| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C K Burton, I K Ho, B Hoskin. Effect of cyclo(Leu-Gly) on cyclic GMP-phosphodiesterase activity changes associated with development of tolerance to morphine-induced antinociception, catalepsy, respiratory depression and mydriasis. The Journal of pharmacology and experimental therapeutics. vol 258. issue 3. 1991-10-17. PMID:1653844. |
previous studies in our laboratory indicated that the development of complete tolerance to certain morphine-induced behaviors (antinociception, catalepsy and respiratory depression) is associated with changes in the activity of some form(s) of phosphodiesterase with cyclic gmp as substrate (cgmp-pde) activity in the brain areas that mediate these behaviors (periaqueductal gray, striatum and medulla). |
1991-10-17 |
2023-08-11 |
rat |
| M M Heinricher, K Drasne. Lumbar intrathecal morphine alters activity of putative nociceptive modulatory neurons in rostral ventromedial medulla. Brain research. vol 549. issue 2. 1991-10-04. PMID:1884228. |
we have previously shown that administration of morphine either systemically or by microinjection into the periaqueductal gray (pag) produces an increase in the activity of all off-cells and a depression of the activity of all on-cells concomitant with inhibition of the tail flick reflex. |
1991-10-04 |
2023-08-11 |
rat |
| V A Iakhnitsa, E V Gur. [Effect of partial transection of the medulla oblongata on inhibition of the mouth-opening reflex of the cat induced by stimulation of the mesencephalic central gray]. Neirofiziologiia = Neurophysiology. vol 19. issue 3. 1987-09-02. PMID:3614456. |
there were no changes in the ljr depression when the central grey matter was stimulated by short trains of stimuli after section. |
1987-09-02 |
2023-08-11 |
cat |
| V A Iakhnitsa, E V Gur. [Effect of partial transection of the medulla oblongata on inhibition of the mouth-opening reflex of the cat induced by stimulation of the mesencephalic central gray]. Neirofiziologiia = Neurophysiology. vol 19. issue 3. 1987-09-02. PMID:3614456. |
the ljr suppression evoked by the prolonged central grey matter stimulation reached 25-50% in intact animals, while after the section the depression increased and reached 75% (three animals) or was reduced and reached 15-20% (four animals). |
1987-09-02 |
2023-08-11 |
cat |
| V A Iakhnitsa, E V Gur. [Effect of partial transection of the medulla oblongata on inhibition of the mouth-opening reflex of the cat induced by stimulation of the mesencephalic central gray]. Neirofiziologiia = Neurophysiology. vol 19. issue 3. 1987-09-02. PMID:3614456. |
stimulation of the central grey matter by a short train of stimuli evoked depression of hjr which reached 100% in intact animals, while after the section--only 40-60%. |
1987-09-02 |
2023-08-11 |
cat |
| R W Clark. The effects of decerebration and destruction of nucleus raphe magnus, periaqueductal grey matter and brainstem lateral reticular formation on the depression due to surgical trauma of the jaw-opening reflex evoked by tooth-pulp stimulation in the cat. Brain research. vol 332. issue 2. 1985-06-25. PMID:3995269. |
the effects of decerebration and destruction of nucleus raphe magnus, periaqueductal grey matter and brainstem lateral reticular formation on the depression due to surgical trauma of the jaw-opening reflex evoked by tooth-pulp stimulation in the cat. |
1985-06-25 |
2023-08-11 |
cat |
| J M Lakoski, G F Gebhar. Depression of neuronal activity in the hypothalamic ventromedial nucleus of the rat following microinjection of morphine in the amygdala or the periaqueductal gray. Neuroscience. vol 12. issue 1. 1984-08-24. PMID:6462448. |
when microinjected bilaterally in the cortical amygdala or periaqueductal gray (5 micrograms/site), morphine produced the same maximal depression of unit activity in the ventromedial nucleus as when administered intravenously. |
1984-08-24 |
2023-08-12 |
rat |
| J M Lakoski, G F Gebhar. Depression of neuronal activity in the hypothalamic ventromedial nucleus of the rat following microinjection of morphine in the amygdala or the periaqueductal gray. Neuroscience. vol 12. issue 1. 1984-08-24. PMID:6462448. |
depression of neuronal activity in the hypothalamic ventromedial nucleus of the rat following microinjection of morphine in the amygdala or the periaqueductal gray. |
1984-08-24 |
2023-08-12 |
rat |
| K B Franklin, A Robertso. Effects and interactions of naloxone and amphetamine on self-stimulation of the prefrontal cortex and dorsal tegmentum. Pharmacology, biochemistry, and behavior. vol 16. issue 3. 1982-07-19. PMID:7079280. |
naloxone (0.1 to 10 mg/kg) caused a dose-dependent depression of self-stimulation of the medial prefrontal cortex (pfc) lateral hypothalamus (lh) and a region in the dorsal tegmentum lateral to the central gray (dt). |
1982-07-19 |
2023-08-12 |
Not clear |
| Yutaka Sakai, Yoshiaki Nishijima, Naoji Mikuni, Nobuyoshi Iwat. Inhibitory mechanisms of the hyper-irritability caused by picrotoxin in the rat. Pain. vol 11. issue 1. 1982-01-28. PMID:7301400. |
similar depression of the hyper-irritability was caused by electrical stimulation of the central gray. |
1982-01-28 |
2023-08-12 |
rat |
| J M Lakoski, G F Gebhar. Attenuation of morphine's depression of serum luteinizing hormone by lesions in the amygdala. Neuroendocrinology. vol 33. issue 2. 1981-10-25. PMID:7022252. |
discrete bilateral electrolytic lesions of amygdaloid nuclei or the periaqueductal central gray (pag) were employed to investigate the role of these extrahypothalamic regions in the morphine-induced depression of serum levels of lh in the male rat. |
1981-10-25 |
2023-08-12 |
human |