlb, n=50) and frontotemporal dementia (ftd, n=93), and controls (n=146). |
2024-03-25 |
2024-03-28 |
Not clear |
| Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Mila. Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia. Brain : a journal of neurology. 2024-03-25. PMID:38527854. |
we further identified pqtls in stratified analyses for ad and dlb, hinting at disease-specific pqtls in dementia. |
2024-03-25 |
2024-03-28 |
Not clear |
| Christopher H Gibbons, Todd Levine, Charles Adler, Bailey Bellaire, Ningshan Wang, Jade Stohl, Pinky Agarwal, Georgina M Aldridge, Alexandru Barboi, Virgilio G H Evidente, Douglas Galasko, Michael D Geschwind, Alejandra Gonzalez-Duarte, Ramon Gil, Mark Gudesblatt, Stuart H Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J Liu, Nikolaus R McFarland, Mitchell Miglis, Adam Reynolds, Gregory A Sahagian, Marie-Helene Saint-Hillaire, Julie B Schwartzbard, Wolfgang Singer, Michael J Soileau, Steven Vernino, Oleg Yerstein, Roy Freema. Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies. JAMA. 2024-03-20. PMID:38506839. |
finding a reliable diagnostic biomarker for the disorders collectively known as synucleinopathies (parkinson disease [pd], dementia with lewy bodies [dlb], multiple system atrophy [msa], and pure autonomic failure [paf]) is an urgent unmet need. |
2024-03-20 |
2024-03-23 |
Not clear |
| Margalida Puigròs, Anna Calderon, Daniel Martín-Ruiz, Mònica Serradell, Manel Fernández, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaria, Carles Gaig, Anna Colell, Eduard Tolosa, Alex Iranzo, Ramon Trulla. Mitochondrial DNA deletions in the cerebrospinal fluid of patients with idiopathic REM sleep behaviour disorder. EBioMedicine. vol 102. 2024-03-19. PMID:38502973. |
idiopathic rapid eye movement (rem) sleep behaviour disorder (irbd) represents the prodromal stage of lewy body disorders (parkinson's disease (pd) and dementia with lewy bodies (dlb)) which are linked to variations in circulating cell-free mitochondrial dna (cf-mtdna). |
2024-03-19 |
2024-03-23 |
Not clear |